2024
The inter-related effects of alcohol use severity and sleep deficiency on semantic processing in young adults
Li G, Zhong D, Zhang N, Dong J, Yan Y, Xu Q, Xu S, Yang L, Hao D, Li C. The inter-related effects of alcohol use severity and sleep deficiency on semantic processing in young adults. Neuroscience 2024, 555: 116-124. PMID: 39059740, DOI: 10.1016/j.neuroscience.2024.07.025.Peer-Reviewed Original ResearchMiddle frontal gyrusSemantic processingPittsburgh Sleep Quality IndexPrecentral gyrusPittsburgh Sleep Quality Index scoreAlcohol misuseNeural correlates of semantic processingMiddle frontal gyrus activationRight middle frontal gyrusSeverity of alcohol useAlcohol use severityAssociated with deficitsPrecentral gyrus activationLeft precentral gyrusInfluence of sleep qualityYoung adultsWord comprehensionHuman Connectome Project dataFrontal gyrusNeural correlatesConsumption severityLanguage tasksSleep deficiencyNeural mechanismsMediation analysisThe Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Le T, Oba T, Couch L, McInerney L, Li C. The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking. ENeuro 2024, 11: eneuro.0437-23.2024. PMID: 38365840, PMCID: PMC10901196, DOI: 10.1523/eneuro.0437-23.2024.Peer-Reviewed Original ResearchConceptsSuperior frontal gyrusReward-seekingCingulate cortexNeural correlatesPain avoidanceAction biasDorsal anterior cingulate cortexLeft posterior cingulate cortexAction-outcome associationsGo/No-Go taskAnterior cingulate cortexPosterior cingulate cortexImpact of outcomesHigher learning rateReward trialsFrontal gyrusAvoidance learningMidcingulate cortexNeural substratesAssociative learningAction tendenciesPre-SMAAssociated with activationPrecentral gyrusPostcentral gyrusSex differences in the effects of individual anxiety state on regional responses to negative emotional scenes
Chaudhary S, Wong H, Chen Y, Zhang S, Li C. Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes. Biology Of Sex Differences 2024, 15: 15. PMID: 38351045, PMCID: PMC10863151, DOI: 10.1186/s13293-024-00591-6.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexState-Trait Anxiety InventoryFunctional magnetic resonance imagingState-Trait Anxiety Inventory scoresSuperior frontal gyrusGeneralized psychophysiological interactionEmotional processingFrontal gyrusLingual gyrusMedial prefrontal cortex connectivityMedial prefrontal cortex activationSex differencesRight inferior frontal gyrusResponse to negative emotionsRight superior frontal gyrusFunctional magnetic resonance imaging dataReaction timeImpact emotional processingNegative emotion processingInferior frontal gyrusLeft parahippocampal gyrusNegative emotional scenesMarkers of anxietyRepeated-measures analysis of covarianceLevels of anxiety
2022
Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking
Le TM, Malone T, Li CR. Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking. Drug And Alcohol Dependence 2022, 231: 109248. PMID: 34998254, PMCID: PMC8881788, DOI: 10.1016/j.drugalcdep.2021.109248.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPositive alcohol expectanciesAlcohol expectanciesInsular connectivityFunctional connectivityWhole-brain multiple regressionPath analysisNegative emotion processingVentromedial prefrontal cortexSuperior parietal lobuleSuperior frontal gyrusCognitive controlAlcohol stimuliEmotion processingPrefrontal structuresStimulus saliencyFrontal gyrusDrinking motivationsMotivational circuitsInsula connectivityParietal lobuleAdult drinkersPrefrontal cortexInsulaDrinking behavior
2021
Sex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults
Chen Y, Li G, Ide J, Luo X, Li C. Sex differences in attention deficit hyperactivity symptom severity and functional connectivity of the dorsal striatum in young adults. Neuroimage Reports 2021, 1: 100025. DOI: 10.1016/j.ynirp.2021.100025.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderADHD total scoreGroup 2Functional connectivityDorsal striatumGroup 3Symptom severityGroup 1Sex differencesTotal scoreFrontal gyrusRight inferior parietal gyrusRight superior frontal gyrusBasal ganglia dysfunctionCaudate functional connectivitySupplementary motor areaDorsal anterior cingulate cortexAnterior cingulate cortexSeed-based correlationSuperior frontal gyrusGreater symptom severityInferior parietal gyrusDeficit hyperactivity disorderGanglia dysfunctionInferior frontal gyrusDistinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics
Le TM, Potvin S, Zhornitsky S, Li CR. Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. Neuroscience & Biobehavioral Reviews 2021, 127: 255-269. PMID: 33933507, PMCID: PMC8411123, DOI: 10.1016/j.neubiorev.2021.04.028.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexMiddle frontal gyrusHealthy controlsLeft dorsal anterior cingulate cortexMFG activationSubstance use statusPrefrontal cortical dysfunctionAnterior cingulate cortexPrefrontal cortical regionsResponse inhibitionPopulation characteristicsImpaired task performanceInhibitory control deficitsCortical dysfunctionCerebral functionBenefits of abstinenceNicotine usersCortical activationCingulate cortexCortical regionsFrontal gyrusBrain activationDrug addictionUse statusControl deficits
2020
The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use
Le TM, Wang W, Zhornitsky S, Dhingra I, Chen Y, Zhang S, Li CR. The Neural Processes Interlinking Social Isolation, Social Support, and Problem Alcohol Use. The International Journal Of Neuropsychopharmacology 2020, 24: 333-343. PMID: 33211853, PMCID: PMC8059487, DOI: 10.1093/ijnp/pyaa086.Peer-Reviewed Original ResearchConceptsSocial supportVentral striatumVS connectivityAlcohol misuseSocial isolationWhole-brain multiple regressionProblem drinkingProblem drinkersAlcohol useResting-state functional magnetic resonanceFunctional magnetic resonanceMiddle frontal gyrusPotential protective factorsProblem alcohol usePrefrontal cortical modulationCognitive controlIndividual differencesNeural processesNeural substratesFrontal gyrusPrefrontal connectivityElevated stress responseFunctional connectivityPath analysisNeural connectivitySex Differences in Neural Responses to the Perception of Social Interactions
Li G, Chen Y, Wang W, Dhingra I, Zhornitsky S, Tang X, Li CR. Sex Differences in Neural Responses to the Perception of Social Interactions. Frontiers In Human Neuroscience 2020, 14: 565132. PMID: 33061901, PMCID: PMC7518190, DOI: 10.3389/fnhum.2020.565132.Peer-Reviewed Original ResearchMiddle frontal gyrusBilateral anterior insulaAnterior insulaSocial interactionHigher activationNeural responsesRight inferior frontal cortexSex differencesPre-supplementary motor areaSocial cognition tasksParacentral lobuleRight superior temporal gyrusWhole-brain regressionInferior frontal cortexSuperior temporal gyrusLower activationMedial orbitofrontal cortexPosterior cingulate cortexHuman Connectome Project dataCognition tasksFacial emotionsNeural processesFrontal gyrusTemporal gyrusSelf-ReportPerceived burdensomeness and neural responses to ostracism in the Cyberball task
Le TM, Zhornitsky S, Wang W, Li CR. Perceived burdensomeness and neural responses to ostracism in the Cyberball task. Journal Of Psychiatric Research 2020, 130: 1-8. PMID: 32763557, PMCID: PMC7554229, DOI: 10.1016/j.jpsychires.2020.06.015.Peer-Reviewed Original ResearchConceptsCyberball taskInterpersonal needsIndividual differencesProsocial behaviorNeural responsesSocial interactionStronger neural responsesGreater brain activationDorsomedial prefrontal cortexMiddle frontal gyrusSocial exclusionResponse timeBrain activationBrain correlatesBehavioral performanceFMRI studyAnterior insulaFrontal gyrusSocial painBehavioral avoidanceAffective responsesBehavioral measuresNeural activationPrefrontal cortexEmotional distressAge-Related Changes in the Neural Processes of Reward-Directed Action and Inhibition of Action
Le TM, Chao H, Levy I, Li CR. Age-Related Changes in the Neural Processes of Reward-Directed Action and Inhibition of Action. Frontiers In Psychology 2020, 11: 1121. PMID: 32587547, PMCID: PMC7298110, DOI: 10.3389/fpsyg.2020.01121.Peer-Reviewed Original ResearchInhibition of actionFunctional brain changesRostral anterior cingulate cortexWhole-brain multiple regressionAnterior cingulate cortexMiddle frontal gyrusAge-related changesFunctional magnetic resonanceBrain changesPostcentral gyrusCingulate cortexAnterior insulaFrontal gyrusTrialsProlonged response timeSuccess trialsGo trialsNeural activationReward-directed actionNegative modulationAgeAction inhibitionBrain substratesAge-related slowingReduced activity
2019
Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex
Le TM, Zhornitsky S, Wang W, Zhang S, Li C. Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex. Addiction Biology 2019, 26: e12857. PMID: 31746092, PMCID: PMC8627684, DOI: 10.1111/adb.12857.Peer-Reviewed Original ResearchConceptsLateral orbitofrontal cortexAlcohol Use Disorders Identification TestGray matter volumeEffect of ProblemOrbitofrontal cortexWhole-brain multiple regressionLeft middle frontal gyrusAlcohol misuseFood cue responsesFunctional magnetic resonance imaging (fMRI) dataVisual food cuesAUDIT scoresMatter volumeMiddle frontal gyrusAffective processesNonfood cuesFood cuesNonfood imagesBrain substratesDisorders Identification TestFrontal gyrusNeural mechanismsFood stimuliCue responsesFood imagesThe effects of age on reward magnitude processing in the monetary incentive delay task
Dhingra I, Zhang S, Zhornitsky S, Le T, Wang W, Chao HH, Levy I, Li CR. The effects of age on reward magnitude processing in the monetary incentive delay task. NeuroImage 2019, 207: 116368. PMID: 31743790, PMCID: PMC7463276, DOI: 10.1016/j.neuroimage.2019.116368.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskSupplementary motor areaMagnitude of rewardAge-related differencesDelay taskRT differencesRegional activationAge effectsEffect of ageReaction time differencesRight anterior insulaMiddle frontal gyrusReward-directed behaviorExplicit cuesMagnitude processingBrain activationRight caudate headAnterior insulaFrontal gyrusReward magnitudeLarge rewardPrimary motor cortexCerebral processesParahippocampal gyrusInterdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Interdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action. Cerebral Cortex 2019, 30: 1662-1676. PMID: 31667492, PMCID: PMC7132903, DOI: 10.1093/cercor/bhz194.Peer-Reviewed Original ResearchConceptsInhibition of actionNeural correlatesReinforcement Sensitivity TheoryRostral anterior cingulate cortexMiddle frontal gyrusAnterior cingulate cortexPunishment sensitivityReinforcement sensitivityMFG activityIndividual differencesNeural processesReward QuestionnaireTrait sensitivityBrain correlatesNeural substratesFrontal gyrusGo responseRewarded actionsSensitivity theoryIncorrect responsesMediation analysisCingulate cortexRegional activationBehavioral approachAvoidance behaviorNeural correlates of enhanced response inhibition in the aftermath of stress
Chang J, Hu J, Li CR, Yu R. Neural correlates of enhanced response inhibition in the aftermath of stress. NeuroImage 2019, 204: 116212. PMID: 31546050, PMCID: PMC7509808, DOI: 10.1016/j.neuroimage.2019.116212.Peer-Reviewed Original ResearchConceptsInhibitory controlAcute stressMagnetic resonance imaging studySignal taskResonance imaging studyFunctional magnetic resonance imaging studyMiddle frontal gyrusTrier Social Stress TestControl conditionSignal reaction timeAftermath of stressSocial Stress TestImaging studiesCognitive functionDynamic causal modelingStress exposureEnhanced response inhibitionPilot studyFrontal gyrusLife stressNeural mechanismsStriatumResponse inhibitionNeural correlatesImmediate effects
2018
Hypothalamic response to cocaine cues and cocaine addiction severity
Zhang S, Zhornitsky S, Angarita GA, Li C. Hypothalamic response to cocaine cues and cocaine addiction severity. Addiction Biology 2018, 25: e12682. PMID: 30295396, PMCID: PMC6453736, DOI: 10.1111/adb.12682.Peer-Reviewed Original ResearchConceptsCocaine Craving QuestionnaireCocaine Selective Severity AssessmentFunctional magnetic resonance imagingCocaine-dependent individualsAddiction severityOrbitofrontal cortexHypothalamic responseVentral striatumCocaine addictionCocaine cuesAngular gyrusBilateral orbitofrontal cortexBilateral visual cortexCue-induced cravingMagnetic resonance imagingMiddle frontal gyrusClinical featuresNeutral cuesDopaminergic circuitsHypothalamusVisual cortexResonance imagingDopaminergic midbrainFrontal gyrusAg responseDiminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients
Li X, Chen H, Lv Y, Chao HH, Gong L, Li CR, Cheng H. Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients. Scientific Reports 2018, 8: 13801. PMID: 30218006, PMCID: PMC6138678, DOI: 10.1038/s41598-018-32257-w.Peer-Reviewed Original ResearchConceptsBreast cancer patientsGray matter densityRight middle frontal gyrusBC patientsCancer patientsCognitive impairmentMiddle frontal gyrusChemotherapy cyclesFrontal gyrusWhole brainGray matterMorphometry analysisHealthy control subjectsStructural magnetic resonance imagingDose-response relationshipMagnetic resonance imagingRight fusiform areaFrontal cortical structuresControl subjectsBilateral cerebellumInferior frontal gyrusPatientsLeft inferior frontal gyrusResonance imagingBrain structures
2016
The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response
Hu S, Ide JS, Zhang S, Li CR. The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response. Journal Of Neuroscience 2016, 36: 12688-12696. PMID: 27974616, PMCID: PMC5157110, DOI: 10.1523/jneurosci.1175-16.2016.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight superior frontal gyrusSuperior frontal gyrusConflict anticipationProactive controlFrontal gyrusImpulsive responsesCognitive controlSignal taskInhibitory controlImpulse controlRegional activationEfficient response inhibitionReaction time differencesMotor urgencyVentromedial prefrontal cortexStop-signal taskYoung adultsSignal reaction timePosterior cingulate cortexIndividual variationError RTAction restraintNeural basisResponse inhibitionCraving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum
Zhang J, Ma S, Li C, Liu L, Xia C, Lan J, Wang L, Liu B, Yao Y, Fang X. Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum. Addiction Biology 2016, 23: 337-346. PMID: 27894158, PMCID: PMC5446940, DOI: 10.1111/adb.12474.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPsychobehavioral interventionsIGD subjectsFunctional connectivityHealthy controlsInternet gaming disorderGreater resting-state functional connectivityFrontal gyrusEffects of CBICross-sectional studyBehavioral intervention studyDirect current stimulationInferior parietal lobuleMiddle frontal gyrusGaming disorderSeverity of IGDInferior frontal gyrusSimilar time intervalsEffective treatmentIntervention studiesNon-invasive techniquePotential biomarkersVentral striatumParietal lobuleCurrent stimulationNovelty Seeking, Harm Avoidance, and Cerebral Responses to Conflict Anticipation: An Exploratory Study
Hu J, Hu S, Maisano JR, Chao HH, Zhang S, Li CR. Novelty Seeking, Harm Avoidance, and Cerebral Responses to Conflict Anticipation: An Exploratory Study. Frontiers In Human Neuroscience 2016, 10: 546. PMID: 27857686, PMCID: PMC5093128, DOI: 10.3389/fnhum.2016.00546.Peer-Reviewed Original ResearchInferior parietal lobuleConflict anticipationProactive controlLateral orbitofrontal cortexMiddle frontal gyrusHarm avoidancePre-supplementary motor areaBilateral inferior parietal lobuleRight inferior parietal lobuleCognitive control circuitsWhole-brain linear regressionTrial reaction timeStop-signal taskRegional brain activationRight lateral orbitofrontal cortexCerebral responsesIndividual differencesSignal taskBrain activationFMRI studyTridimensional Personality QuestionnaireFrontal gyrusGreater activationHA traitExploratory studyHemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait
Kann S, Zhang S, Manza P, Leung HC, Li C. Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait. Brain Connectivity 2016, 6: 724-734. PMID: 27604154, PMCID: PMC5105339, DOI: 10.1089/brain.2016.0443.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior insulaFunctional connectivityLaterality indexDorsomedial prefrontal cortexInferior frontal cortexAutomated Anatomic Labeling (AAL) atlasSuperior parietal lobuleCerebral functional organizationSuperior frontal gyrusPosterior orbital gyrusAttentional orientationAffective processingInsula activationRight lateralizationAffective controlLeft lateralizationSalient stimuliPhysiological arousalTridimensional Personality QuestionnaireFrontal gyrusHemispheric lateralizationSupramarginal gyrusLateralized connectivityParietal lobule