Woo Sub Yang
Associate Research Scientist in GeneticsAbout
Research
Publications
2025
Hemodynamics of slip surfaces for thrombosis control in implanted cardiovascular devices
Choi K, Yang W, Pak O, Seo J. Hemodynamics of slip surfaces for thrombosis control in implanted cardiovascular devices. Physics Of Fluids 2025, 37: 021907. DOI: 10.1063/5.0250947.Peer-Reviewed Original ResearchWall shear stressSlip surfaceEffects of slip surfacesLow wall shear stressStent modelComputational fluid dynamicsPercutaneous medical devicesSlip boundary conditionCoronary artery modelShear stressFluid dynamicsSimulation resultsResidence timeImplantable cardiovascular devicesCardiovascular devicesSlipBoundary conditionsArtery modelMedical devicesDevice lifespanVessel wallDevicesSurfacePacemaker modelWallSynergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
Coquel F, Ho S, Tsai K, Yang C, Aze A, Devin J, Chang T, Kong-Hap M, Bioteau A, Moreaux J, Maiorano D, Pourquier P, Yang W, Lin Y, Pasero P. Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth. ELife 2025, 13: rp104718. PMID: 39887032, PMCID: PMC11785374, DOI: 10.7554/elife.104718.Peer-Reviewed Original ResearchConceptsCancer cellsVulnerabilities of cancer cellsCancer cell proliferation in vitroXenografted NOD/SCID miceCell proliferation in vitroClinically approved inhibitorSevere adverse effectsPrevent tumor developmentProliferation in vitroCancer cell growthCancer cell proliferationOncogene-induced replication stressCombination therapyNOD/SCID miceChk2 signalingCheckpoint kinase Chk2Tumor developmentCancer therapyCheckpoint kinase Chk1Replication stressDNA damage responseCancerCell proliferationDNA replicationAdverse effectsSynergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
Coquel F, Ho S, Tsai K, Yang C, Aze A, Devin J, Chang T, Kong-Hap M, Bioteau A, Moreaux J, Maiorano D, Pourquier P, Yang W, Lin Y, Pasero P. Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth. ELife 2025, 13 DOI: 10.7554/elife.104718.2.Peer-Reviewed Original ResearchCancer cellsVulnerabilities of cancer cellsCancer cell proliferation in vitroXenografted NOD/SCID miceCell proliferation in vitroClinically approved inhibitorSevere adverse effectsPrevent tumor developmentProliferation in vitroCancer cell growthCancer cell proliferationOncogene-induced replication stressCombination therapyNOD/SCID miceChk2 signalingCheckpoint kinase Chk2Tumor developmentCancer therapyCheckpoint kinase Chk1Replication stressDNA damage responseCancerCell proliferationDNA replicationAdverse effects
2024
High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension
Shinohara T, Moonen J, Chun Y, Lee-Yow Y, Okamura K, Szafron J, Kaplan J, Cao A, Wang L, Guntur D, Taylor S, Isobe S, Dong M, Yang W, Guo K, Franco B, Pacharinsak C, Pisani L, Saitoh S, Mitani Y, Marsden A, Engreitz J, Körbelin J, Rabinovitch M. High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension. Arteriosclerosis Thrombosis And Vascular Biology 2024, 45: 218-237. PMID: 39723537, PMCID: PMC11753934, DOI: 10.1161/atvbaha.124.321092.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArterial PressureBone Morphogenetic Protein Receptors, Type IICells, CulturedDisease Models, AnimalEndothelial CellsEpithelial-Mesenchymal TransitionHumansHypertension, PulmonaryKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMechanotransduction, CellularMiceMice, Inbred C57BLOncogene ProteinsPulmonary Arterial HypertensionPulmonary ArteryStress, MechanicalTranscriptional Regulator ERGTransfectionVascular RemodelingConceptsPA endothelial cellsPA hypertensionShear stressOcclusive vascular remodelingEndothelial cellsAortocaval shuntVascular remodelingAdeno-associated viral vectorsLaminar shear stressCongenital heart defectsElevated PA pressurePulmonary arterial hypertensionEndothelial-to-mesenchymal transitionHigh shear stressPathologically high shear stressesHistone H3 lysineKruppel-like factorPhysiological laminar shear stressEndothelial-mesenchymal transitionHeart defectsPulmonary arteryArterial hypertensionViral vectorsPA pressureH3 lysineEnhancing the color and stress tolerance of cherry shrimp (Neocaridina davidi var. red) using astaxanthin and Bidens Pilosa
Hou W, Chang Y, Yang W, Gong H, Pan Y, Hsu T, Huang C. Enhancing the color and stress tolerance of cherry shrimp (Neocaridina davidi var. red) using astaxanthin and Bidens Pilosa. PLOS ONE 2024, 19: e0315585. PMID: 39700112, PMCID: PMC11658619, DOI: 10.1371/journal.pone.0315585.Peer-Reviewed Original ResearchConceptsFeeding treatment groupsCherry shrimpColor stabilityBidens pilosaColor difference valuesColor hue angleFeed additive groupsColor expressionStress-related genesEffects of different concentrationsRearing periodHue angleFeed additivesShrimp colourL*Color parametersIncreased rednessStress toleranceAX100Superior color stabilityDecreasing lightTreatment groupsCommercial valueShrimpGene primersHomoplantaginin Antagonizes N‑Methyl‑d‑aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity
Chen T, Chen Y, Hsu M, Liao Y, Wu C, Yao C, Yang W, Lin W, Lin Y. Homoplantaginin Antagonizes N‑Methyl‑d‑aspartate Receptor and Extracellular Signal-Regulated Kinase Signaling in Aβ Oligomers-Induced Neuropathology/Toxicity. Journal Of Agricultural And Food Chemistry 2024, 72: 28294-28304. PMID: 39661093, DOI: 10.1021/acs.jafc.4c07659.Peer-Reviewed Original ResearchConceptsCalcium influxAntagonize N-methyl-D-aspartate receptorsExtracellular signal-regulated kinase signalingAlzheimer's diseaseN-methyl-D-aspartate receptorsImpairment of novel object recognitionNMDA-induced calcium influxMembrane potential sensitive dyeIntracellular calcium measurementsNovel object recognitionKinase signalingAMPA insultClinical therapeutic drugsPotential sensitive dyeERK phosphorylationGlutamatergic neuronsReceptor levelsCalcium measurementsMouse modelSpatial learning/memoryBehavioral testsTherapeutic drugsAnimal behaviorAbnormal depolarizationNatural compoundsCrosstalk Within the Intestinal Epithelium: Aspects of Intestinal Absorption, Homeostasis, and Immunity
Yu L, Yang W, Liang Y. Crosstalk Within the Intestinal Epithelium: Aspects of Intestinal Absorption, Homeostasis, and Immunity. Biomedicines 2024, 12: 2771. PMID: 39767678, PMCID: PMC11673925, DOI: 10.3390/biomedicines12122771.Peer-Reviewed Original ResearchIntestinal epithelial cellsEnteroendocrine cellsIntestinal epithelial stem cellsGut healthPaneth cellsTufted cellsIntestinal functionHealthy gastrointestinal tractNutrient transporter activityActivate Notch signalingEpithelial stem cellsIntestinal cell modelGastrointestinal tractIntestinal absorptionInfluence intestinal functionIntestinal homeostasisRegulation pathwaysGoblet cellsNotch signalingRegulation of intestinal functionCell typesImmune cellsIntestinal epitheliumAgricultural animalsIntestinal immunityTranscriptomics and gut microbiome analysis of the edible herb Bidens pilosa as a functional feed additive to promote growth and metabolism in tilapia (Oreochromis spp.)
Chen C, Lin C, Lu H, Liou C, Ho Y, Huang C, Zhang Z, Kao C, Yang W, Gong H. Transcriptomics and gut microbiome analysis of the edible herb Bidens pilosa as a functional feed additive to promote growth and metabolism in tilapia (Oreochromis spp.). BMC Genomics 2024, 25: 785. PMID: 39138417, PMCID: PMC11323441, DOI: 10.1186/s12864-024-10674-8.Peer-Reviewed Original ResearchConceptsGrowth performanceGut microbiotaB. pilosaAmino acid metabolismGrowth performance of tilapiaSignal transductionGut microbiota of fishMultifunctional feed additiveEnhanced growth performanceExpression of myogenic regulatory factorsPromote muscle growthMicrobiota of fishAmino acidsAcid metabolismComparative transcriptome analysisCarbohydrate metabolismMyogenic regulatory factorsWeeks of feedingComposition of gut bacteriaGut microbiome analysisMuscle growthKEGG enrichment resultsLipid metabolismGrowth-associated genesFunctional enrichment analysisTranscriptomic Insights and the Development of Microsatellite Markers to Assess Genetic Diversity in the Broodstock Management of Litopenaeus stylirostris
Yang Y, Chu P, Chen C, Yang W, Hsu T, Gong H, Liao I, Huang C. Transcriptomic Insights and the Development of Microsatellite Markers to Assess Genetic Diversity in the Broodstock Management of Litopenaeus stylirostris. Animals 2024, 14: 1685. PMID: 38891732, PMCID: PMC11171113, DOI: 10.3390/ani14111685.Peer-Reviewed Original ResearchGenetic diversityMicrosatellite markersTranscriptome databaseDevelopment of microsatellite markersIllumina HiSeq 4000 platformMitigate inbreeding depressionAssessed genetic diversityDisease resistance pathwaysReduced genetic diversityHiSeq 4000 platformModerate genetic variabilityFunctional gene analysisReduce disease susceptibilityDevelopment of markersSignificant inbreedingBlack tiger shrimpFarmed shrimp populationsFunctional annotationInbreeding depressionDinucleotide repeatsTranscriptomic insightsMicrosatellite analysisTranscriptome-basedDiversity analysisGenetic variabilityFunctional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp
Lee Y, Umam K, Kuo T, Yang Y, Feng C, Yang W. Functional and mechanistic studies of a phytogenic formulation, Shrimp Best, in growth performance and vibriosis in whiteleg shrimp. Scientific Reports 2024, 14: 11584. PMID: 38773245, PMCID: PMC11109214, DOI: 10.1038/s41598-024-62436-x.Peer-Reviewed Original ResearchConceptsGrowth performanceWhiteleg shrimpV. parahaemolyticusDecreased feed conversion ratioFeed conversion ratioShrimp body weightInhibited V. parahaemolyticusRegulation of gut microbiotaRRNA sequence dataBacterial membrane destructionShrimp gutConversion ratioShrimp farmingSequence dataL. johnsoniiVibrio parahaemolyticusGut microbiotaVibriosisShrimpPathogenic bacteriaVibrioIn vitro regulationFunctional studiesFatty acidsBody weight
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