Featured Publications
The anterior cingulate cortex is necessary for forming prosocial preferences from vicarious reinforcement in monkeys
Basile BM, Schafroth JL, Karaskiewicz CL, Chang SWC, Murray EA. The anterior cingulate cortex is necessary for forming prosocial preferences from vicarious reinforcement in monkeys. PLOS Biology 2020, 18: e3000677. PMID: 32530910, PMCID: PMC7292358, DOI: 10.1371/journal.pbio.3000677.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChoice BehaviorGyrus CinguliMacaca mulattaMalePupilReinforcement, PsychologySocial BehaviorConceptsAnterior cingulate cortexProsocial preferencesVicarious reinforcementCingulate cortexACC lesionsPrimate anterior cingulate cortexSocial preferencesDifferent visual cuesSocial cognitionReward outcomesReinforcement taskReward deliveryVisual cuesACC contributionSocial outcomesCuesSocial relationshipsExcitotoxic lesionsPeripheral targetsGood thingGreater tendencySelfCortexLesion groupSingle neuronsSpecialized medial prefrontal–amygdala coordination in other-regarding decision preference
Dal Monte O, Chu CCJ, Fagan NA, Chang SWC. Specialized medial prefrontal–amygdala coordination in other-regarding decision preference. Nature Neuroscience 2020, 23: 565-574. PMID: 32094970, PMCID: PMC7131896, DOI: 10.1038/s41593-020-0593-y.Peer-Reviewed Original ResearchConceptsMultiple cognitive operationsRostral anterior cingulate gyrusMedial prefrontal cortexSubcortical brain regionsAnterior cingulate gyrusCognitive operationsGamma frequency bandSocial decisionsSpecialized coordinationPrefrontal cortexNegative ORPSocial behaviorNeural populationsCingulate gyrusBrain regionsBasolateral amygdalaNetwork interactDecision preferencesSpecific directionalityNeuronal interactionsRewardGyrusAmygdalaPreferencesCortexOxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte O, Piva M, Anderson KM, Tringides M, Holmes AJ, Chang SWC. Oxytocin under opioid antagonism leads to supralinear enhancement of social attention. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 5247-5252. PMID: 28461466, PMCID: PMC5441805, DOI: 10.1073/pnas.1702725114.Peer-Reviewed Original ResearchConceptsSocial attentionMutual eye contactSocial cognitionReward receiptParticular social importanceEfficacy of oxytocinEye contactSocial dysfunctionOpioid antagonismSocial contextGaze interactionHuman brainEntire sessionOxytocinΚ-opioid receptor geneFacial regionOT geneAttentionCognitionSocial importanceStrong effectMonkeysOpioid systemSessionsContext
2021
Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates
Weinberg-Wolf HB, Fagan N, Dal Monte O, Chang SWC. Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates. Journal Of Neuroscience 2021, 42: 670-681. PMID: 34862190, PMCID: PMC8805615, DOI: 10.1523/jneurosci.0413-21.2021.Peer-Reviewed Original ResearchConceptsSocial gaze behaviorAbility of monkeysSocial gazeGaze behaviorMotivational stateControl imagesReaction timeCentral serotonin levelsNonhuman primatesSocial orientingGaze responsesSerotonergic interventionsModulatory relationshipCausal evidenceEye movementsTranslational insightsGazeDistinct aspectsDisruptive effectsBehavioral changesSerotonergic systemPupil constrictionCausal impactCentral serotoninFlexible orientationDisentangling perceptual awareness from nonconscious processing in rhesus monkeys (Macaca mulatta)
Ben-Haim MS, Dal Monte O, Fagan NA, Dunham Y, Hassin RR, Chang SWC, Santos LR. Disentangling perceptual awareness from nonconscious processing in rhesus monkeys (Macaca mulatta). Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2017543118. PMID: 33785543, PMCID: PMC8053918, DOI: 10.1073/pnas.2017543118.Peer-Reviewed Original Research
2018
The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque
Weinberg-Wolf H, Fagan NA, Anderson GM, Tringides M, Dal Monte O, Chang SWC. The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque. Neuropsychopharmacology 2018, 43: 1589-1598. PMID: 29463909, PMCID: PMC5983545, DOI: 10.1038/s41386-017-0003-7.Peer-Reviewed Original ResearchConceptsSerotonergic interventionsSalient facial featuresCentral serotonergic functioningCisternal cerebrospinal fluidBaseline attentionCognitive operationsSerotonin's roleIndividual differencesBi-directional effectsAutonomic arousalSaline sessionsImmediate serotonin precursorEngaged individualsBehavioral impairmentsFacial featuresSerotonergic functioningStimulus animalsRole of serotoninPupil sizeAnxietyPsychiatric disordersSerotonin neurochemistrySerotoninergic functionSerotonin effectsCSF concentrations
2016
Live interaction distinctively shapes social gaze dynamics in rhesus macaques
Dal Monte O, Piva M, Morris JA, Chang SW. Live interaction distinctively shapes social gaze dynamics in rhesus macaques. Journal Of Neurophysiology 2016, 116: 1626-1643. PMID: 27486105, PMCID: PMC5144716, DOI: 10.1152/jn.00442.2016.Peer-Reviewed Original ResearchConceptsMutual eye contactGaze dynamicsEye contactSocial cognitionProportion of fixationsInteractive social contextsPairs of monkeysFocal attentionSustained attentionLive interactionEye regionSeparable componentsFamiliar pairsMeaningful eventsSocial contextReal partnersDominant monkeysSame monkeysCognitionStatic imagesReal-time interactionAttentionMonkeys
2012
Neuronal reference frames for social decisions in primate frontal cortex
Chang SW, Gariépy JF, Platt ML. Neuronal reference frames for social decisions in primate frontal cortex. Nature Neuroscience 2012, 16: 243-250. PMID: 23263442, PMCID: PMC3557617, DOI: 10.1038/nn.3287.Peer-Reviewed Original ResearchInhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta)
Chang SW, Barter JW, Ebitz RB, Watson KK, Platt ML. Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta). Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 959-964. PMID: 22215593, PMCID: PMC3271866, DOI: 10.1073/pnas.1114621109.Peer-Reviewed Original ResearchConceptsDelivery of rewardTypical social behaviorsProsocial choicesDecision latenciesObservational learningSpecies-typical social behaviorsNeural mechanismsSelfish choicesVicarious reinforcementSocial behaviorDistinct contextsDonation behaviorHuman behaviorNeural modelRewardSocial awarenessSelf-ReinforcementOxytocinPrairie volesSelfMonogamous onesRhesus macaquesOwn experienceEmpathyAttention