2019
Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression
Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. Journal Of Clinical Investigation 2019, 129: 3058-3071. PMID: 31112135, PMCID: PMC6668688, DOI: 10.1172/jci122936.Peer-Reviewed Original ResearchConceptsLactation-induced bone lossParathyroid hormoneBone lossBone resorptionCathepsin KMilk calcium levelsParathyroid hormone suppressionSerum parathyroid hormoneRegulation of PTHOsteoclastic bone resorptionTrabecular bone volumeOsteocyte lacunar areaHormone suppressionHigh calcium demandOsteoclast numberCortical thicknessEffect of lactationCalcium levelsNormal rangeBone volumeCalcium demandExact mechanismLacunar areaResorptionSufficient calcium
2014
Loss of Cbl–PI3K interaction in mice prevents significant bone loss following ovariectomy
Adapala NS, Holland D, Scanlon V, Barbe MF, Langdon WY, Tsygankov AY, Lorenzo JA, Sanjay A. Loss of Cbl–PI3K interaction in mice prevents significant bone loss following ovariectomy. Bone 2014, 67: 1-9. PMID: 24994594, PMCID: PMC4149851, DOI: 10.1016/j.bone.2014.06.013.Peer-Reviewed Original ResearchConceptsCbl-PI3K interactionSignificant bone lossBone lossSerum levelsBone resorptionBone remodelingPro-collagen type 1Bone resorbing activityDefective bone resorptionC-terminal telopeptideP1NP levelsSerum CTXResorbing activityL2 vertebraBone volumeOvariectomyTyrosine 737Mice resultsType 1Lumbar vertebraeMiceBone formationOsteoclast migrationBone developmentResorption
2009
Zoledronate reduces unwanted bone resorption in intercalary bone allografts
Seo SW, Cho SK, Storer SK, Lee FY. Zoledronate reduces unwanted bone resorption in intercalary bone allografts. International Orthopaedics 2009, 34: 599-603. PMID: 19343345, PMCID: PMC2903128, DOI: 10.1007/s00264-009-0748-7.Peer-Reviewed Original ResearchConceptsAllograft resorptionIntercalary allograftsBone resorptionBone allograftControl groupZoledronate solutionIntercalary bone allograftsBone formationBone mineral densitySynthetic pyrophosphate analoguesHigh-dose bisphosphonatesPharmacological modificationGraft incorporationMineral densityBone densityAllograftsIdeal doseResorptionAnimal trialsHistological analysisBisphosphonatesSegmental defectsPyrophosphate analogsExperimental groupRat femur
2007
Dietary protein increases intestinal calcium absorption and improves bone balance: An hypothesis
Kerstetter J, Gaffney E, O'Brien K, Caseria D, Insogna K. Dietary protein increases intestinal calcium absorption and improves bone balance: An hypothesis. International Congress Series 2007, 1297: 204-216. DOI: 10.1016/j.ics.2006.08.027.Peer-Reviewed Original ResearchBone mineral densityIntestinal calcium absorptionHigh-protein dietUrinary calciumBone lossCalcium absorptionProtein dietAccelerated bone lossMost cross-sectional studiesDietary proteinCross-sectional studyLow-protein dietBone turnoverBone resorptionMineral densityBone balanceCalcium studiesCalcium retentionSalutary effectsBone originPrincipal outcomeDietSignificant reductionCalciumResorption
2004
Hypercalcemia and Hypercalcemia Treatment
Kinder B. Hypercalcemia and Hypercalcemia Treatment. 2004, 517-529. DOI: 10.1016/b0-12-475570-4/00643-0.Peer-Reviewed Original ResearchGastrointestinal calcium absorptionNormal calcium regulationRenal calcium excretionUrgent clinical problemHypercalcemia treatmentCalcium excretionRole of calciumCalcium absorptionNew bone formationBone resorptionClinical problemHypercalcemiaAppropriate managementBone formationCalcium regulationHomeostatic systemPatientsExcretionResorptionHigh Protein Diets, Calcium Economy, and Bone Health
Kerstetter J, O'Brien K, Insogna K. High Protein Diets, Calcium Economy, and Bone Health. Topics In Clinical Nutrition 2004, 19: 57-70. DOI: 10.1097/00008486-200401000-00010.Peer-Reviewed Original ResearchHigh-protein dietProtein dietDecrease bone densityUrinary calcium excretionDietary proteinHigh dietary proteinCalcium excretionUrinary calciumBone healthSkeletal healthCalcium economyBone resorptionBone densityLong-term consequencesDietBoneSignificant scientific dataPhysiological mechanismsHealthHumansExcretionResorptionProtein
2001
IL-6 negatively regulates IL-11 production in vitro and in vivo.
Nakchbandi I, Mitnick M, Masiukiewicz U, Sun B, Insogna K. IL-6 negatively regulates IL-11 production in vitro and in vivo. Endocrinology 2001, 142: 3850-6. PMID: 11517162, DOI: 10.1210/endo.142.9.8368.Peer-Reviewed Original ResearchConceptsIL-11 productionIL-6IL-11Bone resorptionOsteoclast formationIL-6 levelsIL-11 levelsFive-day infusionPTH excessPrimary hyperparathyroidismSerum levelsResorptive responseParathyroid adenomectomyPretreatment of cellsHuman PTHNonimmune serumPTHEffect of pretreatmentMRNA levelsSteady-state mRNA levelsPatientsCytokinesHuman osteoblast-like cellsResorptionSaos-2 cells
1999
Student Research Award 1998: Cytokine‐mediated bone resorption is cytochrome P‐450 dependent
Young N, Chole R. Student Research Award 1998: Cytokine‐mediated bone resorption is cytochrome P‐450 dependent. Otolaryngology 1999, 121: 708-712. PMID: 10580224, DOI: 10.1053/hn.1999.v121.a101034.Peer-Reviewed Original ResearchConceptsCytokine-induced bone resorptionBone resorptionNitric oxideChronic otitis mediaCytochrome PBone lossOtitis mediaTumor necrosisInterleukin-1betaNO synthaseL-arginineBone remodelingResorptionPowerful inducerSelective inhibitorCytokinesPossible roleNOSConcomitant reductionBoneCellular eventsInhibitorsAlternative pathwayEssential cofactorMorbidityA Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo
Grey A, Mitnick M, Masiukiewicz U, Sun B, Rudikoff S, Jilka R, Manolagas S, Insogna K. A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo. Endocrinology 1999, 140: 4683-4690. PMID: 10499526, DOI: 10.1210/endo.140.10.7036.Peer-Reviewed Original ResearchConceptsParathyroid hormoneInterleukin-6Bone resorptionBiochemical markersPTH infusionEffect of PTHIL-6 productionCytokine interleukin-6Bone-resorbing cellsRelease of calciumPrimary hyperparathyroidismSerum levelsOsteoblastic cellsParacrine agentsCalcium homeostasisExperimental animalsPermissive roleChronic deficiencyResorptionImportant mediatorSystemic levelsBone formationRegulatory effectsInfusionMarkers
1996
Colony stimulating factor‐1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone‐related protein
Weir E, Lowik C, Paliwal I, Insogna K. Colony stimulating factor‐1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone‐related protein. Journal Of Bone And Mineral Research 1996, 11: 1474-1481. PMID: 8889847, DOI: 10.1002/jbmr.5650111014.Peer-Reviewed Original ResearchConceptsBone resorptionMature osteoclastsParathyroid hormoneOsteoclast precursorsFetal rat long bonesParathyroid hormone-related proteinResistant acid phosphatase-positive osteoclastsMitogenic activityFactor 1Hormone-related proteinOrgan cultureCSF-1Rat long bonesTreatment of boneSignificant increaseOrgan culture assayHistological examinationBone assayOsteoclast recruitmentOsteoclast formationRat osteoclastsColony stimulating factor 1CSF-1 productionPTHResorption
1990
Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase
Brown G, Morris C, Mitnick M, Insogna K. Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase. Journal Of Bone And Mineral Research 1990, 5: 1037-1041. PMID: 1964358, DOI: 10.1002/jbmr.5650051007.Peer-Reviewed Original ResearchConceptsSerum calciumBone resorptionHumoral hypercalcemiaCarbonic anhydrase inhibitorsNephrogenous cyclic AMP excretionCyclic AMP excretionMean serum calciumOsteoclastic bone resorptionDrug-treated animalsLeydig cell tumorMechanism of actionUrine phosphorusUrine calciumSerum phosphorusCell tumorsAcetazolamide treatmentHypercalcemiaSignificant fallFisher ratsObserved hypercalcemiaResorptionDirect inhibitionSignificant riseMalignancyRatsTHE PARATHYROID HORMONE-RELATED PROTEIN STIMULATES HUMAN OSTEOBLAST-LIKE CELLS TO SECRETE A 9,000 DALTON BONERESORBING PROTEIN
Morris CA, Mitnick ME, Weir EC, Horowitz M, Kreider BL, Insogna KL. THE PARATHYROID HORMONE-RELATED PROTEIN STIMULATES HUMAN OSTEOBLAST-LIKE CELLS TO SECRETE A 9,000 DALTON BONERESORBING PROTEIN. Endocrinology 1990, 126: 1783-1786. PMID: 2307127, DOI: 10.1210/endo-126-3-1783.Peer-Reviewed Original ResearchConceptsParathyroid hormone-related proteinBone-resorbing activityHormone-related proteinBone resorptionPTH/Bone-resorbing cytokinesIL-1GM-CSFSingle fractionSequential reverse-phase HPLCII cellsUntreated cellsKD fractionHuman osteoblast-like cellsResorptionSize-exclusion HPLCNgeqOsteoblast-like cellsSpecific activityCellsKD proteinOsteoblastsReversed-phase HPLCCytokinesPGE2
1988
Adenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac
Weir E, Centrella M, Matus R, Brooks M, Wu T, Insogna K. Adenylate cyclase-stimulating, bone-resorbing and B TGF-like activities in canine apocrine cell adenocarcinoma of the anal sac. Calcified Tissue International 1988, 43: 359-365. PMID: 3146425, DOI: 10.1007/bf02553279.Peer-Reviewed Original ResearchConceptsAdenylate cyclase-stimulating activityBone-resorbing activityTGF-like activityControl tumorsCell adenocarcinomaAnal sacDose-response curve parallelCyclase-stimulating activityC18 reverse-phase high-pressure liquid chromatographyResponsible mediatorsTumor extractsHigh-pressure liquid chromatographyReverse-phase high-pressure liquid chromatographyTumorsPressure liquid chromatographyAdenocarcinomaC18 RP-HPLCCurve parallelSacExtractHypercalcemiaLiquid chromatographyBPTHActivityResorption
1987
The relative potency of a human tumor‐derived PTH‐like adenylate cyclase‐stimulating preparation in three bioassays*
Stewart A, Wu T, Burtis W, Weir E, Broadus A, Insogna K. The relative potency of a human tumor‐derived PTH‐like adenylate cyclase‐stimulating preparation in three bioassays*. Journal Of Bone And Mineral Research 1987, 2: 37-43. PMID: 3455155, DOI: 10.1002/jbmr.5650020107.Peer-Reviewed Original ResearchConceptsFetal bone resorptionRat osteosarcomaPTH standardRelative potencyCyclase assaysPTH target tissuesAdenylate cyclase assayHumoral hypercalcemiaBone resorptionPTH receptorBPTH 1Target tissuesDistinct subpopulationsPotencyAssaysHypercalcemiaPrevious studiesMalignancyOsteosarcomaTumorsResorptionReceptors
1986
Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast
Baron R, Neff L, Roy C, Boisvert A, Caplan M. Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast. Cell 1986, 46: 311-320. PMID: 2424614, DOI: 10.1016/0092-8674(86)90748-8.Peer-Reviewed Original ResearchConceptsPlasma membraneOsteoclast plasma membraneBone resorptionBeta subunitProton translocationMonoclonal antibodiesImmunoblot analysisBone marrow cellsKidney tubule cellsExtracellular compartmentBone marrow preparationsMembraneMarrow cellsBone cellsTubule cellsCellsProton transportOsteoclast membraneMarrow preparationsIon transportOsteoclastsSodium pumpSpecific markersResorptionAntibodies
1984
Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia
Godsall J, Baron R, Insogna K. Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia. The American Journal Of Medicine 1984, 77: 747-750. PMID: 6486152, DOI: 10.1016/0002-9343(84)90378-4.Peer-Reviewed Original ResearchConceptsVitamin D metabolismD metabolismDihydroxyvitamin DBone histomorphometryNormal levelsAltered vitamin D metabolismPhosphate-binding antacidsVitamin D metabolitesHypophosphatemic osteomalaciaD metabolitesOsteomalaciaUndetectable levelsPatientsPossible roleHistomorphometryMetabolismMetabolitesHypophosphatemiaAntacidsPathogenesisIllnessResorptionElevated concentrationsLevelsIngestion
1980
The Viability of Rib Grafts Transplanted with the Periosteal Blood Supply
Ariyan S. The Viability of Rib Grafts Transplanted with the Periosteal Blood Supply. Plastic & Reconstructive Surgery 1980, 65: 140-151. PMID: 7352154, DOI: 10.1097/00006534-198002000-00004.Peer-Reviewed Original Research
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