Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis
Schleifer C, Chang S, Amir C, O'Hora K, Fung H, Kang J, Kushan-Wells L, Daly E, Di Fabio F, Frascarelli M, Gudbrandsen M, Kates W, Murphy D, Addington J, Anticevic A, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Uddin L, Kumar K, Hoftman G, Bearden C. Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis. Biological Psychiatry 2024 PMID: 39181389, DOI: 10.1016/j.biopsych.2024.08.010.Peer-Reviewed Original ResearchBrain signal variabilityClinical high riskCHR individualsTD controlsSubthreshold psychosis symptomsResting-state functional MRIFunctional brain alterationsAssociated with psychosisFunctional brain measuresGroup difference mapCopy number variantsCase-control differencesPsychosis symptomsNeural substratesBrain alterationsBrain measuresLocal connectivityFunctional MRIFunctional connectivityCortical regionsNeuroimaging signaturesNeurodevelopmental disordersPsychosisHigh riskBrain mappingWhole genome sequencing study of identical twins discordant for psychosis
Ormond C, Ryan N, Hedman A, Cannon T, Sullivan P, Gill M, Hultman C, Heron E, Johansson V, Corvin A. Whole genome sequencing study of identical twins discordant for psychosis. Translational Psychiatry 2024, 14: 313. PMID: 39080272, PMCID: PMC11289105, DOI: 10.1038/s41398-024-02982-0.Peer-Reviewed Original ResearchConceptsCopy number variantsSequencing studiesGenic copy number variantsWhole-genome sequencing studiesRare genic copy number variantsDeleterious missense variantsWhole-genome sequencingExome sequencing studiesGenome sequencing studiesMZ twinsPost-zygotic eventsPairs of MZ twinsGenome sequenceIdentical genomesDNA variantsMissense variantsOverlapped genesPsychotic phenotypesPsychotic disordersBipolar disorderRare variantsMZ twin studiesPhenotypic discordanceTwin studiesTwin pairs