2008
Association of Mycoplasma arthritidis Mitogen with Lethal Toxicity but Not with Arthritis in Mice
Luo W, Yu H, Cao Z, Schoeb T, Marron M, Dybvig K. Association of Mycoplasma arthritidis Mitogen with Lethal Toxicity but Not with Arthritis in Mice. Infection And Immunity 2008, 76: 4989-4998. PMID: 18779340, PMCID: PMC2573368, DOI: 10.1128/iai.00667-08.Peer-Reviewed Original ResearchConceptsCBA/J miceLethal toxicityHuman rheumatoid arthritisSeverity of arthritisMycoplasma arthritidis mitogenChronic arthritisRheumatoid arthritisHistopathological studyJ miceSystemic injectionDBA/2J miceArthritisPathogenic significanceMiceMitogenic activityMycoplasma arthritidisToxicityAcutePathogenesisSuperantigensArthritogenicityDiseaseSeverity
2006
Essential Role for Rac in Heregulin β1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4
Yang C, Liu Y, Lemmon MA, Kazanietz MG. Essential Role for Rac in Heregulin β1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4. Molecular And Cellular Biology 2006, 26: 831-842. PMID: 16428439, PMCID: PMC1347034, DOI: 10.1128/mcb.26.3.831-842.2006.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BlockingBreast NeoplasmsCell MovementCell ProliferationEnzyme ActivationErbB ReceptorsFemaleHumansNeoplasm ProteinsNeuregulin-1Phosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktReceptor, ErbB-2Receptor, ErbB-3Receptor, ErbB-4RNA Interferencesrc-Family KinasesTumor Cells, CulturedConceptsExtracellular signal-regulated kinaseHeregulin beta1RNA interferenceBreast cancer cellsCancer cellsActin cytoskeleton reorganizationDepletion of Rac1Activation of RacInactivation of RacTransactivation of EGFRSignal-regulated kinaseErbB receptor inhibitorsEpidermal growth factor receptorRho GTPasesMitogenic signalingRac activationRac GTPaseEpidermal growth factorGrowth factor receptorCytoskeleton reorganizationDownstream effectorsMitogenic activityCancer cell proliferationERK activationBreast cancer cell proliferation
2001
Hepatocyte growth factor is a mitogen for olfactory ensheathing cells
Yan H, Nie X, Kocsis J. Hepatocyte growth factor is a mitogen for olfactory ensheathing cells. Journal Of Neuroscience Research 2001, 66: 698-704. PMID: 11746390, PMCID: PMC2605377, DOI: 10.1002/jnr.10009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBrain Tissue TransplantationCell DivisionCell SizeCell SurvivalCells, CulturedColforsinCulture Media, Serum-FreeCyclic AMPDose-Response Relationship, DrugDrug InteractionsFemaleGlial Fibrillary Acidic ProteinHepatocyte Growth FactorImmunohistochemistryMitogensNeurogliaOlfactory BulbProto-Oncogene Proteins c-metRatsRats, WistarReceptor, Nerve Growth FactorS100 ProteinsTrauma, Nervous SystemConceptsHepatocyte growth factorActivity of HGFAdult rat olfactory bulbHGF/c-Met systemGrowth factorOEC proliferationMitogenic activityOlfactory Ensheathing CellsRat olfactory bulbAbility of HGFC-Met receptorAddition of forskolinCultured OECsOlfactory bulbVariety of cellsDNA synthesisC-MetSerum-free mediumPotential mitogenic activityPotent mitogenMulti-functional effectsImmunocytochemical analysisCell proliferationOlfactory systemOECs
1997
Glomerular epithelial cell products stimulate mesangial cell proliferation in culture
Budde K, Neumayer H, Salant D, Cybulsky A, Coleman D, Sterzel R. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney International 1997, 52: 733-741. PMID: 9291194, DOI: 10.1038/ki.1997.389.Peer-Reviewed Original ResearchConceptsGlomerular epithelial cellsMC growth factorsMesangial cellsGlomerular diseaseGrowth factorMesangial cell proliferationEpithelial cell productsQuiescent rat mesangial cellsRat mesangial cellsIL-6IL-4IL-5TNF-alphaIL-2Glomerular cell typesIL-1GM-CSFTGF betaSoluble factorsProliferative activityCell productsCompetitive binding assaysEpithelial cellsMitogenic activityCell proliferation
1996
Colony stimulating factor‐1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone‐related protein
Weir E, Lowik C, Paliwal I, Insogna K. Colony stimulating factor‐1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone‐related protein. Journal Of Bone And Mineral Research 1996, 11: 1474-1481. PMID: 8889847, DOI: 10.1002/jbmr.5650111014.Peer-Reviewed Original ResearchConceptsBone resorptionMature osteoclastsParathyroid hormoneOsteoclast precursorsFetal rat long bonesParathyroid hormone-related proteinResistant acid phosphatase-positive osteoclastsMitogenic activityFactor 1Hormone-related proteinOrgan cultureCSF-1Rat long bonesTreatment of boneSignificant increaseOrgan culture assayHistological examinationBone assayOsteoclast recruitmentOsteoclast formationRat osteoclastsColony stimulating factor 1CSF-1 productionPTHResorption
1992
Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates
Seedorf K, Millauer B, Kostka G, Schlessinger J, Ullrich A. Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates. Molecular And Cellular Biology 1992, 12: 4347-4356. DOI: 10.1128/mcb.12.10.4347-4356.1992.Peer-Reviewed Original ResearchNIH 3T3 cellsRas GTPase-activating proteinCarboxy-terminal amino acidsSignaling pathwayGTPase-activating proteinSignaling activityAmino acidsWild-type levelsPDGF-RSubstrates in vitroC-terminal truncationEGF-RReceptor signaling activityMitogenic activityPhosphotidylinositol 3-kinaseWild-type receptorBiological signaling activitiesSequence deletionsSubstrate phosphorylationCellular polypeptidesCellular proteinsCytoplasmic domainIntracellular sequencesSignaling potentialExtracellular domain
1989
Osteoblast-Like Cells Secrete Granulocyte-Macrophage Colony-Stimulating Factor in Response to Parathyroid Hormone and Lipopolysaccharide*
WEIR EC, INSOGNA KL, HOROWITZ MC. Osteoblast-Like Cells Secrete Granulocyte-Macrophage Colony-Stimulating Factor in Response to Parathyroid Hormone and Lipopolysaccharide*. Endocrinology 1989, 124: 899-904. PMID: 2643512, DOI: 10.1210/endo-124-2-899.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCell LineColony-Stimulating FactorsDNA ReplicationGranulocyte-Macrophage Colony-Stimulating FactorGrowth SubstancesInterleukin-2Interleukin-3Interleukin-4InterleukinsKineticsLipopolysaccharidesOsteoblastsOsteosarcomaParathyroid HormoneRatsRecombinant ProteinsThymidineConceptsGranulocyte-macrophage colony-stimulating factorInterleukin-2GM-CSF antibodyIL-4Colony-stimulating factorMitogenic activityCSF antibodiesROS cellsGM-CSFT-cell mitogenic activityPresence of antibodiesDose-dependent increaseHT-2 cellsBone resorptionOsteoblast-like cellsOsteoclast precursorsPTHCell CMLipopolysaccharideAntibodiesCellular mechanismsEffect of incubationCytokinesBiochemical criteriaCSF
1988
bFGF as an autocrine growth factor for human melanomas.
Halaban R, Kwon BS, Ghosh S, Delli Bovi P, Baird A. bFGF as an autocrine growth factor for human melanomas. Oncogene Research 1988, 3: 177-86. PMID: 3226725.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorNormal human melanocytesBFGF gene transcriptsHuman melanocytesGrowth factorAutocrine growth factorGene transcriptsHuman metastatic melanomaMolecular mechanismsFibroblast growth factorNormal melanocytesCyclic adenosine monophosphateSerum-containing mediumAnti-bFGF antibodyMelanoma cellsAbnormal expressionAdenosine monophosphateHuman melanomaMelanocytesRegular culture mediumDibutyryl cyclic adenosine monophosphateMitogenic activityCulture mediumCellsTranscripts
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply