Elias Lolis, PhD
Professor of PharmacologyCards
About
Research
Overview
We are generally interested in understanding the biology, structure, mechanism of action, and pharmacology (inhibition) of proteins in physiology and pathophysiology. Our studies are multidisciplinary and include structural biology (X-ray crystallography or NMR), molecular dynamics, high throughput screening (HPTS) and/or inhibitor design, mutational analysis, the use of strains of yeast expressing functional chemokine receptors for signaling and HTPS, and Crispr/Cas mice as a model system for models of disease.
Specific projects include:
1. Chemokine-chemokine receptor (GPCR) structures
2. High throughput screening to identify small molecule agonists and antagonists of chemokines and their GPCR receptors
3. Yeast genetics to identify and quantitate chemokine-chemokine receptor interactions
4. Mechanism of receptor activation for macrophage migration inhibitory factor
5. Identification of the substrate of MIF and structure of MIF-ligand complexes
6. Study of antagonists receptors in disease models
7. Co-crystal structures of other protein-inhibitors complexes
Medical Research Interests
News
News
Get In Touch
Contacts
Pharmacology
PO Box 208066, 333 Cedar Street
New Haven, CT 06520-8066
United States