2024
Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behaviorRelationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalitiesSex differences in the effects of individual anxiety state on regional responses to negative emotional scenes
Chaudhary S, Wong H, Chen Y, Zhang S, Li C. Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes. Biology Of Sex Differences 2024, 15: 15. PMID: 38351045, PMCID: PMC10863151, DOI: 10.1186/s13293-024-00591-6.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexState-Trait Anxiety InventoryFunctional magnetic resonance imagingState-Trait Anxiety Inventory scoresSuperior frontal gyrusGeneralized psychophysiological interactionEmotional processingFrontal gyrusLingual gyrusMedial prefrontal cortex connectivityMedial prefrontal cortex activationSex differencesRight inferior frontal gyrusResponse to negative emotionsRight superior frontal gyrusFunctional magnetic resonance imaging dataReaction timeImpact emotional processingNegative emotion processingInferior frontal gyrusLeft parahippocampal gyrusNegative emotional scenesMarkers of anxietyRepeated-measures analysis of covarianceLevels of anxiety
2023
Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanismRelationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential ageAge-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing
Chaudhary S, Zhang S, Zhornitsky S, Chen Y, Chao H, Li C. Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing. NeuroImage 2023, 276: 120207. PMID: 37263454, PMCID: PMC10330646, DOI: 10.1016/j.neuroimage.2023.120207.Peer-Reviewed Original ResearchConceptsFaster reaction timesNegative emotionsAge-related declineEmotional stimuliTrait anxietyAge-related reductionReaction timeEmotion regulation literatureSalient emotional stimuliPositive emotional stimuliFacial emotion processingPrefrontal cortical responsesRostral anterior cingulate cortexWhole-brain regressionAnterior cingulate activityDefault mode networkAnterior cingulate cortexEmotion regulationNeural evidenceEmotion processingDorsolateral PFCStimulus registrationDiminished anxietyPsychophysiological interactionEmotional circuits
2022
Cortical profiles of numerous psychiatric disorders and normal development share a common pattern
Cao Z, Cupertino R, Ottino-Gonzalez J, Murphy A, Pancholi D, Juliano A, Chaarani B, Albaugh M, Yuan D, Schwab N, Stafford J, Goudriaan A, Hutchison K, Li C, Luijten M, Groefsema M, Momenan R, Schmaal L, Sinha R, van Holst R, Veltman D, Wiers R, Porjesz B, Lett T, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Robinson L, Smolka M, Walter H, Winterer J, Schumann G, Whelan R, Bhatt R, Zhu A, Conrod P, Jahanshad N, Thompson P, Mackey S, Garavan H. Cortical profiles of numerous psychiatric disorders and normal development share a common pattern. Molecular Psychiatry 2022, 28: 698-709. PMID: 36380235, DOI: 10.1038/s41380-022-01855-6.Peer-Reviewed Original ResearchConceptsCortical thicknessPsychiatric disordersNumerous psychiatric disordersNeurological disordersDesikan-Killiany atlasLower cortical thicknessNormative maturationAllen Human Brain AtlasHealthy adult participantsCortical maturationExpression of PC1Cortical changesEmergence of psychopathologyBrain maturationPsychiatric diseasesMultiple gene ontology categoriesHuman Brain AtlasCortical profilesPubertal transitionCT differencesDisordersLate childhoodABCD studyAdult participantsNeurobiological basisObjective Sleep-Wake Characteristics Are Associated With Diabetes Symptoms in Young Adults With Type 1 Diabetes
Griggs S, Grey M, Ash GI, Li CR, Crawford SL, Hickman RL. Objective Sleep-Wake Characteristics Are Associated With Diabetes Symptoms in Young Adults With Type 1 Diabetes. The Science Of Diabetes Self-Management And Care 2022, 48: 149-156. PMID: 35446182, PMCID: PMC9157415, DOI: 10.1177/26350106221094521.Peer-Reviewed Original ResearchConceptsBody mass indexSleep-wake characteristicsTotal symptom burdenSleep onset latencySymptom burdenDiabetes symptomsYoung adultsOnset latencyHigher total symptom burdenDistress symptomsDescriptive cross-sectional studyDistress ScaleHigh sleep variabilityShorter total sleep timeType 1 diabetesCross-sectional studyLonger sleep onset latencyPoor sleep efficiencyTotal sleep timeYoung adults ages 18Adults ages 18Pain symptomsT1D durationDiabetes clinicEmotional Distress ScaleBrain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents
Ottino‐González J, Garavan H, Albaugh M, Cao Z, Cupertino R, Schwab N, Spechler P, Allen N, Artiges E, Banaschewski T, Bokde A, Burke Quinlan E, Brühl R, Orr C, Cousijn J, Desrivières S, Flor H, Foxe J, Fröhner J, Goudriaan A, Gowland P, Grigis A, Heinz A, Hester R, Hutchison K, Li C, London E, Lorenzetti V, Luijten M, Nees F, Martín‐Santos R, Martinot J, Millenet S, Momenan R, Paillère Martinot M, Papadopoulos Orfanos D, Paulus M, Poustka L, Schmaal L, Schumann G, Sinha R, Smolka MN, Solowij N, Stein DJ, Stein EA, Uhlmann A, van Holst RJ, Veltman DJ, Walter H, Whelan R, Wiers RW, Yücel M, Zhang S, Jahanshad N, Thompson PM, Conrod P, Mackey S. Brain structural covariance network differences in adults with alcohol dependence and heavy‐drinking adolescents. Addiction 2022, 117: 1312-1325. PMID: 34907616, DOI: 10.1111/add.15772.Peer-Reviewed Original ResearchConceptsAlcohol dependenceHeavy drinking adolescentsStructural covariance networksAge 19Non-dependent controlsPre-existing risk factorsAge 14Cohort of adolescentsCross-sectional analysisRisk factorsAlcohol exposureEnhancing Neuroimaging GeneticsCortical thicknessHazardous drinkersEarly markerMeta-AnalysisNetwork segregationCross-sectional sampleIMAGEN studySubstantial exposureAdultsDrinking adolescentsCovariance networksBrain organizationAdolescentsThe thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson P, Stein D, van den Heuvel O, Vriend C. The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder. Translational Psychiatry 2022, 12: 70. PMID: 35190533, PMCID: PMC8861046, DOI: 10.1038/s41398-022-01823-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMagnetic resonance imagingThalamic volumeOCD patientsThalamic subregionsT1-weighted brain magnetic resonance imagingBrain magnetic resonance imagingClinical-level symptomsLarger thalamic volumesPediatric OCD patientsAdult OCD patientsSeparate multiple linear regression modelsVolumetric group differencesThalamus sizeMedicated patientsAdolescent patientsAnterior thalamusHealthy controlsSubregional volumesGeneral populationMedication statusMultiple comparison correctionPatientsResonance imagingIntracranial volumeClinical and behavior characteristics of individuals who used ketamine
Lee TS, Liu YH, Huang YJ, Tang WK, Wang Y, Hu S, Lin CP, Li CR, Hung CC. Clinical and behavior characteristics of individuals who used ketamine. Scientific Reports 2022, 12: 801. PMID: 35039593, PMCID: PMC8764021, DOI: 10.1038/s41598-022-04832-9.Peer-Reviewed Original ResearchConceptsMemory testLower urinary tract symptomsN-back memory testShort-term recallShort-term memoryDrug-using participantsCigarette smokersImpulsivity measuresTerm recallBehavioral dispositionsPolydrug usersKetamine usersGroup of individualsSex-related behaviorsUrinary tract symptomsPolydrug useDrug-related problemsCross-sectional interviewMemoryRisk behaviorsKetamine useTract symptomsClinical characteristicsParticipantsHIV serostatusPositive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking
Le TM, Malone T, Li CR. Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking. Drug And Alcohol Dependence 2022, 231: 109248. PMID: 34998254, PMCID: PMC8881788, DOI: 10.1016/j.drugalcdep.2021.109248.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPositive alcohol expectanciesAlcohol expectanciesInsular connectivityFunctional connectivityWhole-brain multiple regressionPath analysisNegative emotion processingVentromedial prefrontal cortexSuperior parietal lobuleSuperior frontal gyrusCognitive controlAlcohol stimuliEmotion processingPrefrontal structuresStimulus saliencyFrontal gyrusDrinking motivationsMotivational circuitsInsula connectivityParietal lobuleAdult drinkersPrefrontal cortexInsulaDrinking behavior
2021
Variations in Sleep Characteristics and Glucose Regulation in Young Adults With Type 1 Diabetes
Griggs S, Grey M, Strohl KP, Crawford SL, Margevicius S, Kashyap SR, Li CR, Rajagopalan S, Hickman RL. Variations in Sleep Characteristics and Glucose Regulation in Young Adults With Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2021, 107: e1085-e1095. PMID: 34698348, PMCID: PMC8852208, DOI: 10.1210/clinem/dgab771.Peer-Reviewed Original ResearchConceptsHigh glucose variabilityGlucose variability indicesGlucose variabilityType 1 diabetesSleep-wake characteristicsMore sleep disruptionSleep disruptionContinuous glucose monitorPoor sleepYoung adultsShort sleep durationLower sleep efficiencyMajor psychiatric comorbiditiesVariability indexPsychiatric comorbidityDiabetes careSleep characteristicsSleep efficiencyWrist actigraphySleep durationGlucose regulationGlucose patternsImpaired glucoregulationSleep habitsSleep onsetNeural correlates of individual variation in two-back working memory and the relationship with fluid intelligence
Li G, Chen Y, Le TM, Wang W, Tang X, Li CR. Neural correlates of individual variation in two-back working memory and the relationship with fluid intelligence. Scientific Reports 2021, 11: 9980. PMID: 33976306, PMCID: PMC8113462, DOI: 10.1038/s41598-021-89433-8.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexN-back performanceRight anterior insulaStandard Progressive Matrices testFluid intelligenceNeural correlatesReaction timePre-supplementary motor areaRaven's Standard Progressive Matrices testN-back taskIndividual variationHuman Connectome Project datasetProgressive Matrices TestProlonged response timeBilateral frontoparietal cortexAnterior cingulate cortexTwo-backNeural basisDorsal precuneusRSPM performanceNeural processesNeural substratesAnterior insulaCerebral correlatesCorrect itemsReward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task
Zhornitsky S, Dhingra I, Le TM, Wang W, Li CR, Zhang S. Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task. The International Journal Of Neuropsychopharmacology 2021, 24: 634-644. PMID: 33822080, PMCID: PMC8378081, DOI: 10.1093/ijnp/pyab016.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsCocaine Craving QuestionnaireCCQ scoresRecent cocaine useHealthy controlsMonetary incentive delay taskReward-related responsesCocaine useVentral striatumIncentive delay taskMotor cortexReward responsesPrecentral gyrusCocaine addictionPrimary motor cortexSupplementary motor areaDelay taskIntense drug cravingFunctional magnetic resonance imagingMagnetic resonance imagingDrug-seeking behaviorHigher activationReward-related activityMotor areaWhole brainSex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
Dhingra I, Zhang S, Zhornitsky S, Wang W, Le TM, Li CR. Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neuroscience 2021, 22: 12. PMID: 33639845, PMCID: PMC7913329, DOI: 10.1186/s12868-021-00618-3.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskFunctional magnetic resonance imagingNeural responsesSex differencesReward-related brain activationBilateral orbitofrontal cortexMagnetic resonance imagingIncentive delay taskWhole-brain regressionVisual cortexResonance imagingOrbitofrontal cortexBrain activationWomenSuccess rateFMRI studyMenDelay taskImaging literatureNeural sensitivityCortexNeural basisAffective functionsHigher SR scoresLarge winsMapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group
Cao Z, Ottino‐Gonzalez J, Cupertino RB, Schwab N, Hoke C, Catherine O, Cousijn J, Dagher A, Foxe JJ, Goudriaan AE, Hester R, Hutchison K, Li C, London ED, Lorenzetti V, Luijten M, Martin‐Santos R, Momenan R, Paulus MP, Schmaal L, Sinha R, Sjoerds Z, Solowij N, Stein DJ, Stein EA, Uhlmann A, van Holst R, Veltman DJ, Wiers RW, Yücel M, Zhang S, Jahanshad N, Thompson PM, Conrod P, Mackey S, Garavan H. Mapping cortical and subcortical asymmetries in substance dependence: Findings from the ENIGMA Addiction Working Group. Addiction Biology 2021, 26: e13010. PMID: 33508888, PMCID: PMC8317852, DOI: 10.1111/adb.13010.Peer-Reviewed Original ResearchConceptsENIGMA Addiction Working GroupSubstance dependenceBrain asymmetrySubstance-specific effectsAltered brain structureNondependent participantsStructural brain asymmetrySubcortical asymmetriesNucleus accumbensNicotine dependencePsychiatric diagnosisSubcortical regionsAlcohol dependenceWorking GroupBrain phenotypesBrain structuresVolume asymmetryHemispheric differentiationIndividualsParticipantsPrevious studiesMRI datasetsGroupAccumbensFindings
2020
Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction
Zhang S, Zhornitsky S, Wang W, Le TM, Dhingra I, Chen Y, Li C. Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction. Addiction Biology 2020, 26: e12989. PMID: 33300238, PMCID: PMC8614224, DOI: 10.1111/adb.12989.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsDrug useCocaine addictionFunctional connectivityPrefrontal cortical connectivityState functional connectivityReward circuit dysfunctionRecent cocaine useHealthy control participantsInferior parietal cortexCompulsive drug useHabitual drug useCircuit dysfunctionCocaine withdrawalCocaine-dependent individualsCocaine cravingCortical connectivitySignificant anxietyDorsomedial prefrontalParietal cortexCocaine useIntrinsic connectivitySubcortical hubsDrug seekingThe Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use
Le TM, Wang W, Zhornitsky S, Dhingra I, Chen Y, Zhang S, Li CR. The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use. The International Journal Of Neuropsychopharmacology 2020, 24: 333-343. PMID: 33211853, PMCID: PMC8059487, DOI: 10.1093/ijnp/pyaa086.Peer-Reviewed Original ResearchConceptsSocial supportVentral striatumVS connectivityAlcohol misuseSocial isolationWhole-brain multiple regressionProblem drinkingProblem drinkersAlcohol useResting-state functional magnetic resonanceFunctional magnetic resonanceMiddle frontal gyrusPotential protective factorsProblem alcohol usePrefrontal cortical modulationCognitive controlIndividual differencesNeural processesNeural substratesFrontal gyrusPrefrontal connectivityElevated stress responseFunctional connectivityPath analysisNeural connectivityCatechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression
Li W, Zhao J, Ding K, Chao HH, Li CR, Cheng H, Shen L. Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression. Medical Science Monitor 2020, 26: e923567-1-e923567-10. PMID: 32985495, PMCID: PMC7531203, DOI: 10.12659/msm.923567.Peer-Reviewed Original ResearchConceptsBreast cancer patientsHormonal receptor expressionCancer patientsReceptor expressionMemory impairmentProgesterone receptorBreast cancerEstrogen receptorG genotypeGene polymorphismsCognitive impairmentRisks of chemotherapyBreast cancer survivorsSingle nucleotide polymorphismsProspective memory impairmentCatechol-O-methyltransferase gene polymorphismExtent of deficitsMemory scoresER-/PRBDNF polymorphismCancer survivorsCognitive dysfunctionChemotherapyPatientsCognitive deficits