Charles Sun Dela Cruz MD, PhD

Assistant Professor of Medicine (Pulmonary)

Departments & Organizations

Yale Medical Group

Office of Student ResearchInternal Medicine: Pulmonary, Critical Care & Sleep Medicine: Dela Cruz Lab

Research Interests

Pathogenesis of COPD and Emphysema; Viral and Bacterial Lung Infections in the Pathogenesis of Lung Diseases; Chitinases and Chitinase-Like Proteins in Pulmonary Infections; Role of Interleukin-15 in the Lung more...


  • B.S., University of Toronto, 1994
  • Ph.D., University of Toronto, 2000
  • M.D., Yale University School of Medicine, 2003

Selected Publications

  • Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA. Chitinase 3-like-1 (Chi3l1) regulation of Streptococcus pneumoniae lung infection. 2012. Cell Host and Microbe, 12:23-46.
  • Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. 2011. RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Am J Respir Crit Care Med, 183(10):1322-35
  • Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG. 2011. Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema. Am J Respir Cell Mol Biol, 44(6):777-86.



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