Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
Hatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, Bertozzi CR. Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: e5069-e5077. PMID: 24309377, PMCID: PMC3876250, DOI: 10.1073/pnas.1321205110.Peer-Reviewed Original ResearchConceptsEukaryotic-like Ser/Thr protein kinasesSer/Thr protein kinaseOsmotic stressProtein kinaseCell wall remodelingAlternative σ factorsVirulence factor productionΣ factorsTranscriptional programsSecretion systemESX-1 secretion systemBroader roleWall remodelingWidespread occurrenceKinaseBacteriaPhysiological changesFactor productionPathwayDifferent microenvironmentsAntibiotic resistanceOsmosensingRegulonPknDMycobacterium tuberculosis