Tyrone Cannon
Clark L. Hull Professor of Psychology and Professor of PsychiatryCards
About
Research
Publications
2025
Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity
Mason A, Palmer W, Cao H, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Mathalon D, Walker E, Woods S, Cannon T. Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity. Schizophrenia Research 2025, 281: 115-121. PMID: 40328092, DOI: 10.1016/j.schres.2025.04.034.Peer-Reviewed Original ResearchConceptsInferior parietal lobe activityPsychotic symptom severityParietal lobe activityDevelopmental traumaDelusion severityHallucination severityMemory taskNeurocognitive measuresMemory processesMemory performanceSymptom severityScale of Psychosis-risk SymptomsNorth American Prodrome Longitudinal StudyPoorer episodic memory performanceRisk of psychotic symptomsPaired-associate memory taskAssociated with memory processingMemory-associated regionsTrauma-exposed individualsEpisodic memory processesEpisodic memory tasksPsychosis-risk symptomsClinical high riskEpisodic memory performanceSubclinical delusionsTrajectories of positive symptoms and suicidality in individuals at clinical high risk for psychosis
Deng W, MacNutt C, Addington J, Bearden C, Cadenhead K, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Trajectories of positive symptoms and suicidality in individuals at clinical high risk for psychosis. Journal Of Affective Disorders 2025, 384: 208-213. PMID: 40334865, DOI: 10.1016/j.jad.2025.05.023.Peer-Reviewed Original ResearchConceptsPositive symptomsClinical high riskSuicidal ideationCHR-PMeasures of suicidal ideationEarly stages of psychosisPersistence of suicidal ideationSeverity of depressive symptomsPositive symptom severityAssessment timepointsCHR-P participantsEmergence of suicidalityStages of psychosisCHR-P populationTargeted suicide prevention strategiesPsychotic disordersEarly psychosisSuicide prevention strategiesDepressive symptomsSymptom severityPsychosisIdeationDelusionsSuicideHallucinationsMismatch Negativity as a Predictor of Future Outcomes Among Individuals at Clinical High-Risk for Psychosis: Parsing Components of Auditory Predictive Coding in the North American Psychosis-Risk Longitudinal Study (NAPLS3) Sample
Hamilton H, Nicholas S, Hua J, Roach B, Belger A, Carrion R, Duncan E, Johannesen J, Keshavan M, Loo S, Niznikiewicz M, Light G, Billah T, Lavoie S, Whitford T, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Mathalon D, Schizophrenia A. Mismatch Negativity as a Predictor of Future Outcomes Among Individuals at Clinical High-Risk for Psychosis: Parsing Components of Auditory Predictive Coding in the North American Psychosis-Risk Longitudinal Study (NAPLS3) Sample. Biological Psychiatry 2025, 97: s69. DOI: 10.1016/j.biopsych.2025.02.180.Peer-Reviewed Original Research571. Preliminary Findings on the Association Between Psychotropic Medication and Symptom Profile Changes in Youth at Clinical High Risk for Psychosis
Zhou Q, Ananth A, Yuan E, Ku B, Goldsmith D, Addington J, Bearden C, Cadenhead K, Mukhtar H, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. 571. Preliminary Findings on the Association Between Psychotropic Medication and Symptom Profile Changes in Youth at Clinical High Risk for Psychosis. Biological Psychiatry 2025, 97: s333-s334. DOI: 10.1016/j.biopsych.2025.02.810.Peer-Reviewed Original Research528. Characterizing White Matter Alterations in Youth at Clinical High Risk for Psychosis
Kang J, Schleifer C, Amir C, Fung H, Chang S, Boen R, Villalón-Reina J, Di Biase M, Pasternak O, Addington J, Anticevic A, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Karlsgodt K, Bearden C. 528. Characterizing White Matter Alterations in Youth at Clinical High Risk for Psychosis. Biological Psychiatry 2025, 97: s315. DOI: 10.1016/j.biopsych.2025.02.767.Peer-Reviewed Original Research511. Associations of Cognitive Functions With EEG-Based Event-Related Potentials and Oscillations in Individuals at Clinical High-Risk for Psychosis: A Canonical Correlation Analysis of NAPLS2 Data
Hua J, Roach B, Hamilton H, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Shapiro D, Woodberry K, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Mathalon D. 511. Associations of Cognitive Functions With EEG-Based Event-Related Potentials and Oscillations in Individuals at Clinical High-Risk for Psychosis: A Canonical Correlation Analysis of NAPLS2 Data. Biological Psychiatry 2025, 97: s308. DOI: 10.1016/j.biopsych.2025.02.750.Peer-Reviewed Original ResearchResponse to Psychotherapy by Clients With Varying Levels of Distress Treated in a Graduate Student Outpatient Clinic
O’Brien M, O’Leary C, Cannon T, Lympus C, Salinger J, Prelli F, Gale M. Response to Psychotherapy by Clients With Varying Levels of Distress Treated in a Graduate Student Outpatient Clinic. Training And Education In Professional Psychology 2025, 19: 124-133. DOI: 10.1037/tep0000508.Peer-Reviewed Original ResearchOutcome Questionnaire-45Levels of distressResponse to psychotherapyPositive therapeutic allianceIndividual psychotherapyCognitive reappraisalPerseverative thinkingTherapeutic allianceSelf-compassionTraining clinicTherapeutic relationshipPsychological processesPsychological skillsPsychotherapyCourse of treatmentEnd treatmentRepeated-measures analysisRepeated-measures analysis of varianceDistressContext variablesRepeated-measuresClientsAnalysis of varianceDoctoral studentsOutpatient clinicA “Hyper-Recency” Bias in Memory Characterizes Both Psychoticism and Déjà Vu Experiences
Koller W, Ongchoco J, Bronstein M, Scholl B, Cannon T. A “Hyper-Recency” Bias in Memory Characterizes Both Psychoticism and Déjà Vu Experiences. Journal Of Experimental Psychology General 2025, 154: 1428-1444. PMID: 40372909, DOI: 10.1037/xge0001754.Peer-Reviewed Original ResearchConceptsPsychosis-like symptomsRecognition memory judgmentsLevels of psychoticismMemory judgmentsCognitive correlatesNovel stimuliCognitive processesPreregistered experimentsGeneral populationPsychoticismDeja VuPsychosisSubjective experienceStimuliRecencyMemorySymptomsReduced differentiationConflictJudgmentBiasParticipantsSource of conflictIllusionHigh rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention
Trujillo T, Mirzakhanian H, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. High rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention. Schizophrenia Research 2025, 281: 1-9. PMID: 40300257, DOI: 10.1016/j.schres.2025.04.030.Peer-Reviewed Original ResearchConceptsClinical high riskCalgary Depression Scale for SchizophreniaClinical high-risk youthSuicide risk assessmentParasuicidal behaviorSuicidal ideationLife eventsSelf-harmNorth American Prodrome Longitudinal StudyClinical high-risk participantsStructured Assessment of Violence RiskAssessment of Violence RiskClinical high-risk groupHealthy controlsRates of suicidal ideationHistory of self-harmHistory of SILevels of suicidalityStressful life eventsPredictors of SIRates of suicideAssociated with worse symptomsCHR participantsPsychotic conversionDSM diagnosesCultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis
Guest R, Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. Cultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis. Schizophrenia Research 2025, 280: 60-68. PMID: 40250131, PMCID: PMC12169887, DOI: 10.1016/j.schres.2025.04.019.Peer-Reviewed Original ResearchConceptsMATRICS Consensus Cognitive BatteryConsensus Cognitive BatteryClinical high riskCognitive batteryCHR-PHopkins Verbal Learning Test-RevisedNorth American Prodrome Longitudinal StudyEnglish speakersHealthy controlsLetter-Number SpanPsychosis-Risk SyndromesMultigroup structural equation modelingInfluence cognitive performanceCultural variablesNative English speakersSample of peopleLetter-NumberNeuropsychological measuresVariables influencing performanceTest-RevisedCognitive performanceStructural equation modelingAnimal namesDiagnostic groupsCanadian sample