Maudry Laurent-Rolle, MD, PhD, BS
Assistant ProfessorCards
About
Titles
Assistant Professor
Biography
Dr. Maudry Laurent-Rolle received her B.S. from Long Island University, Brooklyn Campus in Biology in 2001. She then obtained her MD and PhD from Icahn School of Medicine at Mount Sinai. Her dissertation research was funded by an NIH pre-doctoral fellowship, which allowed her to examine the molecular mechanisms by which flaviviruses inhibit host innate immune responses. She completed residency training in Internal Medicine at Albert Einstein/Montefiore Medical Center in 2016 then joined the Infectious Diseases Fellowship program here at Yale University. Her research focus is on vaccine design and development of antivirals. She is originally from the beautiful Caribbean island of Dominica, known for its many rivers, tropical rainforests, and natural hot springs.
Appointments
Infectious Diseases
Assistant ProfessorPrimaryMicrobial Pathogenesis
Assistant ProfessorSecondary
Other Departments & Organizations
Education & Training
- Research Fellow in Infectious Diseases
- Section of Infectious Diseases (2020)
- Fellow
- Yale University (2019)
- Resident
- Albert Einstein/Montefiore Medical Center (2016)
- MD
- Icahn School of Medicine at Mount Sinai (2013)
- PhD
- Icahn School of Medicine at Mount Sinai, Microbiology (2011)
- Non Degree Program
- Icahn School of Medicine at Mount Sinai, Postbaccalaureate Research Education Program (2004)
- BS
- Long Island University, Biology (2001)
Research
Overview
I spent the last 16 years studying the molecular mechanisms utilized by pathogenic viruses, specifically flaviviruses, to antagonize host immune responses. During my training in the Post Baccalaureate Research Education Program (PREP) at the Icahn School of Medicine at Mount Sinai I helped developed a reporter assay system that was used to screen dengue virus-encoded proteins’ ability to inhibit the type I interferon response. During my graduate school years, I was awarded a competitive NIH F31 grant based on my doctoral studies focused on understanding how West Nile virus (WNV), dengue virus (DENV) and yellow fever virus (YFV) inhibit the host innate immune response. I characterized the molecular mechanisms by which these viruses use the nonstructural protein 5 (NS5) to inhibit interferon signaling albeit through distinct mechanisms. My thesis project as well as several collaborations resulted in a provisional vaccine patent, a book chapter, and several articles that have been published in high impact journals.
After completing my Internal Medicine residency, I joined the Infectious Diseases Fellowship program here at Yale University. After the first intensive clinical year, I transitioned to basic science research where I focus on characterizing the molecular mechanism(s) by which the antiviral protein, CMPK2 restricts viral replication. The results of this work may lead to the development of new drug targets. In addition to my research, I am also a lecturer in the department of Molecular Biophysics and Biochemistry here at Yale School of Medicine. My clinical experiences and research training in virology as well as biochemical and immunological methods place me in a position to answer the fundamental questions that will contribute to my overall long term goal of vaccine design and development of antivirals.
Academic Achievements & Community Involvement
Teaching & Mentoring
News
News
- April 02, 2024
Yale Department of Internal Medicine Promotions and Appointments (April 2024)
- July 25, 2023Source: Stamford Advocate
Yale researchers are working on a whole new type of vaccine, targeting the insects that carry pathogens
- July 06, 2023
4 Things to Know About Zika Virus
- June 28, 2023
“Coolest Protein” Restricts Zika Virus Replication