Karen Anderson, PhD
Professor of Pharmacology and of Molecular Biophysics and BiochemistryCards
About
Research
Overview
Our research is directed toward understanding molecular mechanism of clinically important antimicrobial, anticancer, and antiviral molecular targets with the ultimate goal of developing more effective therapies. Key enzyme targets for the development of therapeutics include: KDO8P synthase (an important target for new antibacterials) and a bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) enzyme from parasites (a target for new antiparasitic drugs).
Also ongoing are studies to understanding the molecular mechanisms of normal and aberrant protein signaling and the effects of selectively guided anticancer drugs such as Iressa and Gleevec. Important molecular targets include EGFR, HER-2, PDGFRb, and c-kit receptor tyrosine kinases. Another area of focus involves investigating the mechanisms of HIV reverse transcriptase as well as drug resistance and toxicity that may ultimately aid in the design of better therapeutic agents for the treatment of AIDS.
Also ongoing are studies to understanding the molecular mechanisms of normal and aberrant protein signaling and the effects of selectively guided anticancer drugs such as Iressa and Gleevec. Important molecular targets include EGFR, HER-2, PDGFRb, and c-kit receptor tyrosine kinases. Another area of focus involves investigating the mechanisms of HIV reverse transcriptase as well as drug resistance and toxicity that may ultimately aid in the design of better therapeutic agents for the treatment of AIDS.
Medical Research Interests
Anti-Retroviral Agents; HIV Reverse Transcriptase; Molecular Biology; Multifunctional Enzymes; Pharmacology
Academic Achievements & Community Involvement
News
News
- April 23, 2024
A Better COVID Treatment for the Immunocompromised?
- April 15, 2024
Treatments Found in Translational Science
- July 31, 2023
Researchers Develop a New Way to Classify HPV-Associated Head and Neck Cancers
- July 13, 2021Source: News Wise
Scientists Repurpose Cancer and Seizure Medications to Aid in the Fight against COVID-19
Get In Touch
Contacts
Academic Office Number
Lab Number
Office Fax Number
Mailing Address
Pharmacology
PO Box 208066, 333 Cedar Street
New Haven, CT 06520-8066
United States
Administrative Support
Locations
Department of Pharmacology
Academic Office
Sterling Hall of Medicine, B-Wing
333 Cedar Street, Ste B350b
New Haven, CT 06510
Events
May 20258Thursday
- Yale Only