Stavroula Hatzios, PhD
she/her/hers
Associate Professor of Molecular, Cellular and Developmental Biology and of ChemistryDownloadHi-Res Photo
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About
Titles
Associate Professor of Molecular, Cellular and Developmental Biology and of Chemistry
Appointments
Chemistry
Associate Professor on TermSecondary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Brigham and Women's Hospital/Harvard Medical School (2016)
- PhD
- University of California, Berkeley, Chemistry (2010)
- BS
- Massachusetts Institute of Technology, Chemistry (2005)
Research
Overview
Medical Research Interests
Bacteria; Biochemistry; Enzyme Activation; Gastrointestinal Diseases; Host-Pathogen Interactions; Microbiology; Oxidative Stress
ORCID
0000-0001-8658-8949- View Lab Website
Hatzios Lab
Publications
2025
An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology
Seminara A, Hatzios S. An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology. Cell Chemical Biology 2025, 32: 486-497.e7. PMID: 40068683, DOI: 10.1016/j.chembiol.2025.02.004.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsGastric pathogen Helicobacter pyloriHost-associated microbesOuter membrane transportersWild-type H. pyloriTransporter-deficient strainsPathogen Helicobacter pyloriNutrient-rich mediumBacterial physiologyMicrobial physiologyErgothioneine biosynthesisBacterial speciesMicrobial strainsComplex mediaCulture H. pyloriErgothioneineStrainHelicobacter pyloriPhysiologyH. pyloriComplicating effortsBiosynthesisTranscriptionFungalMicrobesHuman diet
2024
Microbial metabolism of host-derived antioxidants
Zhou Z, Hatzios S. Microbial metabolism of host-derived antioxidants. Current Opinion In Chemical Biology 2024, 84: 102565. PMID: 39721219, PMCID: PMC11863140, DOI: 10.1016/j.cbpa.2024.102565.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsThoughts for the future
Alkhalaf L, Arrowsmith C, Balskus E, Bergamini G, Bhandari R, Chang C, Chen P, Chen X, Ciulli A, Cricco J, Davis B, Delbianco M, Dudareva N, Dueber E, Ferguson F, de Giuseppe P, Hamachi I, Hammond M, Hatzios S, Do Heo W, Janet J, Kamat S, Knapp S, Krishnan Y, Lang K, Laraia L, Leveson-Gower R, Li X, Liu D, Liu M, London N, Mahanta N, Mayor-Ruiz C, Muir T, Murakami M, Rhee H, Robers M, Satz A, Schulman B, Shen B, Shoichet B, Strauss E, Suzuki T, Tiwary P, Waldmann H, Ward T, Weeks A, Weerapana E, Winter G. Thoughts for the future. Nature Chemical Biology 2024, 21: 6-15. PMID: 39719500, DOI: 10.1038/s41589-024-01802-2.Peer-Reviewed Original ResearchCitationsAltmetricCall for Papers: The Role of Microbiota in Infection and Immunity
Griffin M, Hatzios S, Qiao Y. Call for Papers: The Role of Microbiota in Infection and Immunity. ACS Infectious Diseases 2024, 10: 3714-3714. DOI: 10.1021/acsinfecdis.4c00841.Peer-Reviewed Original ResearchAltmetric
2023
Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection
Baskerville M, Kovalyova Y, Mejías-Luque R, Gerhard M, Hatzios S. Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection. PLOS Pathogens 2023, 19: e1011526. PMID: 37494402, PMCID: PMC10406306, DOI: 10.1371/journal.ppat.1011526.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsH. pylori infectionPylori infectionInfected cellsBacterial catabolismGastric pathogen Helicobacter pyloriGSH depletionPathogen Helicobacter pyloriH. pylori-infected cellsMammalian cellsReactive oxygen speciesHelicobacter pylori infectionH. pylori colonizationCellular biomoleculesGSH homeostasisBacterial acquisitionCertain bacteriaVirulence factorsAntioxidant glutathioneIntracellular GSHOxidative damageOxidized GSHΓ-glutamyl transpeptidaseIsotope tracingHost tissuesOxygen speciesMoonlighting in the membrane
Hatzios S. Moonlighting in the membrane. Nature Chemical Biology 2023, 19: 1436-1437. PMID: 37349584, DOI: 10.1038/s41589-023-01369-4.Commentaries, Editorials and LettersEmerging roles of low-molecular-weight thiols at the host–microbe interface
Dumitrescu D, Hatzios S. Emerging roles of low-molecular-weight thiols at the host–microbe interface. Current Opinion In Chemical Biology 2023, 75: 102322. PMID: 37201290, PMCID: PMC10524283, DOI: 10.1016/j.cbpa.2023.102322.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHost-microbe interfaceLMW thiolsWeight thiolsCellular redox homeostasisRedox-active metabolitesCellular physiologyVirulence regulationRedox homeostasisHost physiologyAbundant classMicrobial metabolismHost cellsIntercellular interactionsForms of lifeInfected cellsSmall moleculesPhysiologyCellsComputational approachThiolsHomeostasisRegulationRoleMetabolismDiscoveryActivity‐based Tools for Interrogating Host Biology During Infection
Ramanathan R, Hatzios S. Activity‐based Tools for Interrogating Host Biology During Infection. Israel Journal Of Chemistry 2023, 63 PMID: 37744997, PMCID: PMC10512441, DOI: 10.1002/ijch.202200095.Peer-Reviewed Original ResearchCitationsAltmetricConceptsActivity-based protein profilingPost-translational modificationsHost post-translational modificationsHost-microbe interactionsHost biologyCells senseCell signalingMicrobial mechanismsEnzyme functionProtein profilingProtein structureSide-chain reactivityChemical probesInfected cellsHost-directed therapiesPotential targetRapid modulationHost responseSignalingBiologyInfectionEnzymeProfilingPathwayPathogens
2022
A microbial transporter of the dietary antioxidant ergothioneine
Dumitrescu D, Gordon E, Kovalyova Y, Seminara A, Duncan-Lowey B, Forster E, Zhou W, Booth C, Shen A, Kranzusch P, Hatzios S. A microbial transporter of the dietary antioxidant ergothioneine. Cell 2022, 185: 4526-4540.e18. PMID: 36347253, PMCID: PMC9691600, DOI: 10.1016/j.cell.2022.10.008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInter-kingdom competitionHost-associated microbesIntracellular redox homeostasisGastric pathogen Helicobacter pyloriPathogen Helicobacter pyloriRedox regulationSmall molecule antioxidantsRedox homeostasisBiosynthetic pathwayColonization advantageUnappreciated mechanismLMW thiolsHost environmentHuman faecal bacteriaWeight thiolsCertain microorganismsAntioxidant ergothioneineGastrointestinal microbesMetabolite trimethylamine N-oxideMicrobesMillimolar levelsHuman tissuesErgothioneineTrimethylamine N-oxideFecal bacteriaA propeptide-based biosensor for the selective detection of Vibrio cholerae using an environment-sensitive fluorophore
DeColli AA, Koolik IM, Seminara AB, Hatzios SK. A propeptide-based biosensor for the selective detection of Vibrio cholerae using an environment-sensitive fluorophore. Cell Chemical Biology 2022, 29: 1505-1516.e7. PMID: 36270233, DOI: 10.1016/j.chembiol.2022.09.003.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
Academic Achievements & Community Involvement
Honors
honor Sloan Research Fellowship in Chemistry
09/15/2024National AwardAlfred P. Sloan Foundationhonor Inaugural Early Career Board Member
01/01/2024National AwardACS Infectious Diseaseshonor Young Investigator Award
08/13/2023National AwardACS Infectious Diseases and American Chemical Society Division of Biological Chemistryhonor Conquer Cancer Now Award
10/01/2020National AwardThe Concern FoundationDetailsUnited Stateshonor Yale Cancer Center Pilot Award
09/01/2020Yale School of Medicine AwardYale Cancer Center
News
News
- January 03, 2023Source: SciTechDaily
Shocking Yale Research: Common Nutrient Found To Aid Survival of Cancer-Causing Bacterium
- November 07, 2022Source: Yale West Campus
Role of Nutrient May Reveal Dietary Target in Fight Against Microbial Infections
- March 24, 2022
Yale Scientists Deploy Chemical Tools to Detect Cancer-causing Proteins
Get In Touch
Contacts
Academic Office Number
Administrative Support
Locations
Microbial Sciences Institute, ABC 207
Lab
West Campus Advanced Biosciences Center
840 West Campus Drive
West Haven, CT 06516