Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder
Song J, Pasman J, Johansson V, Kuja-Halkola R, Harder A, Karlsson R, Lu Y, Kowalec K, Pedersen N, Cannon T, Hultman C, Sullivan P. Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder. JAMA Psychiatry 2024, 81 PMID: 39196586, PMCID: PMC11359115, DOI: 10.1001/jamapsychiatry.2024.2406.Peer-Reviewed Original ResearchPolygenic risk scoresGenome-wide association studiesSwedish Twin RegistryBipolar disorderCase-control studyTwin concordanceTwin heritabilityLevels of polygenic risk scoreTwin RegistrySwedish national register dataCompare polygenic risk scoresRisk scoreNational register dataHeritable psychiatric disorderAffected co-twinsPairs of twinsPsychosis phenotypeIllness vulnerabilityClinical interviewPsychiatric disordersGenetic liabilityMain OutcomesStructural equation modelingPsychosisSchizophreniaGenetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health
Kouakou M, Cabrera-Mendoza B, Pathak G, Cannon T, Polimanti R. Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health. Schizophrenia Bulletin 2024, sbae093. PMID: 38848523, DOI: 10.1093/schbul/sbae093.Peer-Reviewed Original ResearchMultivariable Mendelian randomizationMR analysisMedical endpointsMultivariable MR analysisNegative health outcomesSubstance usePsychiatric Genomics ConsortiumHigh-risk individualsFinnGen participantsMendelian randomizationMultiple testing correctionSocioeconomic inequalitiesHealth outcomesBonferroni multiple testing correctionUK BiobankSocioeconomic differencesPhysical healthMental healthAnalysis of schizophreniaGenetic liabilityAdjustment disorderHousehold incomeLife expectancyTesting correctionPersonality disorder