2024
Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunction
2020
Functional disconnection between subsystems of the default mode network in schizophrenia
Fan F, Tan S, Huang J, Chen S, Fan H, Wang Z, Li CR, Tan Y. Functional disconnection between subsystems of the default mode network in schizophrenia. Psychological Medicine 2020, 52: 2270-2280. PMID: 33183375, DOI: 10.1017/s003329172000416x.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaDysfunctional default mode networkDefault mode networkRecurrent schizophreniaIllness durationHealthy controlsSchizophrenia patientsConnectivity strengthResting-state functional connectivity analysisReduced connectivity strengthMode networkFunctional connectivity analysisClinical symptomsPatient groupConnectivity deficitsEarly diagnosisFunctional disconnectionIndependent cohortRES groupMTL dysfunctionPatientsDMN subsystemsFunctional connectivitySchizophreniaMTL subsystem