Jiang Yu
Postdoctoral AssociateAbout
Research
Publications
2025
Quality evaluation of Semen Platycladi samples of different origins by internal extractive electrospray ionization mass spectrometry
Wang N, Xie S, Liu P, Wang L, Zhong C, Yu J, Qin M, Chen H. Quality evaluation of Semen Platycladi samples of different origins by internal extractive electrospray ionization mass spectrometry. Analytical Methods 2025, 17: 2254-2262. PMID: 39967485, DOI: 10.1039/d4ay01881h.Peer-Reviewed Original ResearchConceptsInternal extractive electrospray ionization mass spectrometryExtractive electrospray ionization mass spectrometryElectrospray ionization mass spectrometryIonization mass spectrometryIEESI-MSMass spectrometryNatural product analysisLimit of quantificationLimit of detectionHigh-throughput analysis platformSemen PlatycladiSample pretreatmentDifferential compoundsDrug discoveryNatural productsProduct analysisPlatycladiSpectrometryAcidStearic acidCompoundsFatty acidsChinese medicineRecovery rateEdgeworthia gardneri (Wall.) Meisn protects against HFD-induced murine atherosclerosis through improving gut microbiota-mediated intestinal barrier integrity
Tang L, Li J, Luan M, Qin M, Zhong C, Zhang Y, Xie Y, Shi M, Qiu L, Yu J. Edgeworthia gardneri (Wall.) Meisn protects against HFD-induced murine atherosclerosis through improving gut microbiota-mediated intestinal barrier integrity. Atherosclerosis 2025, 403: 119132. PMID: 40015156, DOI: 10.1016/j.atherosclerosis.2025.119132.Peer-Reviewed Original ResearchGut barrier integrityGut microbiotaFecal microbiota transplantationLactobacillus plantarumComposition of gut microbiotaHFD-fed ApoE<sup>-/-</sup> miceTransplantation of fecal microbiotaGut microbiota remodelingBarrier integrityHigh-fat dietAbundance of LactobacillusExpression levelsCocktail of antibioticsGut epithelial barrier functionHFD-fed miceAmeliorated lipid accumulationRDNA sequencesThymelaeaceae familyIntestinal barrier integrityGut barrier permeabilityTight junction proteinsMicrobiota remodelingFecal microbiotaEdgeworthia gardneriMicrobiotaIntegrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaque
Zhang Y, Lu S, Qiu L, Qin M, Shan D, Xie L, Yi Y, Yu J. Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaque. Frontiers In Immunology 2025, 15: 1528475. PMID: 39896809, PMCID: PMC11781991, DOI: 10.3389/fimmu.2024.1528475.Peer-Reviewed Original ResearchTranscription factor enrichment analysisTranscription factorsGene OntologyExpressed genesSingle cell RNA-seq dataGene co-expression network analysisCo-expression network analysisGene Expression Omnibus (GEO) databaseRNA-seq analysisGene expression dataCell-cell communication analysisLigand-receptor pairsRNA-seqRegulate ubiquitinationExpression dataMIF signaling pathwaysIntegrated single-cellRNA sequencingEnrichment analysisTarget genesGenesTranscriptionZNF267Signaling pathwayMAPK pathway
2024
Elevated Plasma Soluble (Pro)renin receptor as a potential indicator for heart failure
Xiong J, Yang H, Yi X, Zhou X, Tan W, Song S, Liu C, Wang M, Zhu M, Zheng L, Yu J, Xu C. Elevated Plasma Soluble (Pro)renin receptor as a potential indicator for heart failure. Peptides 2024, 183: 171337. PMID: 39730109, DOI: 10.1016/j.peptides.2024.171337.Peer-Reviewed Original ResearchConceptsHeart failureHF patientsEjection fractionB-type natriuretic peptideSoluble (pro)renin receptorLeft atrial diameterPreserved ejection fractionReduced ejection fractionPlasma renin activityMeta-analysisNon-HF groupAtrial diameterHFpEF patientsNatriuretic peptideRenin activityAngiotensin IIDiagnostic valueKidney diseaseHFpEFPatientsObservational studyUrea nitrogenHF groupIncreasing evidenceCohortSoluble (pro)renin receptor as a novel laboratory biomarker of atherosclerosis.
Liu C, Song S, Yi X, Yang H, Xiong J, Wang M, Tan W, Zhu M, Zheng L, Yu J, Xu C. Soluble (pro)renin receptor as a novel laboratory biomarker of atherosclerosis. Acta Biochimica Et Biophysica Sinica 2024 PMID: 39394818, DOI: 10.3724/abbs.2024150.Peer-Reviewed Original ResearchPrinciple role of the (pro)renin receptor system in cardiovascular and metabolic diseases: An update
Zhu M, Yi X, Song S, Yang H, Yu J, Xu C. Principle role of the (pro)renin receptor system in cardiovascular and metabolic diseases: An update. Cellular Signalling 2024, 124: 111417. PMID: 39321906, DOI: 10.1016/j.cellsig.2024.111417.Peer-Reviewed Original ResearchConceptsPrr systemMetabolic diseasesLocal renin-angiotensin systemRenin-angiotensin systemLiver diseaseTherapeutic strategiesTherapeutic approachesReceptor systemHeart diseaseMetabolic disordersCardiovascular diseaseDiabetic complicationsPathophysiological impactIntracellular partnersClinical settingReview current knowledgeElevated levelsRegulatory mechanismsSignaling pathwayPathophysiological processesDiseaseLipid metabolismSoluble formCurrent knowledgePRRSaponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation
Zhao S, Guo H, Qiu L, Zhong C, Xue J, Qin M, Zhang Y, Xu C, Xie Y, Yu J. Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation. Scientific Reports 2024, 14: 12917. PMID: 38839811, PMCID: PMC11153636, DOI: 10.1038/s41598-024-61209-w.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesMarrow-derived macrophagesFoam cell formationMacrophage foam cell formationLipid-loweringCell formationApolipoprotein E-deficientHigh-fat diet feedingInhibit macrophage foam cell formationClinical management of atherosclerosisAtherosclerosis plaque formationAnti-atherosclerotic effectsAnti-inflammatory propertiesManagement of atherosclerosisClinical managementAttenuate inflammationLPS-induced inflammatory responseAllii Macrostemonis BulbusCD36 expressionTherapeutic strategiesIn vitro experimentsInflammatory responseAnti-coagulationE deficiencyHigh-fatAnemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation
Chu S, Shan D, He L, Yang S, Feng Y, Zhang Y, Yu J. Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation. Frontiers In Immunology 2024, 15: 1412022. PMID: 38881898, PMCID: PMC11176519, DOI: 10.3389/fimmu.2024.1412022.Peer-Reviewed Original ResearchVascular smooth muscle cellsAbdominal aortic aneurysmVascular smooth muscle cell dedifferentiationAbdominal aortic aneurysm formationAortic aneurysmMatrix metalloproteinasesVascular smooth muscle cell transdifferentiationAbdominal aortic aneurysms ManagementExpression of matrix metalloproteinasesIncreased expression of matrix metalloproteinasesSmooth muscle cellsDecreasing vascular inflammationInflammation in vitroModel in vivoAnemoside B4Macrophage-like cellsModel in vitroAAA developmentAbnormal dilatationChronic inflammationAAA pathogenesisVascular inflammationMuscle cellsEffects of anemoside B4MMP expressionDecreased plasma ELABELA level as a novel screening indicator for heart failure: a cohort and observational study
Liu C, Xiong J, Yi X, Song S, Yang H, Tan W, Yang X, Zheng L, Yu J, Xu C. Decreased plasma ELABELA level as a novel screening indicator for heart failure: a cohort and observational study. Scientific Reports 2024, 14: 11333. PMID: 38760403, PMCID: PMC11101417, DOI: 10.1038/s41598-024-61480-x.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionB-type natriuretic peptideElabela levelsPlasma apelin levelsApelin levelsHF patientsHeart failureCardiac functionAssessment of B-type natriuretic peptideDecreased LVEFDiagnostic valueLeft ventricular end-diastolic diameterLeft ventricular end-systolic diameterLeft ventricular posterior wall thicknessVentricular end-diastolic diameterNew York Heart Association gradeObservational studyLeft atrial diameterVentricular ejection fractionEnd-diastolic diameterEnd-systolic diameterPosterior wall thicknessG protein-coupled receptor APJNon-HF patientsReceiver operating characteristic curveEndothelial Mitochondria-Associated Membranes (MAMs) Isolation by Percoll Step Gradients
Baldini M, Zhang C, Yu J. Endothelial Mitochondria-Associated Membranes (MAMs) Isolation by Percoll Step Gradients. Methods In Molecular Biology 2024, 2782: 113-122. PMID: 38622396, DOI: 10.1007/978-1-0716-3754-8_8.Peer-Reviewed Original ResearchConceptsMitochondria-associated membranesEndoplasmic reticulumIntercellular adhesion molecule-1Vascular cell adhesion molecule-1Adhesion molecule-1Toll-like receptorsEndothelial cellsPercoll step gradientMolecule-1Pattern recognition receptorsLipid traffickingER stressCell adhesion molecule-1Innate immune cellsLevels of pattern recognition receptorsStep gradientSubcellular fractionsExpressing adhesion moleculesExpression levels of pattern recognition receptorsRecognition receptorsImmune cellsCalcium signalingExpression levelsEndothelial functionE-selectin
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