2024
N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia
Tong J, Yang K, Li W, Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Zhao Y, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Tian B, Li C, Hong L, Tan Y. N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia. Schizophrenia Bulletin 2024, sbae180. PMID: 39406395, DOI: 10.1093/schbul/sbae180.Peer-Reviewed Original ResearchFirst-episode schizophreniaSensory gating deficitsN-methyl-D-aspartate receptorsFirst-episode schizophrenia groupGating deficitsN-methyl-D-aspartateP50 ratioSensory gatingExposure to antipsychotic medicationAb levelsHealthy controlsAntipsychotic medication exposureFirst-episode patientsDiagnosis of schizophreniaImpaired sensory gatingP50 sensory gating deficitN-methyl-D-aspartate receptor antibodiesAntipsychotic medicationFirst-episodeNon-smoking healthy controlsP50 differenceSchizophreniaPartial correlation analysisEnzyme-linked immunosorbent assayDeficits
2022
Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis
Zhornitsky S, Tourjman V, Pelletier J, Assaf R, Li CR, Potvin S. Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2022, 118: 110575. PMID: 35568275, DOI: 10.1016/j.pnpbp.2022.110575.Peer-Reviewed Original ResearchConceptsVerbal learningCognitive domainsResponse inhibitionAcute ketamine administrationVerbal learning/memorySpeed of processingLearning/memorySocial cognitionVerbal memoryExecutive functionVisual learningVisuospatial abilitiesMemory figuresCognitionMemoryCognitive impairmentAcute ketamineKetamine administrationEffect sizeLearningImpairmentModerate impairmentDeficitsNegative effectsHealthy individualsEmotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. American Journal Of Alzheimer's Disease & Other Dementias® 2022, 37: 15333175221082834. PMID: 35357236, PMCID: PMC9212074, DOI: 10.1177/15333175221082834.Peer-Reviewed Original ResearchConceptsEmotional processing deficitsProcessing dysfunctionProcessing deficitsMultiple behavioral paradigmsEmotional memoryEmotional stimuliPositive emotionsAltered emotionsNegative emotionsNeural correlatesEmotional processing dysfunctionAmygdala reactivityBehavioral findingsEmotional disordersCognitive deficitsBehavioral paradigmsProminent deficitsEmotionsAlzheimer's diseaseBehavioral studiesLongitudinal studyNoradrenergic signalingDeficitsCircuit dysfunctionMemory
2020
Acute effects of partial CB1 receptor agonists on cognition – A meta-analysis of human studies
Zhornitsky S, Pelletier J, Assaf R, Giroux S, Li CR, Potvin S. Acute effects of partial CB1 receptor agonists on cognition – A meta-analysis of human studies. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2020, 104: 110063. PMID: 32791166, DOI: 10.1016/j.pnpbp.2020.110063.Peer-Reviewed Original ResearchConceptsVerbal learning/memorySpeed of processingLearning/memoryCognitive domainsResidual cognitive effectsChronic cannabis usersAcute cannabis consumptionExecutive functionCognitive effectsCannabis usersImpulsivityEffect size estimatesMemoryCognitive dysfunctionCannabis consumptionCognitionCB1 receptor agonistDeficitsModerate impairmentProcessingAnalysis of routesImpairmentIntravenous administration studyComprehensive Meta-AnalysisNegative effects
2004
A Psychophysical Measure of Attention Deficit in Children With Attention-Deficit/Hyperactivity Disorder
Li CS, Lin WH, Chang HL, Hung YW. A Psychophysical Measure of Attention Deficit in Children With Attention-Deficit/Hyperactivity Disorder. Journal Of Psychopathology And Clinical Science 2004, 113: 228-236. PMID: 15122943, DOI: 10.1037/0021-843x.113.2.228.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderADHD childrenAttention deficitsHyperactivity disorderRapid serial visual presentation taskVisual presentation taskSignal detection theoryClose temporal proximitySecond control experimentAttentional blinkPresentation taskAttention impairmentDetection theoryPsychophysical measuresTemporal proximityAttention gateTemporal mechanismsBlinkChildrenDeficitsImpairmentDistractorsDisordersTaskParticipants
2002
Impaired detection of visual motion in schizophrenia patients
Li CS. Impaired detection of visual motion in schizophrenia patients. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2002, 26: 929-934. PMID: 12369268, DOI: 10.1016/s0278-5846(02)00207-5.Peer-Reviewed Original ResearchConceptsSchizophrenia patientsNormal controlsNormal subjectsPatientsSignal detection theorySimilar deficitsImpaired detectionCore deficitAttention impairmentMotion stimuliSensory modalitiesVisual tasksResponse biasVisual motionRecent reportsAuditory detectionDetection theoryTrialsDeficitsRandom dotsPsychometric functionsSignal intensitySensitivity variesGroupCoherent direction