2024
Androgen deprivation increases frontopolar cortical thickness in prostate cancer patients: an effect of early neurodegeneration?
Chaudhary S, Roy A, Summers C, Ahles T, Li C, Chao H. Androgen deprivation increases frontopolar cortical thickness in prostate cancer patients: an effect of early neurodegeneration? American Journal Of Cancer Research 2024, 14: 3652-3664. PMID: 39113873, PMCID: PMC11301281, DOI: 10.62347/wola8904.Peer-Reviewed Original ResearchFrontopolar cortexCortical thicknessWorking memoryAndrogen deprivation therapyN-back performanceN-back taskProstate cancer patientsYears of educationPublished routinesNeural consequencesBrain changesBrain morphologyMediation analysisCT changesConsequences of androgen deprivation therapyMonths of androgen deprivation therapyTestosterone level changesImpact of androgen deprivation therapyCancer patientsNon-metastatic prostate cancerTestosterone levelsResponse to androgen deprivationLong duration of treatmentBrain imagingNeurodegenerative changes
2022
Effects of androgen deprivation on white matter integrity and processing speed in prostate cancer patients.
Chaudhary S, Roy A, Summers C, Ahles T, Li C, Chao H. Effects of androgen deprivation on white matter integrity and processing speed in prostate cancer patients. American Journal Of Cancer Research 2022, 12: 4802-4814. PMID: 36381311, PMCID: PMC9641391.Peer-Reviewed Original ResearchAndrogen deprivation therapyProstate cancer patientsWhite matter integrityCancer patientsAndrogen deprivationFractional anisotropyNon-metastatic prostate cancerSignificant FA changesImpaired white matter integrityPosterior corona radiataAnterior thalamic radiationDiffusion tensor imagingADT patientsDeprivation therapyProspective studyCorpus callosumProstate cancerCorona radiataYears of educationThalamic radiationPatientsWhole brainCognitive deficitsCognitive functionTensor imagingHypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients
Chaudhary S, Roy A, Summers C, Zhornitsky S, Ahles T, Li CR, Chao HH. Hypothalamic connectivities predict individual differences in ADT-elicited changes in working memory and quality of life in prostate cancer patients. Scientific Reports 2022, 12: 9567. PMID: 35688928, PMCID: PMC9187668, DOI: 10.1038/s41598-022-13361-4.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsQuality of lifeCancer patientsCorrect response rateMonths of ADTLong-term androgen deprivation therapyResponse rateNon-metastatic prostate cancerMontreal Cognitive Assessment scoreProspective observational studyState functional connectivityCognitive Assessment scoreDeprivation therapyHypothalamic connectivityAndrogen deprivationPrognostic markerProstate cancerGonadal axisObservational studyYears of educationQOL effectsControl groupQoLSalience networkThe effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity
Chaudhary S, Zhornitsky S, Roy A, Summers C, Ahles T, Li C, Chao HH. The effects of androgen deprivation on working memory and quality of life in prostate cancer patients: The roles of hypothalamic connectivity. Cancer Medicine 2022, 11: 3425-3436. PMID: 35315585, PMCID: PMC9487881, DOI: 10.1002/cam4.4704.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyMid-cingulate cortexEffects of ADTFunctional connectivityPrecentral gyrusN-back taskN-back performanceState functional connectivityMontreal Cognitive Assessment scoreHypothalamic functional connectivityProspective observational studyNonmetastatic prostate cancerProstate cancer patientsCognitive Assessment scoreQuality of lifeSustain attentionAffective functionsDeprivation therapyHypothalamic connectivityYears of educationAndrogen deprivationCorrect response rateQOL scoresCancer patientsClinical correlates
2020
Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression
Li W, Zhao J, Ding K, Chao HH, Li CR, Cheng H, Shen L. Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression. Medical Science Monitor 2020, 26: e923567-1-e923567-10. PMID: 32985495, PMCID: PMC7531203, DOI: 10.12659/msm.923567.Peer-Reviewed Original ResearchConceptsBreast cancer patientsHormonal receptor expressionCancer patientsReceptor expressionMemory impairmentProgesterone receptorBreast cancerEstrogen receptorG genotypeGene polymorphismsCognitive impairmentRisks of chemotherapyBreast cancer survivorsSingle nucleotide polymorphismsProspective memory impairmentCatechol-O-methyltransferase gene polymorphismExtent of deficitsMemory scoresER-/PRBDNF polymorphismCancer survivorsCognitive dysfunctionChemotherapyPatientsCognitive deficits
2019
The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression.
Chen H, Ding K, Zhao J, Chao HH, Li CR, Cheng H. The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression. American Journal Of Cancer Research 2019, 9: 1776-1785. PMID: 31497358, PMCID: PMC6726991.Peer-Reviewed Original ResearchChemotherapy-related cognitive impairmentBreast cancer patientsHormone receptor expressionDorsolateral prefrontal cortexLeft dorsolateral prefrontal cortexCancer patientsSuperior frontal gyrusReceptor expressionFunctional connectivityPrefrontal cortexEstrogen receptorLeft precuneusCognitive impairmentFunctional magnetic resonance imaging (fMRI) examinationsMagnetic resonance imaging examinationsRight superior frontal gyrusNeuropsychological testsRight dorsolateral prefrontal cortexFunctional connectivity strengthResting-state fMRI dataER-/PRBC patientsDLPFC connectivityBreast cancerImaging examinationsDepression involved in self-reported prospective memory problems in survivors of breast cancer who have received chemotherapy
Huang Z, Zhao J, Ding K, Lv Y, Zhang C, Chao HH, Li CS, Cheng H. Depression involved in self-reported prospective memory problems in survivors of breast cancer who have received chemotherapy. Medicine 2019, 98: e15301. PMID: 31008981, PMCID: PMC6494378, DOI: 10.1097/md.0000000000015301.Peer-Reviewed Original ResearchConceptsSelf-rating Depression ScaleBreast cancer survivorsBreast cancer patientsCancer survivorsCancer patientsExtensive neuropsychological assessmentSignificant differencesMemory problemsBreast cancerDepression ScaleChemotherapyDepression groupPatientsNeuropsychological assessmentLevel of significanceSurvivorsDepressionScoresSPM scoresMemory QuestionnaireProspective memory problemsGroupPresent resultsCancerNeural correlates of chemotherapy-induced emotion regulation impairment in breast cancer patients.
Gan C, Lv Y, Zhao J, Chao HH, Li CR, Zhang C, Yu F, Cheng H. Neural correlates of chemotherapy-induced emotion regulation impairment in breast cancer patients. American Journal Of Cancer Research 2019, 9: 171-179. PMID: 30755820, PMCID: PMC6356929.Peer-Reviewed Original Research
2018
Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer
Cheng H, Chen H, Lv Y, Chen Z, Li C. Prospective memory impairment following whole brain radiotherapy in patients with metastatic brain cancer. Cancer Medicine 2018, 7: 5315-5321. PMID: 30259694, PMCID: PMC6198199, DOI: 10.1002/cam4.1784.Peer-Reviewed Original ResearchConceptsDigit span testVerbal fluency testProspective memory impairmentMini-Mental State ExaminationTime-based prospective memory taskMemory impairmentProspective memory taskCognitive neuropsychological testsWhole brain radiotherapyMetastatic brain cancerMemory taskSpan testFluency testNeuropsychological testsBrain cancerState ExaminationBrain metastasesBrain radiotherapyCancer patientsImpairmentNonsignificant decreasePatientsTBPMRadiotherapyTaskDiminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients
Li X, Chen H, Lv Y, Chao HH, Gong L, Li CR, Cheng H. Diminished gray matter density mediates chemotherapy dosage-related cognitive impairment in breast cancer patients. Scientific Reports 2018, 8: 13801. PMID: 30218006, PMCID: PMC6138678, DOI: 10.1038/s41598-018-32257-w.Peer-Reviewed Original ResearchConceptsBreast cancer patientsGray matter densityRight middle frontal gyrusBC patientsCancer patientsCognitive impairmentMiddle frontal gyrusChemotherapy cyclesFrontal gyrusWhole brainGray matterMorphometry analysisHealthy control subjectsStructural magnetic resonance imagingDose-response relationshipMagnetic resonance imagingRight fusiform areaFrontal cortical structuresControl subjectsBilateral cerebellumInferior frontal gyrusPatientsLeft inferior frontal gyrusResonance imagingBrain structures
2013
Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study
Chao HH, Hu S, Ide JS, Uchio E, Zhang S, Rose M, Concato J, Li CS. Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study. PLOS ONE 2013, 8: e72032. PMID: 23977199, PMCID: PMC3747074, DOI: 10.1371/journal.pone.0072032.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsGray matter volumeMagnetic resonance imagingPrimary motor cortexCancer patientsVoxel-based morphometryMatter volumeMotor cortexProstate cancerEffects of ADTLow-risk prostate cancerCerebral gray matter volumeStatistical Parametric Mapping 8Utility of brainControl participantsHigh-resolution magnetic resonance imagingPotential side effectsQuality of lifeResolution magnetic resonance imagingSame time pointsFunctional magnetic resonance imagingHigh-resolution T1Prefrontal cortical activationDorsolateral prefrontal cortex