Closed-loop microstimulations of the orbitofrontal cortex during real-life gaze interaction enhance dynamic social attention
Fan S, Dal Monte O, Nair A, Fagan N, Chang S. Closed-loop microstimulations of the orbitofrontal cortex during real-life gaze interaction enhance dynamic social attention. Neuron 2024, 112: 2631-2644.e6. PMID: 38823391, PMCID: PMC11309918, DOI: 10.1016/j.neuron.2024.05.004.Peer-Reviewed Original ResearchPrimate prefrontal cortexPrefrontal cortexSocial attentionOrbitofrontal cortexDorsomedial prefrontal cortexAnterior cingulate cortexCingulate cortexDirect gazeGaze interactionCortexGaze dynamicsControl different aspectsDistance of fixationDifferent aspectsGaze eventsPartner eyeGazeMultiple regionsMicrostimulationGaze positionAttentionSpatial dimensionsLatencyNeuronsOxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte O, Piva M, Anderson KM, Tringides M, Holmes AJ, Chang SWC. Oxytocin under opioid antagonism leads to supralinear enhancement of social attention. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 5247-5252. PMID: 28461466, PMCID: PMC5441805, DOI: 10.1073/pnas.1702725114.Peer-Reviewed Original ResearchConceptsSocial attentionMutual eye contactSocial cognitionReward receiptParticular social importanceEfficacy of oxytocinEye contactSocial dysfunctionOpioid antagonismSocial contextGaze interactionHuman brainEntire sessionOxytocinΚ-opioid receptor geneFacial regionOT geneAttentionCognitionSocial importanceStrong effectMonkeysOpioid systemSessionsContext