2023
The effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition
Li G, Zhang Z, Zhang Y, Tang X, Li C. The effects of cocaine use severity and abstinence on behavioral performance and neural processes of response inhibition. Psychiatry Research Neuroimaging 2023, 336: 111734. PMID: 37871409, DOI: 10.1016/j.pscychresns.2023.111734.Peer-Reviewed Original ResearchConceptsDays of abstinenceStop-signal reaction timeHealthy controlsCocaine dependenceSuperior temporal gyrusCocaine use severityStop-signal taskCocaine useResponse inhibitionUse severityBilateral superior temporal gyrusFunctional magnetic resonanceWhole-brain regressionNeural processesPoor response inhibitionInhibition dysfunctionCerebral markersTemporal gyrusSTG activityAbstinenceSuccess trialsSeverityNeural mechanismsInhibitionBehavioral performance
2020
Interpersonal Risk Factors for Suicide in Cocaine Dependence: Association with Self‐Esteem, Personality Traits, and Childhood Abuse
Zhornitsky S, Le TM, Dhingra I, Adkinson BD, Potvin S, Li C. Interpersonal Risk Factors for Suicide in Cocaine Dependence: Association with Self‐Esteem, Personality Traits, and Childhood Abuse. Suicide And Life-Threatening Behavior 2020, 50: 867-883. PMID: 32030810, PMCID: PMC7518050, DOI: 10.1111/sltb.12621.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsHarm avoidanceChildhood abusePersonality traitsSexual abuseCocaine dependenceGreater emotional abuseLow harm avoidanceInterpersonal risk factorsElevated harm avoidancePredictors of PbLack of belongingnessInterpersonal theoryNovelty seekingEmotional abuseSelf-EsteemHealthy controlsGroup differencesPhysical abuseSubstance useAbuseSuicidal behaviorAvoidanceDepressionSex analysis
2018
Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study
Zhang S, Wang W, Zhornitsky S, Li CR. Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study. Frontiers In Psychiatry 2018, 9: 344. PMID: 30100886, PMCID: PMC6072838, DOI: 10.3389/fpsyt.2018.00344.Peer-Reviewed Original ResearchState functional connectivityMedial hypothalamusHealthy controlsCocaine dependenceDorsolateral prefrontal cortexFunctional connectivityHypothalamic connectivityPrefrontal cortexVentral striatumCocaine misuseConnectivity strengthCocaine Craving QuestionnaireRole of dopamineInferior parietal lobuleLateral hypothalamusTrend-level significanceMesocorticolimbic circuitPreclinical workHypothalamusVentromedial prefrontal cortexCocaine usePast monthParietal lobuleTemporal gyrusHypothalamus functionsVentral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity
Zhang S, Li CR. Ventral striatal dysfunction in cocaine dependence – difference mapping for subregional resting state functional connectivity. Translational Psychiatry 2018, 8: 119. PMID: 29915214, PMCID: PMC6006289, DOI: 10.1038/s41398-018-0164-0.Peer-Reviewed Original ResearchConceptsState functional connectivityCocaine dependenceVentral striatumFunctional connectivityVentral striatal dysfunctionExtent of depressionCircuit deficitsDopaminergic deficitFunctional dysconnectivityStriatal dysfunctionRSFC differencesVmPFC connectivitySubregional changesRsFC changesParahippocampal gyrusCocaine cravingCortical connectivityHealthy populationVentromedial prefrontal cortexVisual cortexMental illnessCocaine useRSFCPrefrontal cortexFunctional subregions
2017
Classification of Cocaine Dependents from fMRI Data Using Cluster-Based Stratification and Deep Learning
Santos J, Savii R, Ide J, Li C, Quiles M, Basgalupp M. Classification of Cocaine Dependents from fMRI Data Using Cluster-Based Stratification and Deep Learning. Lecture Notes In Computer Science 2017, 10404: 298-313. DOI: 10.1007/978-3-319-62392-4_22.Peer-Reviewed Original ResearchDeep learningDeep learning methodsDeep neural networksDeep belief networkSmall data setsComputational visionClassification of pathologiesBelief networkFMRI classificationVoice recognitionNeural networkLearning methodsRobust trainingBrain decodingSmall dataData setsLearningCocaine dependenceNovel stratification methodTraditional techniquesNetworkClassificationCocaine dependentsNon-addicted individualsDrug use
2016
Power spectrum scale invariance as a neural marker of cocaine misuse and altered cognitive control
Ide JS, Hu S, Zhang S, Mujica-Parodi LR, Li CS. Power spectrum scale invariance as a neural marker of cocaine misuse and altered cognitive control. NeuroImage Clinical 2016, 11: 349-356. PMID: 27294029, PMCID: PMC4888196, DOI: 10.1016/j.nicl.2016.03.004.Peer-Reviewed Original ResearchConceptsPower spectrum scale invarianceCognitive controlInferior frontal gyrusNeural markersBehavioral adjustmentSupramarginal gyrusLeft inferior frontal gyrusFunctional magnetic resonance imagingFronto-parietal areasBlood oxygenation level-dependent (BOLD) signalCocaine misuseLevel-dependent signalCocaine-dependent adultsSignal taskFrontal gyrusFrontoparietal regionsPrefrontal cortexMagnetic resonance imagingConnectivity dynamicsBehavioral variablesCerebral activityCocaine addictionCocaine exposureCocaine dependenceDependent adults
2014
Error-related functional connectivity of the thalamus in cocaine dependence
Zhang S, Hu S, Bednarski SR, Erdman E, Li CS. Error-related functional connectivity of the thalamus in cocaine dependence. NeuroImage Clinical 2014, 4: 585-592. PMID: 24936409, PMCID: PMC4053644, DOI: 10.1016/j.nicl.2014.01.015.Peer-Reviewed Original ResearchConceptsVentral medial prefrontal cortexFunctional connectivityCognitive controlGeneralized psychophysiological interaction analysisTask-related processesPsychophysiological interaction analysisSubgenual anterior cingulate cortexCocaine dependenceMedial prefrontal cortexAnterior cingulate cortexError processingExecutive functionCocaine-dependent patientsPrefrontal cortexCingulate cortexRelated activationSubstance misuseCocaine useDrug useThalamic connectivity
2013
Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCerebral CortexCocaine-Related DisordersCognition DisordersFemaleHumansImage Processing, Computer-AssistedInhibition, PsychologicalMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedModels, NeurologicalNeural PathwaysNeuropsychological TestsOxygenPhotic StimulationReaction TimeConceptsFunctional magnetic resonance imagingStop-signal taskCD individualsCerebral activationPrecuneus/posterior cingulate cortexSystolic blood pressureInfluence of methylphenidateEffects of methylphenidateMagnetic resonance imagingPosterior cingulate cortexBrain imaging studiesCocaine-addicted individualsDefault mode networkAgonist therapyBlood pressureIntravenous methylphenidateCortico-striatoHealthy controlsCocaine-dependent individualsThalamic activationCingulate cortexResonance imagingBrain regionsMethylphenidateCocaine dependenceError processing and gender-shared and -specific neural predictors of relapse in cocaine dependence
Luo X, Zhang S, Hu S, Bednarski SR, Erdman E, Farr OM, Hong KI, Sinha R, Mazure CM, Li CS. Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence. Brain 2013, 136: 1231-1244. PMID: 23485852, PMCID: PMC3613717, DOI: 10.1093/brain/awt040.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexFunctional magnetic resonance imagingCognitive controlError-related activationError processingCocaine-dependent individualsAnterior cingulate cortexSignal taskCingulate cortexCocaine dependenceFunctional magnetic resonance imaging (fMRI) dataStop-signal taskTreatment-seeking individualsCross-sectional findingsModerate-sized cohortsBrain activationBehavioral treatmentNeural predictorsDrug useMagnetic resonance imaging dataStatistical Parametric Mapping 8Regional activationPsychosocial factorsSuccess trialsMagnetic resonance imaging
2011
Deficits in default mode network activity preceding error in cocaine dependent individuals
Bednarski SR, Zhang S, Hong KI, Sinha R, Rounsaville BJ, Li CS. Deficits in default mode network activity preceding error in cocaine dependent individuals. Drug And Alcohol Dependence 2011, 119: e51-e57. PMID: 21703783, PMCID: PMC3188675, DOI: 10.1016/j.drugalcdep.2011.05.026.Peer-Reviewed Original ResearchConceptsDefault mode networkCocaine dependenceCocaine useHealthy controlsTask-related cerebral activationBlood oxygenation level-dependent (BOLD) signalDemographics-matched healthy controlsGray matter volumeDefault mode network activityLevel-dependent signalChronic cocaine useRegional brain activationPosterior cingulate cortexStatistical parametric mappingCerebral functionBilateral precuneusCocaine-dependent individualsCerebral activationHealthy peopleMatter volumeCingulate cortexVentromedial prefrontal cortexBrain regionsCognitive deficitsCocaine misuse
2010
Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
Li CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14455-14459. PMID: 20660731, PMCID: PMC2922598, DOI: 10.1073/pnas.1002467107.Peer-Reviewed Original ResearchConceptsMiddle frontal cortexStop-signal reaction timeCocaine-dependent patientsWhole-brain linear regressionLonger stop-signal reaction timesFunctional MRI studyInhibitory controlInhibition-related activationBlood pressureIntravenous methylphenidatePeripheral biomarkersSignal reaction timeFrontal cortexStop-signal taskIndividualized treatmentHealthy individualsMRI studiesVentromedial prefrontal cortexSpecific neural mechanismsCocaine dependenceBiological markersPrefrontal cortexPatientsMethylphenidate responseSignal task
2007
Neural Correlates of Impulse Control During Stop Signal Inhibition in Cocaine-Dependent Men
Li CS, Huang C, Yan P, Bhagwagar Z, Milivojevic V, Sinha R. Neural Correlates of Impulse Control During Stop Signal Inhibition in Cocaine-Dependent Men. Neuropsychopharmacology 2007, 33: 1798-1806. PMID: 17895916, PMCID: PMC2731999, DOI: 10.1038/sj.npp.1301568.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexCocaine-dependent menFunctional magnetic resonance imagingCocaine dependenceResponse inhibitionNeural correlatesHealthy control subjectsRisk of relapsePre-supplementary motor areaSubstance use disordersAnterior cingulate cortexImpulse controlSignal inhibitionMagnetic resonance imagingUseful neural markersStop-signal inhibitionRelative hypoactivationMale patientsControl subjectsSignal reaction timeMotor areaYears of educationUse disordersCingulate cortexResonance imaging
2006
Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence
Li CS, Milivojevic V, Kemp K, Hong K, Sinha R. Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. Drug And Alcohol Dependence 2006, 85: 205-212. PMID: 16725282, DOI: 10.1016/j.drugalcdep.2006.04.008.Peer-Reviewed Original ResearchConceptsImpaired response inhibitionStop-signal taskResponse inhibitionCognitive processesCocaine-dependent patientsSignal taskResponse readinessTask-related cognitive processesCritical cognitive mechanismsPerformance monitoringMeasures of impulsivityEducation-matched healthy controlsSignal reaction timeAbstinent cocaine-dependent patientsHorse-race modelCognitive mechanismsPSS effectCocaine subjectsRace modelHealthy controlsSubstance abusersAbstinent patientsSSRTStop signalCocaine dependence