2018
Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction
Wang W, Worhunsky PD, Zhang S, Le TM, Potenza MN, Li CR. Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction. Drug And Alcohol Dependence 2018, 192: 137-145. PMID: 30248560, PMCID: PMC6200592, DOI: 10.1016/j.drugalcdep.2018.07.037.Peer-Reviewed Original Research
2013
Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCerebral CortexCocaine-Related DisordersCognition DisordersFemaleHumansImage Processing, Computer-AssistedInhibition, PsychologicalMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedModels, NeurologicalNeural PathwaysNeuropsychological TestsOxygenPhotic StimulationReaction TimeConceptsFunctional magnetic resonance imagingStop-signal taskCD individualsCerebral activationPrecuneus/posterior cingulate cortexSystolic blood pressureInfluence of methylphenidateEffects of methylphenidateMagnetic resonance imagingPosterior cingulate cortexBrain imaging studiesCocaine-addicted individualsDefault mode networkAgonist therapyBlood pressureIntravenous methylphenidateCortico-striatoHealthy controlsCocaine-dependent individualsThalamic activationCingulate cortexResonance imagingBrain regionsMethylphenidateCocaine dependence
2011
Deficits in default mode network activity preceding error in cocaine dependent individuals
Bednarski SR, Zhang S, Hong KI, Sinha R, Rounsaville BJ, Li CS. Deficits in default mode network activity preceding error in cocaine dependent individuals. Drug And Alcohol Dependence 2011, 119: e51-e57. PMID: 21703783, PMCID: PMC3188675, DOI: 10.1016/j.drugalcdep.2011.05.026.Peer-Reviewed Original ResearchConceptsDefault mode networkCocaine dependenceCocaine useHealthy controlsTask-related cerebral activationBlood oxygenation level-dependent (BOLD) signalDemographics-matched healthy controlsGray matter volumeDefault mode network activityLevel-dependent signalChronic cocaine useRegional brain activationPosterior cingulate cortexStatistical parametric mappingCerebral functionBilateral precuneusCocaine-dependent individualsCerebral activationHealthy peopleMatter volumeCingulate cortexVentromedial prefrontal cortexBrain regionsCognitive deficitsCocaine misuse
2008
Error-specific medial cortical and subcortical activity during the stop signal task: A functional magnetic resonance imaging study
Li C, Yan P, Chao H, Sinha R, Paliwal P, Constable RT, Zhang S, Lee T. Error-specific medial cortical and subcortical activity during the stop signal task: A functional magnetic resonance imaging study. Neuroscience 2008, 155: 1142-1151. PMID: 18674592, PMCID: PMC2605269, DOI: 10.1016/j.neuroscience.2008.06.062.Peer-Reviewed Original ResearchConceptsPost-error behavioral adjustmentPost-error slowingBehavioral adjustmentSignal taskFunctional magnetic resonance imaging studyConflict monitoring hypothesisError-related activityFunctional magnetic resonance imagingHigh-conflict trialsTrial reaction timeStop-signal taskMedial cortical regionsCortical brain regionsMagnetic resonance imaging studyResonance imaging studyElicit errorsBrain activationLess activationSubcortical activityCortical activityRetrosplenial cortexMonitoring hypothesisBehavioral outputBrain regionsCortical regionsNeural Correlates of Post-error Slowing during a Stop Signal Task: A Functional Magnetic Resonance Imaging Study
Li CS, Huang C, Yan P, Paliwal P, Constable RT, Sinha R. Neural Correlates of Post-error Slowing during a Stop Signal Task: A Functional Magnetic Resonance Imaging Study. Journal Of Cognitive Neuroscience 2008, 20: 1021-1029. PMID: 18211230, PMCID: PMC2597347, DOI: 10.1162/jocn.2008.20071.Peer-Reviewed Original ResearchConceptsStop-signal taskPost-error slowingBehavioral adjustmentNeural correlatesSignal taskFunctional magnetic resonance imaging studyFunctional magnetic resonance imagingVentrolateral prefrontal cortexCortical brain regionsMagnetic resonance imaging studyResonance imaging studyElicit errorsError processingStop trialsPrefrontal cortexNeural circuitryGo signalRegional activationBehavioral outputBrain regionsStop signalReaction timeConflicting responsesTaskImaging studies
2002
A perceptual level mechanism of the inhibition of return in oculomotor planning
Li CS, Lin SC. A perceptual level mechanism of the inhibition of return in oculomotor planning. Brain Research 2002, 14: 269-276. PMID: 12067700, DOI: 10.1016/s0926-6410(02)00129-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceCuesHumansInhibition, PsychologicalPerceptionPhotic StimulationPsychomotor PerformanceSaccadesConceptsInhibition of returnCue-target onset asynchroniesPerceptual inputOnset asynchronyAttention gatingMotor processesOculomotor planningNeural mechanismsBehavioral tasksManual responsesMotor effectorsVisuomotor controlVisual targetsVisual environmentEye movementsMotor responseSpatial locationCuesCurrent studyLevel mechanismsSaccadesSeries of experimentsTime courseAsynchronySimilar patternImpairment of temporal attention in patients with schizophrenia
Li CS, Lin WH, Yang YY, Huang CC, Chen TW, Chen YC. Impairment of temporal attention in patients with schizophrenia. Neuroreport 2002, 13: 1427-1430. PMID: 12167767, DOI: 10.1097/00001756-200208070-00016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAttentionCognition DisordersFemaleHumansMalePhotic StimulationSchizophreniaConceptsRapid serial visual presentation taskCore cognitive deficitVisual presentation taskEducation-matched control subjectsNumber of distractorsSignal detection theoryAttentional blinkT2 detectionTemporal attentionPresentation taskAttention impairmentVisual stimuliTemporal deploymentCognitive deficitsDetection theorySchizophrenia patientsSchizophrenia subjectsRapid successionSchizophreniaImpairmentTemporal gatingAttentionDistractorsBlinkStimuliInhibition of return in temporal order saccades
Li CS, Lin SC. Inhibition of return in temporal order saccades. Vision Research 2002, 42: 2089-2093. PMID: 12169428, DOI: 10.1016/s0042-6989(02)00123-2.Peer-Reviewed Original ResearchImpaired detection of visual motion in schizophrenia patients
Li CS. Impaired detection of visual motion in schizophrenia patients. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2002, 26: 929-934. PMID: 12369268, DOI: 10.1016/s0278-5846(02)00207-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleHumansMaleMotion PerceptionPhotic StimulationRegression AnalysisSchizophreniaConceptsSchizophrenia patientsNormal controlsNormal subjectsPatientsSignal detection theorySimilar deficitsImpaired detectionCore deficitAttention impairmentMotion stimuliSensory modalitiesVisual tasksResponse biasVisual motionRecent reportsAuditory detectionDetection theoryTrialsDeficitsRandom dotsPsychometric functionsSignal intensitySensitivity variesGroupCoherent direction