2024
Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory
Li G, Cao Y, Yang C, Li X, Yang Y, Yang L, Hao D, Li C. Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory. Quantitative Imaging In Medicine And Surgery 2024, 14: 4972986-4974986. PMID: 39022273, PMCID: PMC11250293, DOI: 10.21037/qims-24-156.Peer-Reviewed Original ResearchAlcohol use severityWorking memoryPittsburgh Sleep Quality IndexAlcohol misuseSex differencesHuman Connectome ProjectPath modelAssociated with working memory deficitsNeural correlates of working memoryPittsburgh Sleep Quality Index scoreCorrelates of working memoryPrefrontal cortex responsesImpact working memoryWhole-brain regressionComorbid alcohol misusePotential sex differencesManipulation of informationImpact of drinkingDLPFC activationDrinking severityPublished routinesNeural correlatesMemory deficitsNeural measuresSleep deficiencySex differences in the effects of individual anxiety state on regional responses to negative emotional scenes
Chaudhary S, Wong H, Chen Y, Zhang S, Li C. Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes. Biology Of Sex Differences 2024, 15: 15. PMID: 38351045, PMCID: PMC10863151, DOI: 10.1186/s13293-024-00591-6.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexState-Trait Anxiety InventoryFunctional magnetic resonance imagingState-Trait Anxiety Inventory scoresSuperior frontal gyrusGeneralized psychophysiological interactionEmotional processingFrontal gyrusLingual gyrusMedial prefrontal cortex connectivityMedial prefrontal cortex activationSex differencesRight inferior frontal gyrusResponse to negative emotionsRight superior frontal gyrusFunctional magnetic resonance imaging dataReaction timeImpact emotional processingNegative emotion processingInferior frontal gyrusLeft parahippocampal gyrusNegative emotional scenesMarkers of anxietyRepeated-measures analysis of covarianceLevels of anxiety
2023
A 2-year mental health follow-up study subsequent to COVID-19
Hu K, Hu Y, Godfrey K, Li Q, Li C. A 2-year mental health follow-up study subsequent to COVID-19. Psychiatry Research 2023, 333: 115684. PMID: 38219344, DOI: 10.1016/j.psychres.2023.115684.Peer-Reviewed Original ResearchConceptsAcademic difficultiesCollege studentsMeasures of lonelinessPandemic onsetPandemic-induced stressMental health impactsPsychological symptomsSex differencesHeightened fearEmotional statesMental healthLearning difficultiesParticipants' fearLonelinessFearStudentsEducation of college studentsDifficultiesResilienceMid-2022HappinessOnsetSymptomsUnited StatesParticipantsSex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala
Chaudhary S, Hu S, Hu K, Dominguez J, Chao H, Li C. Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala. Journal Of Affective Disorders Reports 2023, 14: 100646. PMID: 38105798, PMCID: PMC10723810, DOI: 10.1016/j.jadr.2023.100646.Peer-Reviewed Original ResearchResting-state functional connectivityAmygdala resting-state functional connectivityTrait anxietyFunctional connectivitySex differencesInferior temporal gyrusCalcarine cortexTask-based dataNeural basisIndividual differencesEmotional traitsSupramarginal gyrusEmotional disordersTemporal gyrusNeural markersPosterior insulaAnxietyEffect of ageGyrusIndependent samplesMultiple regressionCorrelatesAmygdalaResults AnxietyCortex
2022
Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability
Chen Y, Ide JS, Li CS, Chaudhary S, Le TM, Wang W, Zhornitsky S, Zhang S, Li C. Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability. Human Brain Mapping 2022, 43: 2634-2652. PMID: 35212098, PMCID: PMC9057091, DOI: 10.1002/hbm.25810.Peer-Reviewed Original ResearchConceptsGray matter volumeImpulsivity traitsPositive urgencyVolumetric correlatesSensation seekingHigher positive urgencyMid-cingulate cortexSex differencesVoxel-based morphometry analysisSmaller gray matter volumeImpulsivity dimensionsSubsample of twinsDistinct correlatesCingulate cortexPrecentral gyrusSubcortical gray matter volumesMatter volumeTotal intracranial volumeSeekingImpulsivityMorphometry analysisPrevious researchInsulaCorrelatesGirlsStriatal gray matter volumes, externalizing traits, and N-back task performance: An exploratory study of sex differences using the human connectome project data
Chen Y, Li C. Striatal gray matter volumes, externalizing traits, and N-back task performance: An exploratory study of sex differences using the human connectome project data. Journal Of Experimental Psychopathology 2022, 13: 20438087221080057. DOI: 10.1177/20438087221080057.Peer-Reviewed Original Research
2021
Depression Mediates the Relationship between Childhood Trauma and Internet Addiction in Female but Not Male Chinese Adolescents and Young Adults
Dong X, Zhang R, Zhornitsky S, Le TM, Wang W, Li CR, Zhang S. Depression Mediates the Relationship between Childhood Trauma and Internet Addiction in Female but Not Male Chinese Adolescents and Young Adults. Journal Of Clinical Medicine 2021, 10: 5015. PMID: 34768534, PMCID: PMC8584624, DOI: 10.3390/jcm10215015.Peer-Reviewed Original ResearchChildhood traumaYoung adultsSex differencesPsychological risk factorsRisk factorsSevere depressionSignificant associationSociodemographic characteristicsTraumaFuture preventionControl participantsDepressionIntervention strategiesStandardized assessmentSeverityAddictionFemalesMalesEmotional neglectAdultsAdolescentsSexual abuseBehavioral addictionsSex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults
Chen Y, Li G, Ide J, Luo X, Li C. Sex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults. Neuroimage Reports 2021, 1: 100025. DOI: 10.1016/j.ynirp.2021.100025.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderADHD total scoreGroup 2Functional connectivityDorsal striatumGroup 3Symptom severityGroup 1Sex differencesTotal scoreFrontal gyrusRight inferior parietal gyrusRight superior frontal gyrusBasal ganglia dysfunctionCaudate functional connectivitySupplementary motor areaDorsal anterior cingulate cortexAnterior cingulate cortexSeed-based correlationSuperior frontal gyrusGreater symptom severityInferior parietal gyrusDeficit hyperactivity disorderGanglia dysfunctionInferior frontal gyrusSex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
Grace S, Rossetti MG, Allen N, Batalla A, Bellani M, Brambilla P, Chye Y, Cousijn J, Goudriaan AE, Hester R, Hutchison K, Labuschagne I, Momenan R, Martin-Santos R, Rendell P, Solowij N, Sinha R, Li CR, Schmaal L, Sjoerds Z, Suo C, Terrett G, van Holst RJ, Veltman DJ, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Lorenzetti V. Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group. Translational Psychiatry 2021, 11: 156. PMID: 33664226, PMCID: PMC7933136, DOI: 10.1038/s41398-021-01204-1.Peer-Reviewed Original ResearchConceptsENIGMA Addiction Working GroupAlcohol dependenceAmygdala subregionsAlcohol-dependent malesUnderlying neurobiological mechanismsSex differencesSubfield volumesTotal amygdalaAlcohol doseBasolateral nucleusAnimal modelsMale controlsWorking GroupAmygdalar subregionsMental healthNeurobiological mechanismsComparison groupCognitive problemsHippocampusMalesFemalesDistinct mechanismsLittle evidenceGroupAmygdalaSex differences in neural responses to reward and the influences of individual reward and punishment sensitivity
Dhingra I, Zhang S, Zhornitsky S, Wang W, Le TM, Li CR. Sex differences in neural responses to reward and the influences of individual reward and punishment sensitivity. BMC Neuroscience 2021, 22: 12. PMID: 33639845, PMCID: PMC7913329, DOI: 10.1186/s12868-021-00618-3.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskFunctional magnetic resonance imagingNeural responsesSex differencesReward-related brain activationBilateral orbitofrontal cortexMagnetic resonance imagingIncentive delay taskWhole-brain regressionVisual cortexResonance imagingOrbitofrontal cortexBrain activationWomenSuccess rateFMRI studyMenDelay taskImaging literatureNeural sensitivityCortexNeural basisAffective functionsHigher SR scoresLarge wins
2020
Sex Differences in Neural Responses to the Perception of Social Interactions
Li G, Chen Y, Wang W, Dhingra I, Zhornitsky S, Tang X, Li CR. Sex Differences in Neural Responses to the Perception of Social Interactions. Frontiers In Human Neuroscience 2020, 14: 565132. PMID: 33061901, PMCID: PMC7518190, DOI: 10.3389/fnhum.2020.565132.Peer-Reviewed Original ResearchMiddle frontal gyrusBilateral anterior insulaAnterior insulaSocial interactionHigher activationNeural responsesRight inferior frontal cortexSex differencesPre-supplementary motor areaSocial cognition tasksParacentral lobuleRight superior temporal gyrusWhole-brain regressionInferior frontal cortexSuperior temporal gyrusLower activationMedial orbitofrontal cortexPosterior cingulate cortexHuman Connectome Project dataCognition tasksFacial emotionsNeural processesFrontal gyrusTemporal gyrusSelf-ReportCue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving
Zhang S, Zhornitsky S, Wang W, Dhingra I, Le TM, Li CR. Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving. Drug And Alcohol Dependence 2020, 216: 108240. PMID: 32853997, PMCID: PMC7606798, DOI: 10.1016/j.drugalcdep.2020.108240.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsHabitual drug useCocaine withdrawalCocaine cravingDrug useCue exposureNeutral cue exposureReward circuit dysfunctionCocaine Craving QuestionnaireCocaine cue exposureChronic cocaine useSex differencesCocaine-dependent participantsCircuit dysfunctionFemale CDVentromedial prefrontal cortexCocaine useCocaine addictionFunctional connectivityPrefrontal cortexDependent participantsWithdrawalHigher activationCocaineNeural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity
Li G, Zhang S, Le TM, Tang X, Li CR. Neural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity. Cerebral Cortex Communications 2020, 1: tgaa025. PMID: 32864617, PMCID: PMC7446303, DOI: 10.1093/texcom/tgaa025.Peer-Reviewed Original ResearchGambling TaskNeural processesImpulse controlRegional activationSex differencesDorsal anterior cingulate cortexPrefrontal cortical activationAnterior cingulate cortexReaction timeHuman Connectome ProjectCautious respondingReward sensitivityIndividual variationNeural responsesBehavioral measuresAngular gyrusLonger reaction timesPrefrontal cortexImpulsivityCingulate cortexCortical activationConnectome ProjectHigher activationTaskReward
2019
The effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study
Wang W, Zhornitsky S, Chao HH, Levy I, Joormann J, Li CR. The effects of age on cerebral responses to self-initiated actions during social interactions: An exploratory study. Behavioural Brain Research 2019, 378: 112301. PMID: 31644928, PMCID: PMC6893150, DOI: 10.1016/j.bbr.2019.112301.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsSocial interactionSocial anxietyCyberball taskNeural processesOccipital cortexBall tossPregenual anterior cingulate cortexAnterior cingulate cortexSex differencesSocial exclusionAnxiety Scale scoresBehavioral performanceOrbitofrontal cortexCingulate cortexSubjective reportsBehavioral burdenEffect of ageObserved sex differencesYoung adultsCerebral responsesAge-related diminutionGame sessionsAnxietyCortexReward sensitivity and electrodermal responses to actions and outcomes in a go/no-go task
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Reward sensitivity and electrodermal responses to actions and outcomes in a go/no-go task. PLOS ONE 2019, 14: e0219147. PMID: 31344045, PMCID: PMC6657849, DOI: 10.1371/journal.pone.0219147.Peer-Reviewed Original ResearchConceptsSkin conductance responsesGreater skin conductance responsesReward sensitivityIndividual differencesPhysiological arousalInhibition of actionGo taskAppetitive stimuliTrait sensitivityGo/Go responseConductance responsesSalient eventsBehavioral contingenciesIncorrect responsesElectrodermal responsesPsychophysiological researchAvoidance behaviorArousalSex differencesSuccess rateBehavioral factorsResponse windowSuch outcomesGeneral index
2018
Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers
Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestResting-state functional connectivityThalamic connectivityCaudate connectivityFrontal associationThalamic dysfunctionCaudate headProblem drinkingWhole-brain linear regressionAE scoreSubcortical structuresFunctional connectivityBilateral caudate headRight caudate headDisorders Identification TestSex differencesThalamic subdivisionsThalamic subregionsParietal associationAlcohol misuseThalamusWhite matter tractographyAUDIT scoresNondependent drinkersAlcohol expectanciesThalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use
Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR. Thalamic Cortical Error–Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 868-877. PMID: 29859929, PMCID: PMC6177312, DOI: 10.1016/j.bpsc.2018.04.008.Peer-Reviewed Original ResearchConceptsWhole-brain linear regressionError-related activationSex differencesBilateral dorsal anterior cingulate cortexAlcohol Use Disorders Identification Test (AUDIT) scoresSocial drinkersDorsal anterior cingulate cortexSubstance use disordersAnterior cingulate cortexFunctional magnetic resonance imagingMagnetic resonance imagingSuperior temporal cortexStatistical parametric mappingProblem alcohol useBilateral thalamusAlcohol drinkersAdult social drinkersStop-signal taskMale social drinkersTemporal cortexUse disordersCerebral activationIndependent sample t-testCingulate cortexSubcortical regionsResting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers
Hu S, Ide JS, Chao HH, Zhornitsky S, Fischer KA, Wang W, Zhang S, Li CR. Resting state functional connectivity of the amygdala and problem drinking in non-dependent alcohol drinkers. Drug And Alcohol Dependence 2018, 185: 173-180. PMID: 29454928, PMCID: PMC5889735, DOI: 10.1016/j.drugalcdep.2017.11.026.Peer-Reviewed Original ResearchConceptsState functional connectivityDorsal anterior cingulate cortexAlcohol misuseAlcohol drinkersFunctional connectivityInvolvement scoreProblem drinkingSubstance useWhole-brain rsFCComorbid substance useAmygdala-prefrontal cortical circuitAnterior cingulate cortexStatistical parametric mappingPotential sex differencesPrefrontal cortical structuresAmygdala connectivityCortical functionCortical circuitsCingulate cortexAmygdalaCortical structuresParametric mappingSex differencesDrinkingDrinkers
2017
Depression in chronic ketamine users: Sex differences and neural bases
Li CR, Zhang S, Hung CC, Chen CM, Duann JR, Lin CP, Lee TS. Depression in chronic ketamine users: Sex differences and neural bases. Psychiatry Research Neuroimaging 2017, 269: 1-8. PMID: 28892733, PMCID: PMC5634929, DOI: 10.1016/j.pscychresns.2017.09.001.Peer-Reviewed Original ResearchConceptsHealthy controlsSgACC connectivityChronic ketamine usersKetamine usersOrbitofrontal cortexEpidemiological Studies Depression ScaleSubgenual anterior cingulate cortexSex differencesPathogenesis of depressionCES-D scoresState functional connectivityBilateral superior temporal gyrusChronic ketamine useAnterior cingulate cortexSuperior temporal gyrusNeural basisDepression ScaleDorsomedial prefrontal cortexDepression scoresDepression severityKetamine useCingulate cortexTemporal gyrusFunctional connectivityPrefrontal cortexSex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study
Ide JS, Zhornitsky S, Hu S, Zhang S, Krystal JH, Li CR. Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study. NeuroImage Clinical 2017, 14: 750-759. PMID: 28413777, PMCID: PMC5385596, DOI: 10.1016/j.nicl.2017.03.015.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesGray matter volumeAlcohol expectanciesAlcohol Use Disorders Identification TestSocial drinkersNon-dependent social drinkersProblem drinkingRole of impulsivityBrain imaging studiesRight posterior insulaSex differencesStructural brain imagingStructural brain imaging studiesNeural basisDisorders Identification TestBarratt impulsivityPsychological factorsImpulsivityMediation analysisPosterior insulaDependent individualsRisk factorsAlcohol misuseLinear modelingGeneral linear modeling