William Chang, MD, PhD
Assistant Professor of Medicine (Nephrology)DownloadHi-Res Photo
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Nephrology
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Assistant Professor of Medicine (Nephrology)
Appointments
Nephrology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Nephrology Fellow
- Yale University (2012)
- Resident
- Yale New Haven Hospital (2008)
- Intern
- Yale New Haven Hospital (2007)
- PhD
- New York University, Oncology and Immunology (2006)
- MD
- New York University School of Medicine (2006)
- AB
- Harvard, Biology (1998)
Research
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Overview
Medical Research Interests
Biotechnology; Cell Biology; Kidney; Organoids
ORCID
0000-0002-7707-9242
Research at a Glance
Yale Co-Authors
Frequent collaborators of William Chang's published research.
Publications Timeline
A big-picture view of William Chang's research output by year.
Research Interests
Research topics William Chang is interested in exploring.
Jordan Pober, MD, PhD
Maria Figetakis
Alfred Bothwell, PhD
Diane Krause, MD, PhD
Francesc Lopez-Giraldez, PhD
Lawrence Young, MD
24Publications
1,717Citations
Publications
2026
Design and Implementation of a Simple In Vitro Microfluidic Platform for Culturing Kidney Tubular Cells in the Presence of Flow.
Asghari F, Graham M, Chang WG. Design and Implementation of a Simple In Vitro Microfluidic Platform for Culturing Kidney Tubular Cells in the Presence of Flow. ASAIO J 2026 PMID: 41975573, DOI: 10.1097/MAT.0000000000002712.Peer-Reviewed Original Research
2021
A therapeutic vascular conduit to support in vivo cell-secreted therapy
Han EX, Qian H, Jiang B, Figetakis M, Kosyakova N, Tellides G, Niklason LE, Chang WG. A therapeutic vascular conduit to support in vivo cell-secreted therapy. Npj Regenerative Medicine 2021, 6: 40. PMID: 34326344, PMCID: PMC8322381, DOI: 10.1038/s41536-021-00150-2.Peer-Reviewed Original ResearchCitationsAltmetricConceptsEnd-stage renal diseaseVascular conduitsLong-term efficacyVascular graftsHemoglobin levelsRenal diseaseCell-based therapiesMacrophage infiltrationCell transplantationHemodialysis accessAcellular vesselsLuminal obstructionSerum erythropoietinNude ratsClinical disordersCellular implantationEPO expressionErythropoietinGraftTherapyAdequate vascularizationBiological effectsHuman Amniotic Membrane as a Novel Scaffold for Inducible Pluripotent Stem Cell-derived Kidney Organoids
Figetakis M, James KJ, Kosyakova N, Torres R, Chang WG. Human Amniotic Membrane as a Novel Scaffold for Inducible Pluripotent Stem Cell-derived Kidney Organoids. ASAIO Journal 2021, 68: e73-e76. PMID: 35503644, PMCID: PMC9065564, DOI: 10.1097/mat.0000000000001476.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro
Kosyakova N, Kao DD, Figetakis M, López-Giráldez F, Spindler S, Graham M, James KJ, Won Shin J, Liu X, Tietjen GT, Pober JS, Chang WG. Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro. Npj Regenerative Medicine 2020, 5: 1. PMID: 31934351, PMCID: PMC6944695, DOI: 10.1038/s41536-019-0086-3.Peer-Reviewed Original ResearchCitationsAltmetric
2019
NSAID associated bilateral renal infarctions: a case report
Jeon Y, Lis JB, Chang WG. NSAID associated bilateral renal infarctions: a case report. International Journal Of Nephrology And Renovascular Disease 2019, 12: 177-181. PMID: 31447577, PMCID: PMC6682756, DOI: 10.2147/ijnrd.s212010.Peer-Reviewed Case Reports and Technical NotesCitationsConceptsNon-steroidal anti-inflammatory drugsRenal infarctionAnti-inflammatory drugsHigh-dose non-steroidal anti-inflammatory drugsRenal arterial blood flowBilateral renal infarctionYear old womanArterial blood flowPresence of NSAIDsNSAID useRenovascular vasoconstrictionRenal injuryVasoconstrictive effectRenal perfusionCase reportHigh prevalenceOlder womenBlood flowInfarctionCausative agentDrugsHypoperfusionVasoconstrictionPatientsInjuryTools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell Sources
Chang WG. Tools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell Sources. In R. L. Reis, & M. E. Gomes (Eds.), Encyclopedia of Tissue Engineering and Regenerative Medicine, Vol. 1 (pp. 199–208). Academic Press: Elsevier. (2019).Books
2017
A short discourse on vascular tissue engineering
Chang WG, Niklason LE. A short discourse on vascular tissue engineering. Npj Regenerative Medicine 2017, 2: 7. PMID: 29057097, PMCID: PMC5649630, DOI: 10.1038/s41536-017-0011-6.BooksCitationsAltmetric
2016
ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight 2016, 1: e80920. PMID: 27525311, PMCID: PMC4982472, DOI: 10.1172/jci.insight.80920.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMyocardial infarctionControl animalsCardiovascular progenitor cellsProgenitor cellsVentricular contractile functionCardiac repair strategiesNew blood vesselsInfarct areaLineage-tracing studiesContractile functionCardiac repairBlood vessel formationMyocardial regenerationEndothelial cellsHeart tissueBlood vesselsMurine heartInfarctionVessel formationInjuryMiceDelivery approachCardiomyocytesHeartCellsBlocking MHC class II on human endothelium mitigates acute rejection
Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight 2016, 1: e85293. PMID: 26900601, PMCID: PMC4756651, DOI: 10.1172/jci.insight.85293.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClass II MHC moleculesCytotoxic T lymphocytesII MHC moleculesClass I MHC moleculesMHC moleculesI MHC moleculesEndothelial cellsAcute rejectionT cellsEffector memory T cellsT cell-mediated destructionAcute allograft rejectionCell-mediated destructionGraft endothelial cellsMemory T cellsAlloreactive cytotoxic T lymphocytesExperimental rodent modelsMajor histocompatibility complex moleculesSecondary lymphoid organsMHC class IIClass I major histocompatibility complex moleculesAllogeneic human lymphocytesHistocompatibility complex moleculesPrevents CD4Artery graft
2015
Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli
Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS. Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli. Tissue Engineering Part A 2015, 21: 2673-2679. PMID: 26414101, PMCID: PMC4652181, DOI: 10.1089/ten.tea.2015.0060.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
Academic Achievements & Community Involvement
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Activities
activity American Society of Nephrology
2008 - PresentProfessional OrganizationsMemberactivity Harvard College
01/26/2026 - PresentPublic ServiceInterviewerDetailsUndergraduate admission intervieweractivity Charles H. Hood Foundation
10/17/2025 - 11/21/2025Peer Review Groups and Grant Study SectionsGrant Revieweractivity Research Science Institute
07/21/2025 - 07/29/2025Public ServiceVolunteerDetailsFinal Paper Readeractivity Tissue Engineering Approaches in Nephrology
02/10/2025 - PresentLectureVoegeli Lecture at the University of New HavenDetailsWest Haven, CT, United States
Honors
honor Kidney X: Artificial Kidney Prize
06/12/2023National AwardASN and HHSDetailsUnited Stateshonor Invited panelist
12/02/2021Regional AwardCharles H. Hood FoundationDetailsUnited Stateshonor Blavatnik Fund Semifinalist
11/06/2019Yale University AwardYale Blavatnik Fund for Innovation at YaleDetailsUnited Stateshonor Yale Center for Clinical Investigation, Junior Faculty Scholar
11/01/2012Yale University AwardYale UniversityDetailsUnited Stateshonor Scholar in Training Award for Special Conferences on Ubiquitination in Normal and Cancer Cells
11/01/2002National AwardAmerican Association of Cancer ResearchDetailsUnited States
Teaching & Mentoring
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Teaching
Clinical Yale Affiliated Hospitals Program
LecturerLecture SettingDetails8/1/2023 - PresentForHouse Staff1 Average Instructional Hours Per YearFull-time faculty of the Department of Internal Medicine at Yale provide a series of lectures (including residency noon conferences, subspecialty presentations, ward rounds, and grand rounds) at the nine other affiliated hospitals. These lectures comprise a major proportion of the education of the residents at the affiliated institutions.
Mentoring
Maria Eugenia Gulino
Postdoc2025 - PresentJay Manish Pandya
Postgrad associate2025 - PresentNaysa Kalugdan
Undergraduate Student2025 - PresentFatemeh Asghari
Postdoc2023 - Present
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