2022
Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients
Chaudhary S, Roy A, Summers C, Zhornitsky S, Ahles T, Li CR, Chao HH. Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients. Scientific Reports 2022, 12: 9567. PMID: 35688928, PMCID: PMC9187668, DOI: 10.1038/s41598-022-13361-4.Peer-Reviewed Original ResearchMeSH KeywordsAndrogen AntagonistsAndrogensHumansHypothalamusIndividualityMaleMemory, Short-TermProstatic NeoplasmsQuality of LifeConceptsAndrogen deprivation therapyProstate cancer patientsQuality of lifeCancer patientsCorrect response rateMonths of ADTLong-term androgen deprivation therapyResponse rateNon-metastatic prostate cancerMontreal Cognitive Assessment scoreProspective observational studyState functional connectivityCognitive Assessment scoreDeprivation therapyHypothalamic connectivityAndrogen deprivationPrognostic markerProstate cancerGonadal axisObservational studyYears of educationQOL effectsControl groupQoLSalience networkThe effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity
Chaudhary S, Zhornitsky S, Roy A, Summers C, Ahles T, Li C, Chao HH. The effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity. Cancer Medicine 2022, 11: 3425-3436. PMID: 35315585, PMCID: PMC9487881, DOI: 10.1002/cam4.4704.Peer-Reviewed Original ResearchMeSH KeywordsAndrogen AntagonistsAndrogensHumansHypothalamusMaleMemory, Short-TermProstatic NeoplasmsQuality of LifeTestosteroneConceptsAndrogen deprivation therapyMid-cingulate cortexEffects of ADTFunctional connectivityPrecentral gyrusN-back taskN-back performanceState functional connectivityMontreal Cognitive Assessment scoreHypothalamic functional connectivityProspective observational studyNonmetastatic prostate cancerProstate cancer patientsCognitive Assessment scoreQuality of lifeSustain attentionAffective functionsDeprivation therapyHypothalamic connectivityYears of educationAndrogen deprivationCorrect response rateQOL scoresCancer patientsClinical correlates
2013
Psychometric properties of the World Health Organization quality of life assessment – brief in methadone patients: a validation study in northern Taiwan
Fu TS, Tuan YC, Yen MY, Wu WH, Huang CW, Chen WT, Li CS, Lee TS. Psychometric properties of the World Health Organization quality of life assessment – brief in methadone patients: a validation study in northern Taiwan. Harm Reduction Journal 2013, 10: 37. PMID: 24325611, PMCID: PMC4029077, DOI: 10.1186/1477-7517-10-37.Peer-Reviewed Original ResearchConceptsInjection drug usersWorld Health Organization QualityHealth Organization QualityDrug usersWHOQOL-BREFOrganization QualityFuture treatment outcome studiesMethadone maintenance treatmentBackgroundQuality of lifeImportant outcome measureTreatment outcome studiesInternal consistencyItem-domain correlationsCriterion-related validityPsychometric propertiesMaintenance treatmentMethadone patientsTest-retest reliabilityGeneral healthOverall QoLOutcome measuresOutcome studiesItem response distributionsQOL characteristicsDomain scoresEffects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study
Chao HH, Hu S, Ide JS, Uchio E, Zhang S, Rose M, Concato J, Li CS. Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study. PLOS ONE 2013, 8: e72032. PMID: 23977199, PMCID: PMC3747074, DOI: 10.1371/journal.pone.0072032.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsGray matter volumeMagnetic resonance imagingPrimary motor cortexCancer patientsVoxel-based morphometryMatter volumeMotor cortexProstate cancerEffects of ADTLow-risk prostate cancerCerebral gray matter volumeStatistical Parametric Mapping 8Utility of brainControl participantsHigh-resolution magnetic resonance imagingPotential side effectsQuality of lifeResolution magnetic resonance imagingSame time pointsFunctional magnetic resonance imagingHigh-resolution T1Prefrontal cortical activationDorsolateral prefrontal cortexImprovement of quality of life in methadone treatment patients in northern Taiwan: a follow-up study
Chou YC, Shih SF, Tsai WD, Li CS, Xu K, Lee TS. Improvement of quality of life in methadone treatment patients in northern Taiwan: a follow-up study. BMC Psychiatry 2013, 13: 190. PMID: 23865898, PMCID: PMC3722024, DOI: 10.1186/1471-244x-13-190.Peer-Reviewed Original ResearchConceptsMethadone maintenance treatmentLong-term qualityMaintenance treatmentMethadone treatment patientsHeroin-dependent individualsWHOQOL-BREF questionnaireQuality of lifeSocial relationship domainLong-term improvementClinical characteristicsTreatment patientsBackgroundThis studyHeroin usersSignificant improvementWHOQOL-BREFImprovement of qualityMethodsThe sampleConsent formNorthern TaiwanRelationship domainPatientsBaselineMonthsTreatmentEnvironmental domains
2012
Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis
Chao HH, Uchio E, Zhang S, Hu S, Bednarski SR, Luo X, Rose M, Concato J, Li CS. Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis. BMC Cancer 2012, 12: 371. PMID: 22925152, PMCID: PMC3502584, DOI: 10.1186/1471-2407-12-371.Peer-Reviewed Original ResearchMeSH KeywordsAgedAndrogen AntagonistsAnilidesAntineoplastic Agents, HormonalBrainCognitionCohort StudiesGoserelinHumansMagnetic Resonance ImagingMaleMemoryMiddle AgedNeuropsychological TestsNitrilesProspective StudiesProstatic NeoplasmsPsychomotor PerformanceQuality of LifeSurveys and QuestionnairesTosyl CompoundsTreatment OutcomeConceptsAndrogen deprivation therapyFunctional magnetic resonance imagingProspective observational cohort analysisObservational cohort analysisN-back taskStop-signal taskCognitive controlProstate cancerBrain activationCohort analysisLow-risk prostate cancerNon-metastatic prostate cancerVeterans Affairs Medical CenterLong-term clinical implicationsBrain connectivityProstate cancer patientsPrefrontal cortical activationQuality of lifeFunctional brain connectivityMagnetic resonance imagingMedial prefrontal cortexParticular clinical concernDeprivation therapyADT useAndrogen deprivation