2020
Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export
Nagatake T, Zhao Y, Ito T, Itoh M, Kometani K, Furuse M, Saika A, Node E, Kunisawa J, Minato N, Hamazaki Y. Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export. International Immunology 2020, 33: 171-182. PMID: 33038259, PMCID: PMC7936066, DOI: 10.1093/intimm/dxaa069.Peer-Reviewed Original ResearchConceptsCortico-medullary junctionBlood-thymus barrierEndothelial cellsClaudin-5Biotin tracerCortical vasculatureBlood-borne moleculesCentral tolerance inductionT cell exportThymic endothelial cellsEC cell linesSphingosine-1-PhosphateT cell developmentDendritic cellsThymic cortexTolerance inductionTrans-endothelial resistanceThymocyte egressVascular permeabilityThymic microenvironmentMature thymocytesMedullaBlood circulationSelective expressionMedullary parenchyma
1999
Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus
Bowlus C, Ahn J, Chu T, Gruen J. Cloning of a Novel MHC-Encoded Serine Peptidase Highly Expressed by Cortical Epithelial Cells of the Thymus. Cellular Immunology 1999, 196: 80-86. PMID: 10527559, DOI: 10.1006/cimm.1999.1543.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAntigens, Differentiation, B-LymphocyteBase SequenceCarboxypeptidasesConsensus SequenceCosmidsEpithelial CellsFluorescent Antibody Technique, IndirectGenesHistocompatibility Antigens Class IIHumansIn Situ HybridizationLysosomesMajor Histocompatibility ComplexMiceMice, Inbred C57BLMolecular Sequence DataSequence AlignmentSequence Homology, Amino AcidSerine EndopeptidasesThymus GlandConceptsCortical thymic epithelial cellsAntigen-presenting cellsThymic epithelial cellsEpithelial cellsMHC class II presentationClass II antigen processingMHC class II antigen processingClass II presentationCortical epithelial cellsMajor histocompatibility complex regionThymic capsuleThymic cortexAntigen presentationT cellsSerine proteasesStrong stainingNovel MHCAntigen processingInvariant chainCathepsin SProteolytic milieuThymusPresentationSitu hybridizationStaining
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