2022
Problem drinking and the interaction of reward, negative emotion, and cognitive control circuits during cue-elicited craving
Le T, Chen Y, Chaudhary S, Li C. Problem drinking and the interaction of reward, negative emotion, and cognitive control circuits during cue-elicited craving. Addiction Neuroscience 2022, 1: 100004. DOI: 10.1016/j.addicn.2021.100004.Peer-Reviewed Original ResearchCognitive control circuitsPositive alcohol expectanciesNegative emotionsAlcohol use severityCognitive controlMotivational processesCue exposureAlcohol expectanciesUse severityAlcohol useAlcohol cue exposureCue-elicited cravingSocial isolationIndividual differencesReward responsesNegative reinforcementAdult drinkersEmotionsPath modelProblem drinkingActivity differencesRewardDrinking behaviorCravingControl process
2021
Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task
Zhornitsky S, Dhingra I, Le TM, Wang W, Li CR, Zhang S. Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task. The International Journal Of Neuropsychopharmacology 2021, 24: 634-644. PMID: 33822080, PMCID: PMC8378081, DOI: 10.1093/ijnp/pyab016.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsCocaine Craving QuestionnaireCCQ scoresRecent cocaine useHealthy controlsMonetary incentive delay taskReward-related responsesCocaine useVentral striatumIncentive delay taskMotor cortexReward responsesPrecentral gyrusCocaine addictionPrimary motor cortexSupplementary motor areaDelay taskIntense drug cravingFunctional magnetic resonance imagingMagnetic resonance imagingDrug-seeking behaviorHigher activationReward-related activityMotor areaWhole brain