Featured Publications
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerceptionDissociation of vicarious and experienced rewards by coupling frequency within the same neural pathway
Putnam P, Chu C, Fagan N, Dal Monte O, Chang S. Dissociation of vicarious and experienced rewards by coupling frequency within the same neural pathway. Neuron 2023, 111: 2513-2522.e4. PMID: 37348507, PMCID: PMC10527039, DOI: 10.1016/j.neuron.2023.05.020.Peer-Reviewed Original ResearchConceptsExperienced rewardsVicarious rewardBasolateral amygdalaAlpha/beta frequencyLocal field potentialsSame neural pathwaysSelect brain regionsSocial learningNeural systemsSocial interactionDirectional influenceRewardBrain regionsBeta frequenciesNeural pathwaysGamma frequenciesShared experienceDecision makingNeuronal interactionsSocial agencyField potentialsVoluntary choiceSocial choiceGyrusAmygdalaWidespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks
Dal Monte O, Fan S, Fagan NA, Chu CJ, Zhou MB, Putnam PT, Nair AR, Chang SWC. Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks. Neuron 2022, 110: 2183-2197.e7. PMID: 35545090, PMCID: PMC9262836, DOI: 10.1016/j.neuron.2022.04.013.Peer-Reviewed Original ResearchSpecialized medial prefrontal–amygdala coordination in other-regarding decision preference
Dal Monte O, Chu CCJ, Fagan NA, Chang SWC. Specialized medial prefrontal–amygdala coordination in other-regarding decision preference. Nature Neuroscience 2020, 23: 565-574. PMID: 32094970, PMCID: PMC7131896, DOI: 10.1038/s41593-020-0593-y.Peer-Reviewed Original ResearchConceptsMultiple cognitive operationsRostral anterior cingulate gyrusMedial prefrontal cortexSubcortical brain regionsAnterior cingulate gyrusCognitive operationsGamma frequency bandSocial decisionsSpecialized coordinationPrefrontal cortexNegative ORPSocial behaviorNeural populationsCingulate gyrusBrain regionsBasolateral amygdalaNetwork interactDecision preferencesSpecific directionalityNeuronal interactionsRewardGyrusAmygdalaPreferencesCortex
2021
Toward a holistic view of value and social processing in the amygdala: Insights from primate behavioral neurophysiology
Putnam PT, Chang SWC. Toward a holistic view of value and social processing in the amygdala: Insights from primate behavioral neurophysiology. Behavioural Brain Research 2021, 411: 113356. PMID: 33989727, PMCID: PMC8238892, DOI: 10.1016/j.bbr.2021.113356.Peer-Reviewed Original ResearchConceptsSocial behaviorSocial stimuliValue-related processesNegative emotional processesAspects of cognitionReward-related processesDistinct brain regionsSocial processingEmotional processesAmygdala's roleNeural basisPositive affectHolistic hypothesisPrimate neurophysiologyNeurophysiological mechanismsBehavioral neurophysiologySocial interactionValue processingModern neuroscienceTemporal lobeBrain regionsAmygdalaStimuliNeurophysiologyProcessingSocial processing by the primate medial frontal cortex
Putnam PT, Chang SWC. Social processing by the primate medial frontal cortex. International Review Of Neurobiology 2021, 158: 213-248. PMID: 33785146, PMCID: PMC8232543, DOI: 10.1016/bs.irn.2020.12.003.Peer-Reviewed Original ResearchConceptsPrimate medial frontal cortexMedial frontal cortexFrontal cortexSocial interactionSocial behaviorSocial information processingAdaptive social interactionsNon-social behaviorsComplex social behaviorsSocial processingInformation processing systemsNeurophysiology literatureVicarious learningSocial partnersInformation processingSocial monitoringNeuronal substratesBrain regionsUnique contributionNeurophysiology experimentsSocial functionCortexNeural algorithmDecision-making processNonhuman primates