2024
Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunction
2023
Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential ageAge-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing
Chaudhary S, Zhang S, Zhornitsky S, Chen Y, Chao H, Li C. Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing. NeuroImage 2023, 276: 120207. PMID: 37263454, PMCID: PMC10330646, DOI: 10.1016/j.neuroimage.2023.120207.Peer-Reviewed Original ResearchConceptsFaster reaction timesNegative emotionsAge-related declineEmotional stimuliTrait anxietyAge-related reductionReaction timeEmotion regulation literatureSalient emotional stimuliPositive emotional stimuliFacial emotion processingPrefrontal cortical responsesRostral anterior cingulate cortexWhole-brain regressionAnterior cingulate activityDefault mode networkAnterior cingulate cortexEmotion regulationNeural evidenceEmotion processingDorsolateral PFCStimulus registrationDiminished anxietyPsychophysiological interactionEmotional circuits