2023
Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing
Chaudhary S, Zhang S, Zhornitsky S, Chen Y, Chao H, Li C. Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing. NeuroImage 2023, 276: 120207. PMID: 37263454, PMCID: PMC10330646, DOI: 10.1016/j.neuroimage.2023.120207.Peer-Reviewed Original ResearchConceptsFaster reaction timesNegative emotionsAge-related declineEmotional stimuliTrait anxietyAge-related reductionReaction timeEmotion regulation literatureSalient emotional stimuliPositive emotional stimuliFacial emotion processingPrefrontal cortical responsesRostral anterior cingulate cortexWhole-brain regressionAnterior cingulate activityDefault mode networkAnterior cingulate cortexEmotion regulationNeural evidenceEmotion processingDorsolateral PFCStimulus registrationDiminished anxietyPsychophysiological interactionEmotional circuits
2022
Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Cerebral Volumetric Correlates of Apathy in Alzheimer’s Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort. Journal Of Alzheimer's Disease 2022, 85: 1251-1265. PMID: 34924392, PMCID: PMC9215906, DOI: 10.3233/jad-215316.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseInferior frontal gyrusIndependent cohortEmotional scoresHealthy controlsCognitive impairmentVolumetric correlatesMini-Mental State Examination scoreAD/mild cognitive impairmentNeuroanatomical correlatesState Examination scoreApathy Evaluation ScaleGray matter volumeVoxel-based morphometryRight inferior frontal gyrusLabel-based reviewMild cognitive impairmentNormal older adultsCortical atrophyHigh morbidityBasal gangliaRight putamenMatter volumeAnterior cingulateReduced quality
2020
Altered multimodal magnetic resonance parameters of basal nucleus of Meynert in Alzheimer’s disease
Zheng W, Li H, Cui B, Liang P, Wu Y, Han X, Li C, Li K, Wang Z. Altered multimodal magnetic resonance parameters of basal nucleus of Meynert in Alzheimer’s disease. Annals Of Clinical And Translational Neurology 2020, 7: 1919-1929. PMID: 32888399, PMCID: PMC7545587, DOI: 10.1002/acn3.51176.Peer-Reviewed Original ResearchConceptsGray matter volumeHealthy controlsFunctional connectivityBasal nucleusResting-state functional connectivityDaily living statusLower gray matter volumeArterial spin labeling imagingWhole-brain functional connectivityRegional blood flowPostmortem human brainVoxel-based morphometryCholinergic dysfunctionHigher rCBFRight insulaDynamic network connectivity predicts subjective cognitive decline: the Sino-Longitudinal Cognitive impairment and dementia study
Dong G, Yang L, Li CR, Wang X, Zhang Y, Du W, Han Y, Tang X. Dynamic network connectivity predicts subjective cognitive decline: the Sino-Longitudinal Cognitive impairment and dementia study. Brain Imaging And Behavior 2020, 14: 2692-2707. PMID: 32361946, PMCID: PMC7606422, DOI: 10.1007/s11682-019-00220-6.Peer-Reviewed Original Research
2019
The effects of age on reward magnitude processing in the monetary incentive delay task
Dhingra I, Zhang S, Zhornitsky S, Le T, Wang W, Chao HH, Levy I, Li CR. The effects of age on reward magnitude processing in the monetary incentive delay task. NeuroImage 2019, 207: 116368. PMID: 31743790, PMCID: PMC7463276, DOI: 10.1016/j.neuroimage.2019.116368.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskSupplementary motor areaMagnitude of rewardAge-related differencesDelay taskRT differencesRegional activationAge effectsEffect of ageReaction time differencesRight anterior insulaMiddle frontal gyrusReward-directed behaviorExplicit cuesMagnitude processingBrain activationRight caudate headAnterior insulaFrontal gyrusReward magnitudeLarge rewardPrimary motor cortexCerebral processesParahippocampal gyrusThe effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study
Wang W, Zhornitsky S, Chao HH, Levy I, Joormann J, Li CR. The effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study. Behavioural Brain Research 2019, 378: 112301. PMID: 31644928, PMCID: PMC6893150, DOI: 10.1016/j.bbr.2019.112301.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsSocial interactionSocial anxietyCyberball taskNeural processesOccipital cortexBall tossPregenual anterior cingulate cortexAnterior cingulate cortexSex differencesSocial exclusionAnxiety Scale scoresBehavioral performanceOrbitofrontal cortexCingulate cortexSubjective reportsBehavioral burdenEffect of ageObserved sex differencesYoung adultsCerebral responsesAge-related diminutionGame sessionsAnxietyCortex
2018
Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
Cheng H, Chen H, Lv Y, Chen Z, Li C. Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer. Cancer Medicine 2018, 7: 5315-5321. PMID: 30259694, PMCID: PMC6198199, DOI: 10.1002/cam4.1784.Peer-Reviewed Original ResearchConceptsDigit span testVerbal fluency testProspective memory impairmentMini-Mental State ExaminationTime-based prospective memory taskMemory impairmentProspective memory taskCognitive neuropsychological testsWhole brain radiotherapyMetastatic brain cancerMemory taskSpan testFluency testNeuropsychological testsBrain cancerState ExaminationBrain metastasesBrain radiotherapyCancer patientsImpairmentNonsignificant decreasePatientsTBPMRadiotherapyTaskDecreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement
Yu T, Li Y, Fan F, Cao H, Luo X, Tan S, Yang F, Zhang X, Shugart YY, Hong LE, Li CR, Tan Y. Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement. Scientific Reports 2018, 8: 12884. PMID: 30150749, PMCID: PMC6110787, DOI: 10.1038/s41598-018-31186-y.Peer-Reviewed Original ResearchConceptsGray matter volumeAbnormal Involuntary Movement ScaleTardive dyskinesiaMatter volumeTD severityAntipsychotic medication treatmentCerebral morphological changesAbnormal involuntary movementsBrain structural magnetic resonance imagesPsychopathological symptomsNegative Syndrome ScaleNon-TD groupVoxel-based morphometryMedication treatmentHealthy controlsGMV changesMotor disordersAIMS scoresInvoluntary movementsMovement ScaleStructural magnetic resonance imagesTemporal cortexSchizophrenia patientsLingual gyrusSyndrome ScaleStructural and functional cerebral bases of diminished inhibitory control during healthy aging
Hu S, Ide JS, Chao HH, Castagna B, Fischer KA, Zhang S, Li C. Structural and functional cerebral bases of diminished inhibitory control during healthy aging. Human Brain Mapping 2018, 39: 5085-5096. PMID: 30113124, PMCID: PMC6287913, DOI: 10.1002/hbm.24347.Peer-Reviewed Original ResearchConceptsProlonged stop signal reaction timeStop-signal reaction timeAge-related reductionInhibitory controlFunctional changesPrefrontal cortexAge-related diminutionSignal taskRight dorsolateral prefrontal cortexSame brain regionsFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexInferior parietal cortexResponse inhibitionDorsolateral prefrontal cortexInferior frontal cortexDiminished inhibitory controlCerebral changesStructure-function associationsSignal reaction timeCaudate headAge-related differencesStop-signal taskFrontal cortexLevodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease
Manza P, Schwartz G, Masson M, Kann S, Volkow ND, Li CR, Leung HC. Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease. Neurobiology Of Aging 2018, 66: 12-22. PMID: 29501966, PMCID: PMC6436810, DOI: 10.1016/j.neurobiolaging.2018.02.003.Peer-Reviewed Original ResearchConceptsEarly-stage Parkinson's diseaseParkinson's diseaseDopaminergic medicationAdvanced Parkinson's diseaseStriatal activationResponse inhibitionRole of dopaminergicAge-matched controlsFunctional magnetic resonance imagingMagnetic resonance imagingExecutive functionLevodopa monotherapyMultiple medicationsMotor symptomsSignificant group differencesPD groupStop-signal taskAdvanced stageLevodopaResonance imagingMedicationsFunctional connectivityCritical executive functionMotor inhibitionPatientsResting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers
Hu S, Ide JS, Chao HH, Zhornitsky S, Fischer KA, Wang W, Zhang S, Li CR. Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers. Drug And Alcohol Dependence 2018, 185: 173-180. PMID: 29454928, PMCID: PMC5889735, DOI: 10.1016/j.drugalcdep.2017.11.026.Peer-Reviewed Original ResearchConceptsState functional connectivityDorsal anterior cingulate cortexAlcohol misuseAlcohol drinkersFunctional connectivityInvolvement scoreProblem drinkingSubstance useWhole-brain rsFCComorbid substance useAmygdala-prefrontal cortical circuitAnterior cingulate cortexStatistical parametric mappingPotential sex differencesPrefrontal cortical structuresAmygdala connectivityCortical functionCortical circuitsCingulate cortexAmygdalaCortical structuresParametric mappingSex differencesDrinkingDrinkers
2015
Resting‐state functional connectivity of the striatum in early‐stage Parkinson's disease: Cognitive decline and motor symptomatology
Manza P, Zhang S, Li C, Leung H. Resting‐state functional connectivity of the striatum in early‐stage Parkinson's disease: Cognitive decline and motor symptomatology. Human Brain Mapping 2015, 37: 648-662. PMID: 26566885, PMCID: PMC4843498, DOI: 10.1002/hbm.23056.Peer-Reviewed Original ResearchConceptsParkinson's diseaseFunctional connectivity patternsMotor deficitsFunctional connectivityRostral anterior cingulate cortexState functional connectivity patternsAnterior cingulate cortexConnectivity patternsAnterior putamenMotor symptomsSubstantia nigraDopaminergic functionHealthy controlsMotor functionDorsal caudateStriatal connectivityStriatal subregionsSymptomatic individualsMotor impairmentCingulate cortexCognitive declineNeurodegenerative disordersCognitive functionDiseaseEarly stage individualsIndependent component analysis of functional networks for response inhibition: Inter‐subject variation in stop signal reaction time
Zhang S, Tsai S, Hu S, Xu J, Chao HH, Calhoun VD, Li C. Independent component analysis of functional networks for response inhibition: Inter‐subject variation in stop signal reaction time. Human Brain Mapping 2015, 36: 3289-3302. PMID: 26089095, PMCID: PMC4545723, DOI: 10.1002/hbm.22819.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskCognitive controlSignal reaction timeResponse inhibitionStop successBeta weightsReaction timeCritical executive functionFunctional networksIndependent component analysisExecutive functionError trialsSignal taskComponent processesMotor preparationBrain networksBehavioral validityMotor regionsRace modelLinear modelingGeneral linear modelingLarge sampleIndependent componentsFMRIRevising the American dream: how Asian immigrants adjust after an HIV diagnosis
Chen WT, Guthrie B, Shiu CS, Wang L, Weng Z, Li CS, Lee TS, Kamitani E, Fukuda Y, Luu BV. Revising the American dream: how Asian immigrants adjust after an HIV diagnosis. Journal Of Advanced Nursing 2015, 71: 1914-1925. PMID: 25740206, PMCID: PMC4503482, DOI: 10.1111/jan.12645.Peer-Reviewed Original Research
2013
Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder
Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global Resting-State Functional Magnetic Resonance Imaging Analysis Identifies Frontal Cortex, Striatal, and Cerebellar Dysconnectivity in Obsessive-Compulsive Disorder. Biological Psychiatry 2013, 75: 595-605. PMID: 24314349, PMCID: PMC3969771, DOI: 10.1016/j.biopsych.2013.10.021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPrefrontal cortexResting-state functional connectivity dataStriatum/nucleus accumbensVentral striatum/nucleus accumbensResting-state functional connectivity studiesVentral anterior cingulate cortexCortico-striatal circuitsMagnetic Resonance Imaging AnalysisAnterior cingulate cortexFunctional connectivity studiesBasal gangliaControl subjectsFunctional connectivity dataAnterior thalamusRight putamenFrontal cortexNucleus accumbensDorsal striatumCerebellar cortexAbnormal neural connectivityCerebellar dysconnectivityCingulate cortexWhole brainFunctional magnetic resonance imaging (fMRI) analysisEffects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study
Chao HH, Hu S, Ide JS, Uchio E, Zhang S, Rose M, Concato J, Li CS. Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study. PLOS ONE 2013, 8: e72032. PMID: 23977199, PMCID: PMC3747074, DOI: 10.1371/journal.pone.0072032.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsGray matter volumeMagnetic resonance imagingPrimary motor cortexCancer patientsVoxel-based morphometryMatter volumeMotor cortexProstate cancerEffects of ADTLow-risk prostate cancerCerebral gray matter volumeStatistical Parametric Mapping 8Utility of brainControl participantsHigh-resolution magnetic resonance imagingPotential side effectsQuality of lifeResolution magnetic resonance imagingSame time pointsFunctional magnetic resonance imagingHigh-resolution T1Prefrontal cortical activationDorsolateral prefrontal cortexChanges in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control
Hu S, Chao H, Zhang S, Ide JS, Li CS. Changes in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control. Brain Structure And Function 2013, 219: 983-994. PMID: 23553547, PMCID: PMC3760988, DOI: 10.1007/s00429-013-0548-0.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexInferior parietal lobuleSupplementary motor areaFrontal regionsInhibitory controlCingulate cortexStop-signal reaction timeBilateral dorsal lateral prefrontal cortexGM volumeCognitive performance decreasesRight inferior parietal lobuleLow-frequency fluctuationsLateral prefrontal cortexSignal reaction timePosterior cingulate cortexAnterior cingulate cortexBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFamily-wise errorGray matter volumeRecent alcohol useCognitive challengesParietal lobuleSpontaneous neural activityVoxel-based morphometry
2012
Rare ADH Variant Constellations are Specific for Alcohol Dependence
Zuo L, Zhang H, Malison RT, Li CS, Zhang XY, Wang F, Lu L, Lu L, Wang X, Krystal JH, Zhang F, Deng HW, Luo X. Rare ADH Variant Constellations are Specific for Alcohol Dependence. Alcohol And Alcoholism 2012, 48: 9-14. PMID: 23019235, PMCID: PMC3523382, DOI: 10.1093/alcalc/ags104.Peer-Reviewed Original ResearchEffects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis
Chao HH, Uchio E, Zhang S, Hu S, Bednarski SR, Luo X, Rose M, Concato J, Li CS. Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis. BMC Cancer 2012, 12: 371. PMID: 22925152, PMCID: PMC3502584, DOI: 10.1186/1471-2407-12-371.Peer-Reviewed Original ResearchMeSH KeywordsAgedAndrogen AntagonistsAnilidesAntineoplastic Agents, HormonalBrainCognitionCohort StudiesGoserelinHumansMagnetic Resonance ImagingMaleMemoryMiddle AgedNeuropsychological TestsNitrilesProspective StudiesProstatic NeoplasmsPsychomotor PerformanceQuality of LifeSurveys and QuestionnairesTosyl CompoundsTreatment OutcomeConceptsAndrogen deprivation therapyFunctional magnetic resonance imagingProspective observational cohort analysisObservational cohort analysisN-back taskStop-signal taskCognitive controlProstate cancerBrain activationCohort analysisLow-risk prostate cancerNon-metastatic prostate cancerVeterans Affairs Medical CenterLong-term clinical implicationsBrain connectivityProstate cancer patientsPrefrontal cortical activationQuality of lifeFunctional brain connectivityMagnetic resonance imagingMedial prefrontal cortexParticular clinical concernDeprivation therapyADT useAndrogen deprivation