Nii Addy, PhD
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Contact/Administration
About
Contact/Administration
Contact Info
Addy Lab
300 George Street, Suite 901
New Haven, CT 06511
United States
Titles
Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology
Director of Faculty Development and Collaborative Excellence, YSM Office of Collaborative Excellence
Appointments
Contact Info
Addy Lab
300 George Street, Suite 901
New Haven, CT 06511
United States
Titles
Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology
Director of Faculty Development and Collaborative Excellence, YSM Office of Collaborative Excellence
Appointments
Contact Info
Addy Lab
300 George Street, Suite 901
New Haven, CT 06511
United States
About
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Titles
Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology
Director of Faculty Development and Collaborative Excellence, YSM Office of Collaborative Excellence
Biography
Nii Addy is the Albert E. Kent Associate Professor of Psychiatry and Associate Professor of Cellular and Molecular Physiology and the Director of Faculty Development and Collaborative Excellence. He is also Director of the Faculty Mentoring Program for the Minority Organization for Retention and Expansion (MORE) and former co-chair of the Career Development Subcommittee of the ARCH Task Force in the Yale Department of Psychiatry. He contributes to graduate student and postdoctoral training and to mentorship and sponsorship initiatives through his efforts on campus and in scientific societies.
He received his B.S. in Biology from Duke University and his Ph.D. in Neuroscience from Yale University. Dr. Addy directs a federally funded research program investigating cholinergic, dopaminergic and L-type calcium channel mechanisms mediating substance use and mood disorders. Dr. Addy’s team also studies the ability of tobacco product flavor additives to alter nicotine use behavior and addiction. He serves on the journal editorial board of Neuropsychopharmacology, Biological Psychiatry, and Neuropharmacology, and he previously served as a grant reviewer for the Neurobiology of Motivated Behavior (NMB) Study Section of the National Institutes of Health's Center for Scientific Review (CSR).
In addition to his campus work, Dr. Addy hosts the Addy Hour podcast, discussing topics at the intersection of neuroscience, mental health, faith, and culture. Episodes include dynamic conversations based on the lived experience and professional expertise of his guests - which include community leaders, clinicians and mental health experts, scientists, professional athletes and entertainers, faith leaders, and mental health advocates. As the creator and host of town hall community events, Dr. Addy has also built unique partnerships to encourage and equip audiences to embrace the use of holistic, integrated tools to address mental health challenges. He has collaborated with Lecrae (Grammy Award-winning artist and NY Times Best Seller), Doug Middleton (Jacksonville Jaguars/ Dream the Impossible Initiative), Allan Houston (former NBA All-Star, NY Knicks/ FISLL Project), the National Alliance on Mental Illness (NAMI), the Veritas Forum, the Anxiety and Depression Association of America (ADAA), the Association for Behavioral and Cognitive Therapies (ABCT), the Yale University Chaplain's Office, Yale Well, the Salvation Army, Every Nation Church NYC, the American Bible Society and others. His research and community work have been featured by National Public Radio (NPR), Newsday, the National Football League Players Association (NFLPA), The Source Magazine, Chuck Norris, BoldTV, Legitimate Matters, and Relevant Magazine. He has presented scientific lectures at universities throughout the United States and Europe, and he serves on the Board of Trustees for The Carver Project, aimed at empowering and connecting individuals across university, church and society.
Appointments
Psychiatry
Associate Professor on TermPrimaryCellular & Molecular Physiology
Associate Professor on TermSecondary
Other Departments & Organizations
- Abraham Ribicoff Research Facilities
- Addy Lab
- Cellular & Molecular Physiology
- Connecticut Mental Health Center
- Division of Molecular Psychiatry
- Interdepartmental Neuroscience Program
- Molecular Medicine, Pharmacology, and Physiology
- MORE
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Psychiatry
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Tobacco Center of Regulatory Science
- Yale Ventures
- YSM Office of Collaborative Excellence
Education & Training
- PhD
- Yale University (2007)
- BS
- Duke University (2000)
Research
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Overview
Medical Research Interests
ORCID
0000-0002-9321-6067- View Lab Website
Addy Lab at Yale
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Deniz Bagdas, DVM, PhD
Marina Picciotto, PhD
Ayana Jordan, MD, PhD
John Krystal, MD
Yusuf Ransome, MPH, DrPH
Signal Transduction
Substance-Related Disorders
Electrochemistry
Publications
Featured Publications
Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors
Bagdas D, Sedaille J, Khan M, Okpala N, Addy N. Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors. Nicotine & Tobacco Research 2025, 28: 242-250. PMID: 40097606, PMCID: PMC12824949, DOI: 10.1093/ntr/ntaf037.Peer-Reviewed Original ResearchCitationsAltmetricTargeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders
Nunes E, Addy N, Conn P, Foster D. Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders. The Annual Review Of Pharmacology And Toxicology 2023, 64: 277-289. PMID: 37552895, PMCID: PMC10841102, DOI: 10.1146/annurev-pharmtox-051921-023858.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricVentral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner
Nunes E, Kebede N, Haight J, Foster D, Lindsley C, Conn P, Addy N. Ventral Tegmental Area M5 Muscarinic Receptors Mediate Effort-Choice Responding and Nucleus Accumbens Dopamine in a Sex-Specific Manner . Journal Of Pharmacology And Experimental Therapeutics 2023, 385: 146-156. PMID: 36828630, PMCID: PMC10108441, DOI: 10.1124/jpet.122.001438.Peer-Reviewed Original ResearchCitationsAltmetricAnimal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence
Bagdas D, Kebede N, Zepei AM, Harris L, Minanov K, Picciotto MR, Addy NA. Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence. Current Neuropharmacology 2022, 20: 2175-2201. PMID: 35611777, PMCID: PMC9886843, DOI: 10.2174/1570159x20666220524120231.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsThe L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway
Addy NA, Nunes EJ, Hughley SM, Small KM, Baracz SJ, Haight JL, Rajadhyaksha AM. The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway. Neuropsychopharmacology 2018, 43: 2361-2372. PMID: 29773910, PMCID: PMC6180103, DOI: 10.1038/s41386-018-0080-2.Peer-Reviewed Original ResearchCitationsAltmetricVentral tegmental area muscarinic receptors modulate depression and anxiety-related behaviors in rats
Small KM, Nunes E, Hughley S, Addy NA. Ventral tegmental area muscarinic receptors modulate depression and anxiety-related behaviors in rats. Neuroscience Letters 2016, 616: 80-85. PMID: 26828299, PMCID: PMC4798862, DOI: 10.1016/j.neulet.2016.01.057.Peer-Reviewed Original ResearchCitationsEnhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens
Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM. Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Molecular Psychiatry 2017, 22: 1735-1745. PMID: 28194001, PMCID: PMC5555837, DOI: 10.1038/mp.2017.9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAffectAnimalsCalcium Channels, L-TypeCocaineCocaine-Related DisordersConditioning, PsychologicalDepressionDisease Models, AnimalDopamine Uptake InhibitorsGenetic Association StudiesHumansMaleMice, Inbred C57BLMice, TransgenicMotor ActivityNucleus AccumbensPost-Synaptic DensityReceptors, AMPASocial BehaviorVentral Tegmental AreaEvaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling
Wickham RJ, Nunes EJ, Hughley S, Silva P, Walton SN, Park J, Addy NA. Evaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling. Neuropharmacology 2017, 128: 33-42. PMID: 28943284, PMCID: PMC5714675, DOI: 10.1016/j.neuropharm.2017.09.029.Peer-Reviewed Original ResearchCitationsAltmetricChronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats
Bagdas D, Harris L, Addy N. Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats. Neuroscience Letters 2022, 793: 137008. PMID: 36476758, PMCID: PMC9948648, DOI: 10.1016/j.neulet.2022.137008.Peer-Reviewed Original ResearchCitationsAltmetricSupporting mentees through inclusive mentorship
Addy T, Addy N, Hendrickson B, Mitchell K. Supporting mentees through inclusive mentorship. New Directions For Teaching And Learning 2023, 2023: 11-19. DOI: 10.1002/tl.20554.Peer-Reviewed Original ResearchCitations
News
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News
- October 12, 2026
Addy Honored with East Grand Rapids School District's Distinguished Alumni Award
- August 31, 2026
Yale Neuroscience Summer Scholars Program Ends with Student Presentations
- July 17, 2026
Addy to be Honored by East Grand Rapids Schools Foundation with Distinguished Alumni Award
- April 09, 2026
Research by Bagdas, Addy Named Best Paper in Basic Science by Society for Research on Nicotine and Tobacco
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Addy Lab
300 George Street, Suite 901
New Haven, CT 06511
United States