2024
Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behaviorThe Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Le T, Oba T, Couch L, McInerney L, Li C. The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking. ENeuro 2024, 11: eneuro.0437-23.2024. PMID: 38365840, PMCID: PMC10901196, DOI: 10.1523/eneuro.0437-23.2024.Peer-Reviewed Original ResearchMeSH KeywordsAvoidance LearningHumansIndividualityLearningMagnetic Resonance ImagingPainReinforcement, PsychologyRewardConceptsSuperior frontal gyrusReward-seekingCingulate cortexNeural correlatesPain avoidanceAction biasDorsal anterior cingulate cortexLeft posterior cingulate cortexAction-outcome associationsGo/No-Go taskAnterior cingulate cortexPosterior cingulate cortexImpact of outcomesHigher learning rateReward trialsFrontal gyrusAvoidance learningMidcingulate cortexNeural substratesAssociative learningAction tendenciesPre-SMAAssociated with activationPrecentral gyrusPostcentral gyrus
2019
Interdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Interdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action. Cerebral Cortex 2019, 30: 1662-1676. PMID: 31667492, PMCID: PMC7132903, DOI: 10.1093/cercor/bhz194.Peer-Reviewed Original ResearchMeSH KeywordsAdultAvoidance LearningFemaleHumansIndividualityInhibition, PsychologicalMalePunishmentReinforcement, PsychologyRewardYoung AdultConceptsInhibition of actionNeural correlatesReinforcement Sensitivity TheoryRostral anterior cingulate cortexMiddle frontal gyrusAnterior cingulate cortexPunishment sensitivityReinforcement sensitivityMFG activityIndividual differencesNeural processesReward QuestionnaireTrait sensitivityBrain correlatesNeural substratesFrontal gyrusGo responseRewarded actionsSensitivity theoryIncorrect responsesMediation analysisCingulate cortexRegional activationBehavioral approachAvoidance behaviorReward sensitivity and electrodermal responses to actions and outcomes in a go/no-go task
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Reward sensitivity and electrodermal responses to actions and outcomes in a go/no-go task. PLOS ONE 2019, 14: e0219147. PMID: 31344045, PMCID: PMC6657849, DOI: 10.1371/journal.pone.0219147.Peer-Reviewed Original ResearchConceptsSkin conductance responsesGreater skin conductance responsesReward sensitivityIndividual differencesPhysiological arousalInhibition of actionGo taskAppetitive stimuliTrait sensitivityGo/Go responseConductance responsesSalient eventsBehavioral contingenciesIncorrect responsesElectrodermal responsesPsychophysiological researchAvoidance behaviorArousalSex differencesSuccess rateBehavioral factorsResponse windowSuch outcomesGeneral indexPosterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking
Le TM, Zhornitsky S, Wang W, Ide J, Zhang S, Li CR. Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. Journal Of Neuroscience 2019, 39: 6354-6364. PMID: 31189577, PMCID: PMC6687909, DOI: 10.1523/jneurosci.0508-19.2019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMaladaptive coping mechanismPunishment sensitivityNeural substratesBehavioral avoidanceResponse inhibitionNegative affectAlcohol usePosterior cingulate cortex activationCoping mechanismsProblem drinkingAlcohol misusePCC responseSensation-seeking traitsAvoidance strategiesAlcohol Use Disorders Identification TestHazardous alcohol useAvoidance tendenciesAlcohol Use Disorders Identification Test (AUDIT) scoresGo taskNeural processesReward QuestionnaireAction inhibitionBrain activationCerebral correlates
2015
Individual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits
Hu J, Lee D, Hu S, Zhang S, Chao H, Li CS. Individual variation in the neural processes of motor decisions in the stop signal task: the influence of novelty seeking and harm avoidance personality traits. Brain Structure And Function 2015, 221: 2607-2618. PMID: 25989852, PMCID: PMC4654717, DOI: 10.1007/s00429-015-1061-4.Peer-Reviewed Original ResearchConceptsStop-signal taskHarm avoidanceNeural processesSignal taskPersonality traitsStudy of cognitionWhole-brain regressionRegional brain activationRisk-taking processesCognitive controlExecutive controlStop errorBrain activationFMRI studyBehavioral tasksMotor decisionsFrontopolar cortexMonetary rewardsNovelty seekingRisk-taking responsesBilateral orbitofrontalExplicit manipulationDorsomedial prefrontalRegional activationParahippocampal gyrus