Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy
Han J, Zhao Y, Shirai K, Molodtsov A, Kolling FW, Fisher JL, Zhang P, Yan S, Searles TG, Bader JM, Gui J, Cheng C, Ernstoff MS, Turk MJ, Angeles CV. Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy. Nature Cancer 2021, 2: 300-311. PMID: 34179824, PMCID: PMC8223731, DOI: 10.1038/s43018-021-00180-1.Peer-Reviewed Original ResearchConceptsT cell responsesMemory T cellsT cellsEffector memory T cellsResident memory T cellsMetastatic melanoma survivorsT cells persistStrong prognostic valueT cell receptorDurable responsesMemory CD8Melanoma patientsCancer survivorsPrognostic valueCancer immunotherapyMelanoma survivorsCells persistClonal repertoireSingle-cell RNA sequencingImmunotherapyTumorsExceptional responsePatient's skinClonotypesBlood