Featured Publications
Prefrontal–amygdala circuits in social decision-making
Gangopadhyay P, Chawla M, Dal Monte O, Chang SWC. Prefrontal–amygdala circuits in social decision-making. Nature Neuroscience 2020, 24: 5-18. PMID: 33169032, PMCID: PMC7899743, DOI: 10.1038/s41593-020-00738-9.Peer-Reviewed Original ResearchConceptsSocial behaviorSystems neuroscience perspectivePrefrontal-amygdala pathwaysPrefrontal-amygdala circuitsPrefrontal cortical regionsSocial cognitionNeuroscience perspectiveNeural basisNeuropeptide oxytocinBrains of primatesNeural mechanismsCortical regionsNon-human primatesSpecific instantiationSocial constructMultiple levelsCognitionNeuronal activityMultiple animal speciesNeurobiologyAmygdalaBehaviorUnderpinningsPrimatesConstructs
2022
Prefrontal circuits guiding social preference: Implications in autism spectrum disorder
Fortier AV, Meisner OC, Nair AR, Chang SWC. Prefrontal circuits guiding social preference: Implications in autism spectrum disorder. Neuroscience & Biobehavioral Reviews 2022, 141: 104803. PMID: 35908593, PMCID: PMC10122914, DOI: 10.1016/j.neubiorev.2022.104803.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderUnderlying neural mechanismsSpectrum disorderTreatment developmentSocial preferencesSocial preference behaviorSocial cognitionUnderlying neural circuitsAtypical developmentNeural mechanismsPrefrontal circuitsCircuit-level dysfunctionBehavioral disruptionNeural circuitsBehavioral deficitsAnimal model researchAnimal modelsCommon circuitsDiagnostic prevalenceConvergent circuitClinical presentationNeurological alterationsTreatment optionsEffects of dysregulationCognition
2012
Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta)
Chang SW, Barter JW, Ebitz RB, Watson KK, Platt ML. Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta). Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 959-964. PMID: 22215593, PMCID: PMC3271866, DOI: 10.1073/pnas.1114621109.Peer-Reviewed Original ResearchConceptsDelivery of rewardTypical social behaviorsProsocial choicesDecision latenciesObservational learningSpecies-typical social behaviorsNeural mechanismsSelfish choicesVicarious reinforcementSocial behaviorDistinct contextsDonation behaviorHuman behaviorNeural modelRewardSocial awarenessSelf-ReinforcementOxytocinPrairie volesSelfMonogamous onesRhesus macaquesOwn experienceEmpathyAttention