Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome
Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nature Aging 2020, 1: 124-141. PMID: 34796338, PMCID: PMC8597198, DOI: 10.1038/s43587-020-00002-6.Peer-Reviewed Original ResearchMeSH KeywordsDNA MethylationEpigenesis, GeneticEpigenomeHealthy AgingHumansMaleMiddle AgedMonocytesProteomicsConceptsDNA methylomeAge-associated transcriptional changesPromoters of lowlyDNA methylation profilingHuman classical monocytesCorresponding genesPrimary human cellsTranscriptional changesEpigenetic profilingDNA methylationCpG islandsProteomic alterationsSpecific signaturesHypermethylation eventsMethylation profilingHuman cellsMolecular programmingMethylomeGenesMetabolomics dataProfilingComprehensive characterizationHuman monocytesH3K4me1H3K27me3