2021
Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group
Rossetti MG, Patalay P, Mackey S, Allen NB, Batalla A, Bellani M, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Li CR, Martin-Santos R, Momenan R, Sinha R, Schmaal L, Sjoerds Z, Solowij N, Suo C, van Holst RJ, Veltman DJ, Yücel M, Thompson PM, Conrod P, Garavan H, Brambilla P, Lorenzetti V. Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group. NeuroImage Clinical 2021, 30: 102636. PMID: 33857771, PMCID: PMC8065340, DOI: 10.1016/j.nicl.2021.102636.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismBrainFemaleGray MatterHumansMagnetic Resonance ImagingMaleNeuroanatomySex FactorsConceptsENIGMA Addiction Working GroupAlcohol dependenceNeuroanatomical differencesAlcohol-dependent menSmaller amygdala volumesGlobal brain measuresGender-related differencesClinical outcomesControl menCorpus callosumAmygdala volumeNeurobiological effectsGM volumeGender differencesSmaller amygdalaStandard drinksBrain regionsIntracranial volumeWorking GroupTotal GMBrain measuresCerebellar GMNeurobiological substratesWomenEducation years
2019
The effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study
Wang W, Zhornitsky S, Chao HH, Levy I, Joormann J, Li CR. The effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study. Behavioural Brain Research 2019, 378: 112301. PMID: 31644928, PMCID: PMC6893150, DOI: 10.1016/j.bbr.2019.112301.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsSocial interactionSocial anxietyCyberball taskNeural processesOccipital cortexBall tossPregenual anterior cingulate cortexAnterior cingulate cortexSex differencesSocial exclusionAnxiety Scale scoresBehavioral performanceOrbitofrontal cortexCingulate cortexSubjective reportsBehavioral burdenEffect of ageObserved sex differencesYoung adultsCerebral responsesAge-related diminutionGame sessionsAnxietyCortexReward sensitivity and electrodermal responses to actions and outcomes in a go/no-go task
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Reward sensitivity and electrodermal responses to actions and outcomes in a go/no-go task. PLOS ONE 2019, 14: e0219147. PMID: 31344045, PMCID: PMC6657849, DOI: 10.1371/journal.pone.0219147.Peer-Reviewed Original ResearchConceptsSkin conductance responsesGreater skin conductance responsesReward sensitivityIndividual differencesPhysiological arousalInhibition of actionGo taskAppetitive stimuliTrait sensitivityGo/Go responseConductance responsesSalient eventsBehavioral contingenciesIncorrect responsesElectrodermal responsesPsychophysiological researchAvoidance behaviorArousalSex differencesSuccess rateBehavioral factorsResponse windowSuch outcomesGeneral indexCue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activity
2017
Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study
Zhang S, Hu S, Chao HH, Li CR. Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study. Brain Structure And Function 2017, 222: 2573-2583. PMID: 28110447, PMCID: PMC5540792, DOI: 10.1007/s00429-016-1358-y.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPosterior cingulate cortexIntraparietal sulcusVentral striatumSupramarginal gyrusVS connectivityFunctional connectivityDorsomedial prefrontal cortexAutomated Anatomic Labeling (AAL) atlasFunctional hemispheric asymmetriesCerebral functional organizationGender differencesHuman Connectome ProjectRight lateralizationSelf-ControlHemispheric lateralizationPrefrontal cortexSaliency responsesBehavioral contingenciesFunctional lateralizationMotivated behaviorHemispheric asymmetryCingulate cortexConnectome ProjectLaterality index
2016
Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait
Kann S, Zhang S, Manza P, Leung HC, Li C. Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait. Brain Connectivity 2016, 6: 724-734. PMID: 27604154, PMCID: PMC5105339, DOI: 10.1089/brain.2016.0443.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior insulaFunctional connectivityLaterality indexDorsomedial prefrontal cortexInferior frontal cortexAutomated Anatomic Labeling (AAL) atlasSuperior parietal lobuleCerebral functional organizationSuperior frontal gyrusPosterior orbital gyrusAttentional orientationAffective processingInsula activationRight lateralizationAffective controlLeft lateralizationSalient stimuliPhysiological arousalTridimensional Personality QuestionnaireFrontal gyrusHemispheric lateralizationSupramarginal gyrusLateralized connectivityParietal lobule
2005
Neuroimaging study of sex differences in the neuropathology of cocaine abuse
Li CS, Kemp K, Milivojevic V, Sinha R. Neuroimaging study of sex differences in the neuropathology of cocaine abuse. Gender Medicine 2005, 2: 174-182. PMID: 16290890, DOI: 10.1016/s1550-8579(05)80046-4.Peer-Reviewed Original ResearchConceptsRegional brain activationBrain activationGreater activationBrain regionsSex differencesScript-guided imagerySubstance abusersCerebral perfusion deficitsBlood oxygenation level-dependent (BOLD) signalSame statistical thresholdCocaine-dependent menCue-induced cravingSuperior frontal gyrusLevel-dependent signalChronic cocaine useMale substance abusersSex-related factorsCocaine use disorderImportant sex differencesLeft uncusStress trialsClinical outcomesPerfusion deficitsRight claustrumPharmacologic challenge