1999
Student Research Award 1998: Cytokine‐mediated bone resorption is cytochrome P‐450 dependent
Young N, Chole R. Student Research Award 1998: Cytokine‐mediated bone resorption is cytochrome P‐450 dependent. Otolaryngology 1999, 121: 708-712. PMID: 10580224, DOI: 10.1053/hn.1999.v121.a101034.Peer-Reviewed Original ResearchConceptsCytokine-induced bone resorptionBone resorptionNitric oxideChronic otitis mediaCytochrome PBone lossOtitis mediaTumor necrosisInterleukin-1betaNO synthaseL-arginineBone remodelingResorptionPowerful inducerSelective inhibitorCytokinesPossible roleNOSConcomitant reductionBoneCellular eventsInhibitorsAlternative pathwayEssential cofactorMorbidity
1996
Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL
Wang W, Lu M, Hebert S. Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL. American Journal Of Physiology 1996, 271: c103-c111. PMID: 8760035, DOI: 10.1152/ajpcell.1996.271.1.c103.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCalciumCell MembraneCytochrome P-450 Enzyme SystemExtracellular SpaceFatty Acids, UnsaturatedIn Vitro TechniquesLoop of HenleNeomycinPatch-Clamp TechniquesPotassium Channel BlockersPotassium ChannelsProtein Kinase CRatsRats, Sprague-DawleyTetradecanoylphorbol AcetateConceptsThick ascending limbCell-attached patchesChannel activityProtein kinase CCytochrome PArachidonic acidControl valuesInhibitory effectPatch-clamp techniqueEffects of neomycinCalphostin CMicroM neomycinExtracellular Ca2Ascending limbAddition of phorbolRat kidneyChannel open probabilityTAL tubulesNM calphostin CInhibition of PKC
1989
Manipulation of cytochrome P-450 dependent renal thromboxane synthase activity in spontaneously hypertensive rats
Sessa W, Abraham N, Escalante B, Schwartzman M. Manipulation of cytochrome P-450 dependent renal thromboxane synthase activity in spontaneously hypertensive rats. Journal Of Hypertension 1989, 7: 37-42. PMID: 2708811, DOI: 10.1097/00004872-198901000-00006.Peer-Reviewed Original ResearchConceptsHeme oxygenase activityThromboxane synthase activityHypertensive ratsRenal heme oxygenase activitySeven-week-old SHRRenal cortical microsomesSystolic blood pressureMicrosomal heme oxygenase activityRenal cytochrome PCytochrome PSynthase activityThromboxane A2 formationCortical microsomesBlood pressureOxygenase activityBody weightA2 formationHemoprotein synthesisConsecutive daysControl levelsThromboxane synthaseSHRRatsHeme contentHeme availability
1986
The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P‐450; the past is prologue
Iversen P, Hines R, Bresnick E. The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P‐450; the past is prologue. BioEssays 1986, 4: 15-19. PMID: 3790107, DOI: 10.1002/bies.950040105.Peer-Reviewed Original ResearchConceptsRegulation of expressionEnzyme systemUbiquitous familySubstrate specificityGene expressionMultiple isozymesMolecular biologyCytochrome PToxic lesionsExogenous compoundsOxidative metabolismMechanisms of metabolismExpressionInducible cytochrome PIsozymesComplete understandingMetabolismBiochemical pharmacologyOrganismsBiologySpeciesRegulationWide varietyCascadeCurrent notions
1980
EVIDENCE FOR INHIBITORY COMPLEXES FORMED WITH CYTOCHROME P-450 AND A METABOLITE OF 1,1-DISUBSTITUTED HYDRAZINES11Supported by NIH Grant T32/GM07072 and Robert A. Welch Foundation Grant I-616.
Hines R, Prough R. EVIDENCE FOR INHIBITORY COMPLEXES FORMED WITH CYTOCHROME P-450 AND A METABOLITE OF 1,1-DISUBSTITUTED HYDRAZINES11Supported by NIH Grant T32/GM07072 and Robert A. Welch Foundation Grant I-616. 1980, 1215-1218. DOI: 10.1016/b978-0-12-187702-6.50117-1.Peer-Reviewed Original Research
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