Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis
Deng W, Chong B, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39260565, DOI: 10.1016/j.bpsc.2024.08.020.Peer-Reviewed Original ResearchClinical high riskCHR-PTrajectory groupsMaintenance of symptomsOnset of psychosisNon-convertersHealthy controlsDiagnostic constructSymptom trajectoriesPsychosisAffective comorbiditiesAssess symptomsHeightened riskFunctional impairmentSymptomsEtiological risk factorsFunctional outcomesImminent onsetLevels of intensityRemissionRisk factorsIndividualsPhase 3DistressImpairmentSex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis
Chintoh A, Liu L, Braun A, Akseer S, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, McGlashan T, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Addington J. Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis. Schizophrenia Research 2024, 271: 153-160. PMID: 39029145, DOI: 10.1016/j.schres.2024.07.030.Peer-Reviewed Original ResearchClinical high riskClinical high-risk individualsSex differencesNegative symptomsTransition to psychosisInvestigate sex differencesNo sex differencesSchizophreniform disorderCHR individualsPsychosisSubstance useSchizophreniaSymptomsHigh riskIndividualsSchizophreniformAnxietyClinical presentationSexDepressionDisordersBaselineDifferencesMaleYouth