2020
Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage
Gul Z, Demircan C, Bagdas D, Buyukuysal RL. Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage. International Journal Of Neuroscience 2020, 130: 1183-1191. PMID: 32064981, DOI: 10.1080/00207454.2020.1730830.Peer-Reviewed Original ResearchConceptsOxygen-glucose deprivationCortical slicesRat cortical slicesMale Sprague-DawleyAged male ratsOGD mediumS100B levelsLactate dehydrogenase leakageCerebral cortexControl conditionYoung slicesMale ratsSprague-DawleyAged animalsBrain regionsBrain tissueReoxygenationMore increaseStaining intensityDehydrogenase leakagePossible involvementMinutes incubationRatsPresent studySimilar decline
2016
Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol
Gul Z, Demircan C, Bagdas D, Buyukuysal R. Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol. Neurochemical Research 2016, 41: 2075-2085. PMID: 27161374, DOI: 10.1007/s11064-016-1919-8.Peer-Reviewed Original ResearchConceptsOxidative stress parametersCortical slicesRat brain slicesRat cortical slicesStress parametersChlorogenic acidChloride stainingProtective effectBrain slicesOxidative stressQuinic acidResveratrolNatural phenolic compoundsMain metaboliteMalondialdehydeCaffeic acidROS levelsIncubation mediumPhenolic compoundsAlterationsIC50 valuesPresent studyStainingΜM H2O2Oxygen species
2005
Xanthine oxidase, nitric oxide synthase and phospholipase A2 produce reactive oxygen species via mitochondria
Sanganahalli B, Joshi P, Joshi N. Xanthine oxidase, nitric oxide synthase and phospholipase A2 produce reactive oxygen species via mitochondria. Brain Research 2005, 1037: 200-203. PMID: 15777770, DOI: 10.1016/j.brainres.2005.01.013.Peer-Reviewed Original ResearchConceptsMitochondrial depolarizationReactive oxygen speciesReactive oxygen species formationROS formationGlutamate-induced oxidative stressOxygen speciesDepolarized mitochondriaCytoplasmic enzymeFormation of reactive oxygen speciesNitric oxide synthaseRat cortical slicesL-NAMEMitochondriaPhospholipase A(2Presence of allopurinolSpeciesEnzymeAssociated with excitotoxicityCortical slicesPLA(2PhospholipasePhospholipase A2Xanthine oxidaseSynthaseOxidative stress
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