2023
Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor
McNamara B, Harold J, Manavella D, Bellone S, Mutlu L, Hartwich T, Zipponi M, Yang-Hartwich Y, Demirkiran C, Verzosa M, Yang K, Choi J, Dong W, Buza N, Hui P, Altwerger G, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Burton E, Inagaki H, Albers A, Zhang C, Bollag G, Schlessinger J, Santin A. Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor. Gynecologic Oncology 2023, 172: 65-71. PMID: 36958197, PMCID: PMC10192120, DOI: 10.1016/j.ygyno.2023.03.009.Peer-Reviewed Original ResearchConceptsUterine leiomyosarcomaPDX modelsGain of functionMedian overall survivalPhase I trialOral gavage dailyVivo activityTumor growth inhibitionTumor volume differencesTumor cell proliferationOverall survivalTolerable toxicityI trialOral treatmentTreatment cohortsGavage dailyAggressive tumorsSCID miceULMS patientsPK studiesTumor samplesWestern blotCell proliferationControl vehicleLeiomyosarcoma
2019
Magnetic Resonance Imaging to Rule out Leiomyosarcoma in Patients Undergoing Surgery for Leiomyomas: A Real World Experience in an Unenhanced Patient Population
Lerner V, Ringel N, Meyer J, Bennett G, Boyd L. Magnetic Resonance Imaging to Rule out Leiomyosarcoma in Patients Undergoing Surgery for Leiomyomas: A Real World Experience in an Unenhanced Patient Population. Journal Of Gynecologic Surgery 2019, 35: 363-369. DOI: 10.1089/gyn.2019.0037.Peer-Reviewed Original ResearchMagnetic resonance imagingAbnormal magnetic resonance imagingHigh lactate dehydrogenaseLactate dehydrogenasePredictive valueNormal magnetic resonance imagingRetrospective observational cohort studyNegative magnetic resonance imagingPreoperative magnetic resonance imagingObservational cohort studyNormal lactate dehydrogenaseCase of leiomyosarcomaNegative predictive valuePositive predictive valueDiffusion-weighted imagingPostprotocol cohortCohort studyMalignant leiomyosarcomaUterine pathologyPatient populationPathology resultsBenign leiomyomaLeiomyosarcomaMRI resultsPatients
2017
Leiomyosarcoma of the infratemporal fossa with perineurial spread along the right mandibular nerve: a case report
Barbiero FJ, Huttner AJ, Judson BL, Baehring JM. Leiomyosarcoma of the infratemporal fossa with perineurial spread along the right mandibular nerve: a case report. CNS Oncology 2017, 06: 281-285. PMID: 28990793, PMCID: PMC6004886, DOI: 10.2217/cns-2017-0004.Peer-Reviewed Original ResearchConceptsMandibular nerveRight mandibular nerveRight cavernous sinusSmooth muscle differentiationNerve biopsyCase reportMass lesionNeck cancerCavernous sinusMalignant tumorsGI tractInfratemporal fossaMedical literatureLeiomyosarcomaSkin appendagesSimilar casesNerveTumorsMuscle differentiationPeculiar patternDiplopiaHeadacheBiopsyPatientsMyometrium
2014
p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma
Alomari AK, Glusac EJ, McNiff JM. p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. Journal Of Cutaneous Pathology 2014, 41: 839-845. PMID: 25263848, DOI: 10.1111/cup.12388.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaAtypical fibroxanthomaCell carcinomaNon-cutaneous squamous-cell carcinomaNuclear stainingNon-squamous tumorsGiant cell tumorCutaneous leiomyosarcomaExclusive nuclear stainingCell tumorsDiagnostic challengeCytokeratin MNF116Focal stainingMNF116Tumor cytoplasmLeiomyosarcomaDiagnostic accuracyControl casesSoft tissueSpecific markersP40StainingCarcinomaP63TumorsPerioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone.
Kaye AD, Alian AA, Vadivelu N, Chung KS. Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone. Journal Of Opioid Management 2014, 10: 69-72. PMID: 24604572, DOI: 10.5055/jom.2014.0194.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaHigh dosesHigh-dose opioidsCancer-related painPresent case reportMega dosesOpioid requirementsOpioid managementMetastatic leiomyosarcomaAgonist clonidineCase reportPotent analgesicOpioidsPatientsSuccessful managementDosesPainMethadoneMorphineHyperalgesiaClonidineAnalgesicsLeiomyosarcomaManagementAntagonist
2012
In vitro chemosensitivity assay for patients with gynecologic sarcoma.
Santin A, Varughese J, Chan J, McClure C, Lea J. In vitro chemosensitivity assay for patients with gynecologic sarcoma. Journal Of Clinical Oncology 2012, 30: e13078-e13078. DOI: 10.1200/jco.2012.30.15_suppl.e13078.Peer-Reviewed Original Research
2007
Metastatic Uterine Leiomyosarcoma Regression Using an Aromatase Inhibitor
Hardman MP, Roman JJ, Burnett AF, Santin AD. Metastatic Uterine Leiomyosarcoma Regression Using an Aromatase Inhibitor. Obstetrics And Gynecology 2007, 110: 518-520. PMID: 17666649, DOI: 10.1097/01.aog.0000267533.56546.c2.Peer-Reviewed Original ResearchConceptsUterine leiomyosarcomaAromatase inhibitorsTotal abdominal hysterectomyUterine leiomyosarcoma metastaticEstrogen receptor positivityPrimary uterine leiomyosarcomaMetastatic tumor nodulesAdjuvant platinumAnastrozole dailyLeiomyosarcoma metastaticAbdominal hysterectomyObjective responseReceptor positivityTumor depositsChemotherapeutic optionsDoxorubicin chemotherapySerial imagingTumor regressionTumor nodulesLeiomyosarcomaLungInhibitorsHysterectomyNulligravidaMetastatic
2003
Gastrointestinal Leiomyosarcoma in 14 Dogs
Cohen M, Post G, Wright J. Gastrointestinal Leiomyosarcoma in 14 Dogs. Journal Of Veterinary Internal Medicine 2003, 17: 107-110. PMID: 12564735, DOI: 10.1111/j.1939-1676.2003.tb01331.x.Peer-Reviewed Original ResearchConceptsImmediate postoperative periodIntestinal leiomyosarcomaPostoperative periodTime of surgeryCommon clinical signsClinical characteristic featuresLong-term survivalMedian survivalRetrospective reviewSurgical excisionGastrointestinal leiomyosarcomaLonger survivalClinical signsMean survivalSurvival rateLeiomyosarcomaDogsSurvivalSurgeryMonthsPolyuriaHypoglycemiaPolydipsiaAnemiaMetastasis
1996
Subclassification of Gastrointestinal Stromal Tumors Based on Evaluation by Electron Microscopy and Immunohistochemistry
Erlandson R, Klimstra D, Woodruff J. Subclassification of Gastrointestinal Stromal Tumors Based on Evaluation by Electron Microscopy and Immunohistochemistry. Ultrastructural Pathology 1996, 20: 373-393. PMID: 8837346, DOI: 10.3109/01913129609016340.Peer-Reviewed Original ResearchConceptsGastrointestinal autonomic nerve tumorsGastrointestinal stromal tumorsSmooth muscle tumorsMuscle tumorsStromal tumorsNeuron specific enolase positive cellsSmall intestineNerve tumorsSynapse-like structuresLeiomyosarcoma casesImmunophenotypic analysisCD34+HHF-35Smooth muscleTumor cellsPositive cellsImmunohistochemical studiesTumorSensitive markerUltrastructural examinationLeiomyosarcomaUltrastructural demonstrationNeurosecretory granulesCD34Immunophenotype
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