2004
A Dynamic Molecular Link between the Telomere Length Regulator TRF1 and the Chromosome End Protector TRF2
Houghtaling BR, Cuttonaro L, Chang W, Smith S. A Dynamic Molecular Link between the Telomere Length Regulator TRF1 and the Chromosome End Protector TRF2. Current Biology 2004, 14: 1621-1631. PMID: 15380063, DOI: 10.1016/j.cub.2004.08.052.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, NorthernCell CycleFluorescent Antibody TechniqueHeLa CellsHumansImmunoprecipitationModels, BiologicalMolecular Sequence DataPlasmidsSequence Analysis, DNAShelterin ComplexTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 1Telomeric Repeat Binding Protein 2Two-Hybrid System TechniquesConceptsTelomerase-mediated telomere elongationTelomere length homeostasisBinding proteins TRF1Telomere length controlLength homeostasisTelomeric chromatinProteins TRF1Chromosome endsTelomere elongationHuman telomeresTankyrase 1TRF1TRF2Negative regulatorMolecular linkMolecular mechanismsCell cycleTelomeresDynamic cross talkTIN2Cross talkLength controlChromatinRegulatorProtein
2003
TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres
Chang W, Dynek JN, Smith S. TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres. Genes & Development 2003, 17: 1328-1333. PMID: 12782650, PMCID: PMC196064, DOI: 10.1101/gad.1077103.Peer-Reviewed Original ResearchConceptsSequential post-translational modificationsAccess of telomeraseDNA-binding proteinsPost-translational modificationsMammalian telomeresTelomeres resultsTranslational modificationsTankyrase 1TRF1Negative regulatorTelomeresADP-ribosylationNovel mechanismUnbound formUbiquitinationTelomere lengthUbiquitinProteasomeTelomeraseRegulatorProteolysisProteinDegradationElongation
2002
Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres
Cook BD, Dynek JN, Chang W, Shostak G, Smith S. Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human Telomeres. Molecular And Cellular Biology 2002, 22: 332-342. PMID: 11739745, PMCID: PMC134233, DOI: 10.1128/mcb.22.1.332-342.2002.Peer-Reviewed Original ResearchConceptsTankyrase 2Tankyrase 1Telomeric complexTelomeric DNA-binding proteinAccess of telomerasePolymerase tankyrase 1DNA-binding proteinsSpecialized reverse transcriptaseEndogenous TRF1Telomere maintenanceTelomeric functionPrimary human cellsRelated homologsPARP domainTelomeric DNAHuman telomeresTRF1TelomeresHuman cellsADP-ribosylationPARP assaysRecent identificationTelomeraseReverse transcriptaseOverexpression