Wei Zheng
Associate Research ScientistAbout
Research
Publications
2025
Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study
Ugalde-Morales E, Wilf R, Pluta J, Ploner A, Fan M, Damra M, Aben K, Anson-Cartwright L, Chen C, Cortessis V, Daneshmand S, Ferlin A, Gamulin M, Gietema J, Gonzalez-Niera A, Grotmol T, Hamilton R, Harland M, Haugen T, Hauser R, Hildebrandt M, Karlsson R, Kiemeney L, Kim J, Lessel D, Lothe R, Loveday C, Chanock S, McGlynn K, Meijer C, Nead K, Nsengimana J, Popovic M, Rafnar T, Richiardi L, Rocca M, Schwartz S, Skotheim R, Stefansson K, Stewart D, Turnbull C, Vaughn D, Winge S, Zheng T, Monteiro A, Almstrup K, Kanetsky P, Nathanson K, Wiklund F, Consortium T. Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study. American Journal Of Human Genetics 2025, 112: 630-643. PMID: 39999848, PMCID: PMC11947167, DOI: 10.1016/j.ajhg.2025.01.022.Peer-Reviewed Original ResearchConceptsTranscriptome-wide association studyGenome-wide association studiesAssociation studiesTesticular germ cell tumorsTranscriptome-wide association study signalsGenome-wide association study lociTesticular germ cell tumour susceptibilityTesticular germ cell tumor tissuesFine-mapping analysisGene-disease linksGonadal cell typesEvidence of colocalizationProtein levels accumulationExpression levelsTesticular germ cell tumour riskPrioritized genesFalse discovery rateNeighboring genesGene-diseaseRegulatory featuresGene associationsColocalization analysisProtein patternsGenesNormal testis
2024
Exposure to per- and poly-fluoroalkyl substances and lung, head and neck, and thyroid cancer: A systematic review and meta-analysis
Sassano M, Seyyedsalehi M, Kappil E, Zhang S, Zheng T, Boffetta P. Exposure to per- and poly-fluoroalkyl substances and lung, head and neck, and thyroid cancer: A systematic review and meta-analysis. Environmental Research 2024, 266: 120606. PMID: 39672496, DOI: 10.1016/j.envres.2024.120606.Peer-Reviewed Original ResearchPooled relative riskRelative riskHead and neckEstimate pooled relative risksConfidence intervalsExposure to per-Evidence of publication biasNatural log-unit increaseThyroid cancerCase-control studyPolyfluoroalkyl substances exposuresAssociated with lungPublication biasSystematic reviewPositive associationMeasured serum levelsMeta-analysisSerum PFAS levelsTesticular cancerProspective studyAssociationSerum levelsPFAS exposureExposure assessmentLung cancerPer- and poly-fluoroalkyl substances exposure and risk of gastrointestinal cancers: a systematic review and meta-analysis.
Zhang S, Kappil E, Zheng T, Boffetta P, Seyyedsalehi M. Per- and poly-fluoroalkyl substances exposure and risk of gastrointestinal cancers: a systematic review and meta-analysis. European Journal Of Cancer Prevention 2024 PMID: 39648934, DOI: 10.1097/cej.0000000000000935.Peer-Reviewed Original ResearchPFAS exposureStratified analysisMeta-analysisRisk of gastrointestinal cancerSystematic reviewGastrointestinal cancerModified Newcastle-Ottawa ScaleInternational Agency for Research on Cancer MonographsNewcastle-Ottawa ScaleSystematic review of literatureDose-response trendRandom-effects modelPancreatic cancerPotential confoundersIndependent reviewersYear of publicationPublication biasStudy designMeta-analysesColorectal cancerGastric cancerQuality scoresColorectalSubstance exposurePoly-fluoroalkyl substancesThe fetal origins of metabolic health: exploring the association between newborn biological age and metabolism hormones in childhood
Jia Z, Qiu F, He Y, Chen H, Yang C, Liu H, Zheng T, Xu S, Wang S, Li Y. The fetal origins of metabolic health: exploring the association between newborn biological age and metabolism hormones in childhood. BMC Medicine 2024, 22: 429. PMID: 39379967, PMCID: PMC11462715, DOI: 10.1186/s12916-024-03629-z.Peer-Reviewed Original ResearchConceptsRestricted cubic splinesLeptin levelsMetabolic hormonesMetabolic healthDNA methylationRestricted cubic spline analysisProspective birth cohort studyDNA methylation ageMother-child pairsBirth cohort studyDNA copy numberFetal originMitochondrial DNA copy numberResultsThe linear regression analysisReal-time PCRCohort studyHorvath's epigenetic clockInsulin levelsInverse associationLeptinQuantitative real-time PCRInfinium MethylationEPIC BeadChipElectrochemiluminescence assayLinear regression analysisMetabolic statusDiabetes risk reduction diet and risk of liver cancer and chronic liver disease mortality: A prospective cohort study
Chen Y, Zhao L, Jung S, Pichardo M, Lopez‐Pentecost M, Rohan T, Saquib N, Sun Y, Tabung F, Zheng T, Wactawski‐Wende J, Manson J, Neuhouser M, Zhang X. Diabetes risk reduction diet and risk of liver cancer and chronic liver disease mortality: A prospective cohort study. Journal Of Internal Medicine 2024, 296: 410-421. PMID: 39239793, DOI: 10.1111/joim.20007.Peer-Reviewed Original ResearchChronic liver disease mortalityDiabetes risk reduction dietLiver disease mortalitySugar-sweetened beveragesDRRD scoreFood-frequency questionnaireDisease mortalityFood-frequencyIncident liver cancer casesChronic liver disease deathsWomen's Health Initiative-Observational StudyHazard ratioRisk of liver cancerLiver disease deathsTrans fatConfidence intervalsMultivariable hazard ratiosAssociated with reduced riskLiver cancer incidencePostmenopausal womenLiver cancerIntake of dietary fiberCox proportional hazards regression modelsProspective cohort studyRisk of liver cancer developmentDiabetes Risk Reduction Diet and Risk of Liver Cancer and Chronic Liver Disease Mortality: A Prospective Cohort Study
Chen Y, Zhao L, Jung S, Pichardo M, Lopez-Pentecost M, Rohan T, Saquib N, Sun Y, Tabung F, Zheng T, Wactawski-Wende J, Manson J, Neuhouser M, Zhang X. Diabetes Risk Reduction Diet and Risk of Liver Cancer and Chronic Liver Disease Mortality: A Prospective Cohort Study. Current Developments In Nutrition 2024, 8: 102547. DOI: 10.1016/j.cdnut.2024.102547.Peer-Reviewed Original ResearchIntrauterine chromium exposure and cognitive developmental delay: The modifying effect of genetic predisposition
Jia Z, Zhang H, Lv Y, Yu L, Cui Y, Zhang L, Yang C, Liu H, Zheng T, Xia W, Xu S, Li Y. Intrauterine chromium exposure and cognitive developmental delay: The modifying effect of genetic predisposition. The Science Of The Total Environment 2024, 946: 174350. PMID: 38960203, DOI: 10.1016/j.scitotenv.2024.174350.Peer-Reviewed Original ResearchRisk due to interactionCognitive developmental delayGenetic riskSynergy indexGenetic factorsExcess risk due to interactionDevelopmental delayBayley Scales of Infant DevelopmentProportion due to interactionPolygenic risk scoresHigh-risk factorsEffects of genetic predispositionDose-response relationshipMother-child pairsGenetic backgroundBayley ScalesGenetic predispositionIncreased riskRisk scoreCr exposureLogistic regressionInfant developmentPlasma Cr concentrationIntrauterineAdditive interactionPrenatal arsenic metabolite exposure is associated with increased newborn mitochondrial DNA copy number: evidence from a birth cohort study
Qiu F, Zhang H, Wang X, Jia Z, He Y, Wu Y, Li Z, Zheng T, Xia W, Xu S, Li Y. Prenatal arsenic metabolite exposure is associated with increased newborn mitochondrial DNA copy number: evidence from a birth cohort study. Environmental Science And Pollution Research 2024, 31: 38142-38152. PMID: 38789711, DOI: 10.1007/s11356-024-32933-7.Peer-Reviewed Original ResearchDNA copy numberThird trimesterUrinary arsenic species concentrationsNewborn mitochondrial DNA copy numberMother-newborn pairsDose-response trendMitochondria DNA copy numberReal-time polymerase chain reactionBirth cohort studyMetabolite exposureCopy numberMitochondrial DNA copy numberOne-unit incrementCovariate-adjusted modelsBlood mtDNAcnQuantitative real-time polymerase chain reactionPolymerase chain reactionCohort studyTrimesterMetabolite levelsPotential associationStatistical significanceArsenic metabolitesChain reactionMtDNAcnCorrigendum to “Urinary biomarkers of exposure to organophosphate, pyrethroid, neonicotinoid insecticides and oxidative stress: A repeated measurement analysis among pregnant women” [Sci. Total Environ. volume 912, 2024, 169565]
Wang A, Wan Y, Qi W, Mahai G, Qian X, Zheng T, Li Y, Xu S, Xiao H, Xia W. Corrigendum to “Urinary biomarkers of exposure to organophosphate, pyrethroid, neonicotinoid insecticides and oxidative stress: A repeated measurement analysis among pregnant women” [Sci. Total Environ. volume 912, 2024, 169565]. The Science Of The Total Environment 2024, 926: 172178. PMID: 38582708, DOI: 10.1016/j.scitotenv.2024.172178.Peer-Reviewed Original ResearchPer- And Poly-Fluoroalkyl Substances (PFAS) Exposure and Risk of Breast, and Female Genital Cancers: A Systematic Review and Meta-Analysis
Seyyedsalehi M, Kappil E, Zhang S, Zheng T, Boffetta P. Per- And Poly-Fluoroalkyl Substances (PFAS) Exposure and Risk of Breast, and Female Genital Cancers: A Systematic Review and Meta-Analysis. La Medicina Del Lavoro 2024, 115: e2024043. PMID: 39697081, PMCID: PMC11734636, DOI: 10.23749/mdl.v115i6.16330.Peer-Reviewed Original ResearchConceptsRisk of breastFemale genital cancersPFAS exposureRelative riskStratified analysisCase-controlRisk of breast cancerMeta-analysisStudy designBreast cancer incidenceGenital cancersQuality of studiesBreast cancerPublication bias evaluationRandom-effects modelCancer incidenceEcological studiesOvarian cancerYear of publicationPublication biasData extractionSystematic reviewMeta-analysesDose-response relationshipPotential bias
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