2023
Emerging roles of low-molecular-weight thiols at the host–microbe interface
Dumitrescu D, Hatzios S. Emerging roles of low-molecular-weight thiols at the host–microbe interface. Current Opinion In Chemical Biology 2023, 75: 102322. PMID: 37201290, PMCID: PMC10524283, DOI: 10.1016/j.cbpa.2023.102322.Peer-Reviewed Original ResearchConceptsHost-microbe interfaceLMW thiolsWeight thiolsCellular redox homeostasisRedox-active metabolitesCellular physiologyVirulence regulationRedox homeostasisHost physiologyAbundant classMicrobial metabolismHost cellsIntercellular interactionsForms of lifeInfected cellsSmall moleculesPhysiologyCellsComputational approachThiolsHomeostasisRegulationRoleMetabolismDiscovery
2022
A microbial transporter of the dietary antioxidant ergothioneine
Dumitrescu D, Gordon E, Kovalyova Y, Seminara A, Duncan-Lowey B, Forster E, Zhou W, Booth C, Shen A, Kranzusch P, Hatzios S. A microbial transporter of the dietary antioxidant ergothioneine. Cell 2022, 185: 4526-4540.e18. PMID: 36347253, PMCID: PMC9691600, DOI: 10.1016/j.cell.2022.10.008.Peer-Reviewed Original ResearchConceptsInter-kingdom competitionHost-associated microbesIntracellular redox homeostasisGastric pathogen Helicobacter pyloriPathogen Helicobacter pyloriRedox regulationSmall molecule antioxidantsRedox homeostasisBiosynthetic pathwayColonization advantageUnappreciated mechanismLMW thiolsHost environmentHuman faecal bacteriaWeight thiolsCertain microorganismsAntioxidant ergothioneineGastrointestinal microbesMetabolite trimethylamine N-oxideMicrobesMillimolar levelsHuman tissuesErgothioneineTrimethylamine N-oxideFecal bacteria