2021
Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy
Han J, Zhao Y, Shirai K, Molodtsov A, Kolling FW, Fisher JL, Zhang P, Yan S, Searles TG, Bader JM, Gui J, Cheng C, Ernstoff MS, Turk MJ, Angeles CV. Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy. Nature Cancer 2021, 2: 300-311. PMID: 34179824, PMCID: PMC8223731, DOI: 10.1038/s43018-021-00180-1.Peer-Reviewed Original ResearchConceptsT cell responsesMemory T cellsT cellsEffector memory T cellsResident memory T cellsMetastatic melanoma survivorsT cells persistStrong prognostic valueT cell receptorDurable responsesMemory CD8Melanoma patientsCancer survivorsPrognostic valueCancer immunotherapyMelanoma survivorsCells persistClonal repertoireSingle-cell RNA sequencingImmunotherapyTumorsExceptional responsePatient's skinClonotypesBlood
2018
Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses.
Woodham AW, Cheloha RW, Ling J, Rashidian M, Kolifrath SC, Mesyngier M, Duarte JN, Bader JM, Skeate JG, Da Silva DM, Kast WM, Ploegh HL. Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses. Cancer Immunology Research 2018, 6: 870-880. PMID: 29792298, PMCID: PMC6030498, DOI: 10.1158/2326-6066.CIR-17-0661.Peer-Reviewed Original Research
2016
Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs.
Duarte JN, Cragnolini JJ, Swee LK, Bilate AM, Bader J, Ingram JR, Rashidfarrokhi A, Fang T, Schiepers A, Hanke L, Ploegh HL. Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs. Journal Of Immunology (Baltimore, Md. : 1950) 2016, 197: 4838-4847. PMID: 27821668, PMCID: PMC5806123, DOI: 10.4049/jimmunol.1600692.Peer-Reviewed Original Research
2015
Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.
Dorr C, Janik C, Weg M, Been RA, Bader J, Kang R, Ng B, Foran L, Landman SR, O'Sullivan MG, Steinbach M, Sarver AL, Silverstein KA, Largaespada DA, Starr TK. Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. Molecular Cancer Research : MCR 2015, 13: 1238-47. PMID: 25995385, PMCID: PMC4543426, DOI: 10.1158/1541-7786.MCR-14-0674-T.Peer-Reviewed Original Research