2024
The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Le T, Oba T, Couch L, McInerney L, Li C. The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking. ENeuro 2024, 11: eneuro.0437-23.2024. PMID: 38365840, PMCID: PMC10901196, DOI: 10.1523/eneuro.0437-23.2024.Peer-Reviewed Original ResearchConceptsSuperior frontal gyrusReward-seekingCingulate cortexNeural correlatesPain avoidanceAction biasDorsal anterior cingulate cortexLeft posterior cingulate cortexAction-outcome associationsGo/No-Go taskAnterior cingulate cortexPosterior cingulate cortexImpact of outcomesHigher learning rateReward trialsFrontal gyrusAvoidance learningMidcingulate cortexNeural substratesAssociative learningAction tendenciesPre-SMAAssociated with activationPrecentral gyrusPostcentral gyrus
2022
Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task
Chen Y, Chaudhary S, Li C. Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task. NeuroImage 2022, 264: 119764. PMID: 36427755, PMCID: PMC9837714, DOI: 10.1016/j.neuroimage.2022.119764.Peer-Reviewed Original ResearchConceptsSupplementary motor areaMonetary incentive delay taskMedial orbitofrontal cortexBilateral anterior insulaLoss outcomesAnterior insulaLoss anticipationIncentive delay taskBilateral striatumPrecentral gyrusCingulate cortexBilateral medial orbitofrontal cortexDorsal anterior cingulate cortexRight occipital cortexDelay taskAnterior cingulate cortexPosterior cingulate cortexNeural correlatesActivation likelihood estimationRight thalamusMotor areaOccipital cortexRegional activityDistinct neural activityStriatumLoss and Frontal Striatal Reactivities Characterize Alcohol Use Severity and Rule-Breaking Behavior in Young Adult Drinkers
Li G, Chen Y, Chaudhary S, Tang X, Li CR. Loss and Frontal Striatal Reactivities Characterize Alcohol Use Severity and Rule-Breaking Behavior in Young Adult Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 1007-1016. PMID: 35709958, PMCID: PMC10249655, DOI: 10.1016/j.bpsc.2022.06.001.Peer-Reviewed Original Research
2021
Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task
Zhornitsky S, Dhingra I, Le TM, Wang W, Li CR, Zhang S. Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task. The International Journal Of Neuropsychopharmacology 2021, 24: 634-644. PMID: 33822080, PMCID: PMC8378081, DOI: 10.1093/ijnp/pyab016.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsCocaine Craving QuestionnaireCCQ scoresRecent cocaine useHealthy controlsMonetary incentive delay taskReward-related responsesCocaine useVentral striatumIncentive delay taskMotor cortexReward responsesPrecentral gyrusCocaine addictionPrimary motor cortexSupplementary motor areaDelay taskIntense drug cravingFunctional magnetic resonance imagingMagnetic resonance imagingDrug-seeking behaviorHigher activationReward-related activityMotor areaWhole brainSex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
Dhingra I, Zhang S, Zhornitsky S, Wang W, Le TM, Li CR. Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neuroscience 2021, 22: 12. PMID: 33639845, PMCID: PMC7913329, DOI: 10.1186/s12868-021-00618-3.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskFunctional magnetic resonance imagingNeural responsesSex differencesReward-related brain activationBilateral orbitofrontal cortexMagnetic resonance imagingIncentive delay taskWhole-brain regressionVisual cortexResonance imagingOrbitofrontal cortexBrain activationWomenSuccess rateFMRI studyMenDelay taskImaging literatureNeural sensitivityCortexNeural basisAffective functionsHigher SR scoresLarge wins
2020
Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction
Zhang S, Zhornitsky S, Wang W, Le TM, Dhingra I, Chen Y, Li C. Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction. Addiction Biology 2020, 26: e12989. PMID: 33300238, PMCID: PMC8614224, DOI: 10.1111/adb.12989.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsDrug useCocaine addictionFunctional connectivityPrefrontal cortical connectivityState functional connectivityReward circuit dysfunctionRecent cocaine useHealthy control participantsInferior parietal cortexCompulsive drug useHabitual drug useCircuit dysfunctionCocaine withdrawalCocaine-dependent individualsCocaine cravingCortical connectivitySignificant anxietyDorsomedial prefrontalParietal cortexCocaine useIntrinsic connectivitySubcortical hubsDrug seekingCue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving
Zhang S, Zhornitsky S, Wang W, Dhingra I, Le TM, Li CR. Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving. Drug And Alcohol Dependence 2020, 216: 108240. PMID: 32853997, PMCID: PMC7606798, DOI: 10.1016/j.drugalcdep.2020.108240.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsHabitual drug useCocaine withdrawalCocaine cravingDrug useCue exposureNeutral cue exposureReward circuit dysfunctionCocaine Craving QuestionnaireCocaine cue exposureChronic cocaine useSex differencesCocaine-dependent participantsCircuit dysfunctionFemale CDVentromedial prefrontal cortexCocaine useCocaine addictionFunctional connectivityPrefrontal cortexDependent participantsWithdrawalHigher activationCocainePain and reward circuits antagonistically modulate alcohol expectancy to regulate drinking
Le TM, Zhornitsky S, Zhang S, Li CR. Pain and reward circuits antagonistically modulate alcohol expectancy to regulate drinking. Translational Psychiatry 2020, 10: 220. PMID: 32636394, PMCID: PMC7341762, DOI: 10.1038/s41398-020-00909-z.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexPath modelCue exposure taskWhole-brain regressionAlcohol cue exposurePAG connectivityPotential aversive effectsExposure tasksCue exposureAlcohol expectanciesSocial pleasureDrinking severityOrbitofrontal cortexFMRI dataConnectivity strengthPrecentral gyrusOccipital cortexPSP scoresAlcohol useAversive effectsExcessive drinkingNegative associationExpectancyPleasureCortex
2019
Neural correlates of reward-directed action and inhibition of action
Le TM, Zhang S, Zhornitsky S, Wang W, Li CR. Neural correlates of reward-directed action and inhibition of action. Cortex 2019, 123: 42-56. PMID: 31747630, DOI: 10.1016/j.cortex.2019.10.007.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexInhibition of actionGo trialsReward-directed actionGoal-directed actionsInferior parietal cortexMiddle frontal cortexAnterior cingulate cortexMain effectSignificant main effectVisual attentionNeural correlatesGo taskResponse executionReward valuationNeural processesBrain activationHealthy human adultsNeural responsesReward magnitudeConjunction analysisLarge rewardDorsal ACCCingulate cortexParietal cortexInterdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Interdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action. Cerebral Cortex 2019, 30: 1662-1676. PMID: 31667492, PMCID: PMC7132903, DOI: 10.1093/cercor/bhz194.Peer-Reviewed Original ResearchConceptsInhibition of actionNeural correlatesReinforcement Sensitivity TheoryRostral anterior cingulate cortexMiddle frontal gyrusAnterior cingulate cortexPunishment sensitivityReinforcement sensitivityMFG activityIndividual differencesNeural processesReward QuestionnaireTrait sensitivityBrain correlatesNeural substratesFrontal gyrusGo responseRewarded actionsSensitivity theoryIncorrect responsesMediation analysisCingulate cortexRegional activationBehavioral approachAvoidance behaviorReward sensitivity and electrodermal responses to actions and outcomes in a go/no-go task
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Reward sensitivity and electrodermal responses to actions and outcomes in a go/no-go task. PLOS ONE 2019, 14: e0219147. PMID: 31344045, PMCID: PMC6657849, DOI: 10.1371/journal.pone.0219147.Peer-Reviewed Original ResearchConceptsSkin conductance responsesGreater skin conductance responsesReward sensitivityIndividual differencesPhysiological arousalInhibition of actionGo taskAppetitive stimuliTrait sensitivityGo/Go responseConductance responsesSalient eventsBehavioral contingenciesIncorrect responsesElectrodermal responsesPsychophysiological researchAvoidance behaviorArousalSex differencesSuccess rateBehavioral factorsResponse windowSuch outcomesGeneral indexPosterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking
Le TM, Zhornitsky S, Wang W, Ide J, Zhang S, Li CR. Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. Journal Of Neuroscience 2019, 39: 6354-6364. PMID: 31189577, PMCID: PMC6687909, DOI: 10.1523/jneurosci.0508-19.2019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMaladaptive coping mechanismPunishment sensitivityNeural substratesBehavioral avoidanceResponse inhibitionNegative affectAlcohol usePosterior cingulate cortex activationCoping mechanismsProblem drinkingAlcohol misusePCC responseSensation-seeking traitsAvoidance strategiesAlcohol Use Disorders Identification TestHazardous alcohol useAvoidance tendenciesAlcohol Use Disorders Identification Test (AUDIT) scoresGo taskNeural processesReward QuestionnaireAction inhibitionBrain activationCerebral correlates
2016
Central nervous system regulation of eating: Insights from human brain imaging
Farr OM, Li CS, Mantzoros CS. Central nervous system regulation of eating: Insights from human brain imaging. Metabolism 2016, 65: 699-713. PMID: 27085777, PMCID: PMC4834455, DOI: 10.1016/j.metabol.2016.02.002.Peer-Reviewed Original ResearchConceptsCentral nervous systemCentral nervous system regulationOvereating/obesityBody weight regulationNervous system regulationWeight regulationNervous systemEnergy homeostasisObesity researchAvailable evidenceBrain imagingRespective underlying mechanismsAppetiteHomeostatic controlClinical researchersUnderlying mechanismHuman brain imagingSystem regulationHuman brainExact relative contributionObesityHumansHypothalamusPathogenesisCentral role
2012
The influence of risky and conservative mental sets on cerebral activations of cognitive control
Winkler AD, Hu S, Li CS. The influence of risky and conservative mental sets on cerebral activations of cognitive control. International Journal Of Psychophysiology 2012, 87: 254-261. PMID: 22922525, PMCID: PMC3511622, DOI: 10.1016/j.ijpsycho.2012.08.010.Peer-Reviewed Original ResearchConceptsStop-signal taskMental setCognitive controlSignal taskCerebral activationPre-supplementary motor areaGo reaction timePrevious imaging workReaction timeReward uncertaintyCognitive functioningIndividual differencesStop errorGreater activationNeural responsesSalient eventsContextual effectsImaging workRetrosplenial cortexMore salientAdult participantsMotor areaSuccess trialsCerebral responsesReward