Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis
Schleifer C, Chang S, Amir C, O'Hora K, Fung H, Kang J, Kushan-Wells L, Daly E, Di Fabio F, Frascarelli M, Gudbrandsen M, Kates W, Murphy D, Addington J, Anticevic A, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Uddin L, Kumar K, Hoftman G, Bearden C. Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis. Biological Psychiatry 2024 PMID: 39181389, DOI: 10.1016/j.biopsych.2024.08.010.Peer-Reviewed Original ResearchBrain signal variabilityClinical high riskCHR individualsTD controlsSubthreshold psychosis symptomsResting-state functional MRIFunctional brain alterationsAssociated with psychosisFunctional brain measuresGroup difference mapCopy number variantsCase-control differencesPsychosis symptomsNeural substratesBrain alterationsBrain measuresLocal connectivityFunctional MRIFunctional connectivityCortical regionsNeuroimaging signaturesNeurodevelopmental disordersPsychosisHigh riskBrain mappingSex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis
Chintoh A, Liu L, Braun A, Akseer S, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, McGlashan T, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Addington J. Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis. Schizophrenia Research 2024, 271: 153-160. PMID: 39029145, DOI: 10.1016/j.schres.2024.07.030.Peer-Reviewed Original ResearchClinical high riskClinical high-risk individualsSex differencesNegative symptomsTransition to psychosisInvestigate sex differencesNo sex differencesSchizophreniform disorderCHR individualsPsychosisSubstance useSchizophreniaSymptomsHigh riskIndividualsSchizophreniformAnxietyClinical presentationSexDepressionDisordersBaselineDifferencesMaleYouth