Elizabeth Corbett
Research Associate 2-ImmunobiologyCards
About
Research
Publications
2024
Low concordance between QIAreach QuantiFERON-TB, a novel interferon-gamma release assay, and QuantiFERON-TB Gold Plus, in a population-based survey in Blantyre, Malawi
Rickman H, Phiri M, Mbale H, Horton K, Henrion M, Nightingale E, Seddon J, Corbett E, MacPherson P. Low concordance between QIAreach QuantiFERON-TB, a novel interferon-gamma release assay, and QuantiFERON-TB Gold Plus, in a population-based survey in Blantyre, Malawi. Journal Of Clinical Microbiology 2024, 63: e01323-24. PMID: 39699188, PMCID: PMC11784431, DOI: 10.1128/jcm.01323-24.Peer-Reviewed Original ResearchConceptsInterferon-gamma release assayQuantiFERON-TB Gold PlusPopulation-based surveyQFT-PlusQuantiFERON-TBChildren aged 1Gold PlusRelease assayCross-sectional surveyDiagnostic evaluationMtb infectionPopulation-representative sampleSample of children aged 1Young childrenTime to positivityAged 1Primary careLow-income countriesHigh-burden countriesHigh-burden settingsTB goalsHigh-incidence settingsLow-incomeVolume of venous bloodQFT resultsService quality in decentralized community-based Covid-19 antigen rapid diagnostic testing programmes in the Federal Capital Territory, Nigeria
Udoh E, Okonkwo O, Omoregie G, Ura-Akubo V, Anosike N, Folorunsho J, Orakwelu E, Bimba J, Hatzold K, Corbett E, Nightingale E, Dunkley Y. Service quality in decentralized community-based Covid-19 antigen rapid diagnostic testing programmes in the Federal Capital Territory, Nigeria. PLOS ONE 2024, 19: e0310294. PMID: 39656700, PMCID: PMC11630617, DOI: 10.1371/journal.pone.0310294.Peer-Reviewed Original ResearchConceptsPrimary health centersPatent medicine storesPrimary healthcare centersHealth centersCommunity pharmaciesMedicine storesPost-test phaseHealthcare centersCommunity-level servicesQuality improvement initiativesFederal Capital TerritoryLocal implementation contextCommunity healthcare facilitiesRapid diagnostic testsAntigen rapid diagnostic testsImprovement initiativesPre-test phaseHealthcare facilitiesTesting servicesImplementation contextCOVID-19 testingOverall scoreAffluent communitiesPharmacyEvaluation domainsOptimising instructional materials for Covid-19 rapid tests for self-sampling and testing: Mapping the optimization process of manufacturer’s instructions for use for self-testing RDTs intended for low-literacy contexts
Kumwenda M, Mukoka M, Reipold-Ivanova E, Mhango O, Dunkley Y, Abok F, Sibanda E, Watadzaushe C, Corbett E, Choko A. Optimising instructional materials for Covid-19 rapid tests for self-sampling and testing: Mapping the optimization process of manufacturer’s instructions for use for self-testing RDTs intended for low-literacy contexts. PLOS ONE 2024, 19: e0314273. PMID: 39585816, PMCID: PMC11588253, DOI: 10.1371/journal.pone.0314273.Peer-Reviewed Original ResearchConceptsSelf-samplingManufacturer's instructionsRapid Test DeviceHealthcare providersAnterior naresCommunity membersCognitive interviewsPanbio COVID-19 Ag Rapid Test DeviceNasal self-samplingStandard Q COVID-19 Ag testFramework analysis approachSynthesize qualitative dataSARS-CoV-2 self-testingSelf-test kitsSelf-testingLay community membersMiddle-income countriesCOVID-19 rapid testsMiddle-income contextsStructured Interview GuideAg testInterview guideRapid testObservation checklistSD BiosensorImpact of active case finding for tuberculosis with mass chest X-ray screening in Glasgow, Scotland, 1950–1963: An epidemiological analysis of historical data
MacPherson P, Stagg H, Schwalb A, Henderson H, Taylor A, Burke R, Rickman H, Miller C, Houben R, Dodd P, Corbett E. Impact of active case finding for tuberculosis with mass chest X-ray screening in Glasgow, Scotland, 1950–1963: An epidemiological analysis of historical data. PLOS Medicine 2024, 21: e1004448. PMID: 39499677, PMCID: PMC11537369, DOI: 10.1371/journal.pmed.1004448.Peer-Reviewed Original ResearchConceptsCase notification rateActive case findingCase notificationChest X-ray screeningHighest tuberculosis burden countriesInterrupted time series analysisSynthesis of evidenceMultilevel regression modelsPublic health recordsScreening interventionsTuberculosis burden countriesX-ray screeningPost-interventionHealth recordsHigh-burden countriesPre-interventionScreening programmeAnnual rate of declineCase findingContemporaneous interventionsNotification ratesScreening toolBurden countriesBCG vaccination programmeCity wardsSequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study
Olbrich L, Franckling-Smith Z, Larsson L, Sabi I, Ntinginya N, Khosa C, Banze D, Nliwasa M, Corbett E, Semphere R, Verghese V, Michael J, Ninan M, Saathoff E, McHugh T, Razid A, Graham S, Song R, Nabeta P, Trollip A, Nicol M, Hoelscher M, Geldmacher C, Heinrich N, Zar H, consortium R, Dalgarno C, Mtafya B, Mwambola H, Manyama C, Sudi L, Sichone E, Mapamba D, Olomi W, Edwin P, Chacko A, Kumari R, Krishnan D, Munisamy N, Mani D, Maueia C, Madeira C, Kachere D, Chinoko T, Sikwese T, Mnyanga A, Chiume L, Mantsoki A, Baard C, Munro J, Prins M, Benzi N, Bateman L, Ryan A, Booi K, Paulo N, Heydenrych A, Petersen W, Brookes R, Mento M, Centner C. Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study. The Lancet Infectious Diseases 2024, 25: 188-197. PMID: 39312914, DOI: 10.1016/s1473-3099(24)00494-8.Peer-Reviewed Original ResearchMicrobiological confirmationInduced sputumSpontaneous sputumM tuberculosisSecondary analysisMicrobiological resultsGerman Center for Infection ResearchAnti-tuberculosis medicationsXpert MTB/RIF UltraHigh-risk subgroupsDiagnostic accuracy studiesSpecimen typesHealth-care centresUK Medical Research CouncilMiddle-income countriesNasopharyngeal aspiratesExtrapulmonary tuberculosisMedian agePaediatric tuberculosisPositive culturesGastric aspiratesSputumLowenstein-JensenMedical Research CouncilChoice of testsCombined interventions for the testing and treatment of HIV and schistosomiasis among fishermen in Malawi: a three-arm, cluster-randomised trial
Choko A, Dovel K, Kayuni S, Conserve D, Buttterworth A, Bustinduy A, Stothard J, Kamchedzera W, Mukoka-Thindwa M, Jafali J, MacPherson P, Fielding K, Desmond N, Corbett E. Combined interventions for the testing and treatment of HIV and schistosomiasis among fishermen in Malawi: a three-arm, cluster-randomised trial. The Lancet Global Health 2024, 12: e1673-e1683. PMID: 39304239, PMCID: PMC11420466, DOI: 10.1016/s2214-109x(24)00283-3.Peer-Reviewed Original ResearchConceptsVoluntary male medical circumcisionHIV self-test kitsCluster randomised trialSelf-test kitsPeer educatorsDistribution of HIV self-testing kitsIncrease uptake of ARTSOC groupUptake of antiretroviral therapyThree-armEnhanced standard of careAntiretroviral therapyRisk ratioNational Institute for Health ResearchHard-to-reach communitiesMale medical circumcisionUK National Institute for Health ResearchStandard of careProportion of participantsIntracluster correlation coefficientPE groupComputer-generated random numbersActive schistosomiasisUndiagnosed HIVAntiretroviral therapy initiationUtility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting
Randall P, Mutsvangwa J, Nliwasa M, Wilson L, Makamure B, Makambwa E, Meldau R, Dheda K, Munyati S, Siddiqi O, Corbett E, Esmail A. Utility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting. Open Forum Infectious Diseases 2024, 11: ofae496. PMID: 39286031, PMCID: PMC11403475, DOI: 10.1093/ofid/ofae496.Peer-Reviewed Original ResearchUnstimulated interferon-gammaTuberculous meningitisPolymerase chain reaction productsCerebrospinal fluidXpert UltraDNA-based assaysInterferon-gammaHuman immunodeficiency virus (HIV)-infectedSuspected TBM patientsRule-in testPositive predictive valueGeneXpert UltraStage 2 evaluationTBM patientsSame-day testingNon-TBMZambian samplesUninfected participantsDiagnostic performanceAfrican samplesImmunodiagnostic assaysXpertMicrobiological resultsAssayBiobank samplesCosts of HIV testing services in sub-Saharan Africa: a systematic literature review
Ahmed N, Ong J, McGee K, d’Elbée M, Johnson C, Cambiano V, Hatzold K, Corbett E, Terris-Prestholt F, Maheswaran H. Costs of HIV testing services in sub-Saharan Africa: a systematic literature review. BMC Infectious Diseases 2024, 22: 980. PMID: 39192180, PMCID: PMC11348535, DOI: 10.1186/s12879-024-09770-7.Peer-Reviewed Original ResearchConceptsHIV testing servicesHome-basedSub-Saharan AfricaTesting servicesGeneral populationHIV testing modalitiesHIV self-testingSystematic literature reviewSub-SaharanHIV-positive personsResultsSixty-five studiesTesting modalitiesHIV testingHealth facilitiesSelf-testingElectronic databasesLiterature reviewIncremental cost estimatesMale partnersIncremental costPrimary testHIVCost estimatesCampaign-styleServicesCost-effectiveness of COVID rapid diagnostic tests for patients with severe/critical illness in low- and middle-income countries: A modeling study
Bonnet G, Bimba J, Chavula C, Chifamba H, Divala T, Lescano A, Majam M, Mbo D, Suwantika A, Tovar M, Yadav P, Ekwunife O, Mangenah C, Ngwira L, Corbett E, Jit M, Vassall A. Cost-effectiveness of COVID rapid diagnostic tests for patients with severe/critical illness in low- and middle-income countries: A modeling study. PLOS Medicine 2024, 21: e1004429. PMID: 39024370, PMCID: PMC11293649, DOI: 10.1371/journal.pmed.1004429.Peer-Reviewed Original ResearchConceptsEffects of corticosteroidsMiddle-income countriesCOVID-like illnessCountry income levelInfluenza prevalenceSide effectsHigh index of suspicionSide effects of corticosteroidsInterleukin-6 receptor blockerIndex of suspicionImpact of corticosteroidsRapid diagnostic testsSARS-CoV-2Level of suspicionTreatment of patientsTesting of patientsStandard of careNegative test resultsCoronavirus diseaseHealthcare provider perspectiveSevere influenzaCOVID testingLower-middle-income countriesInfluenza outcomesInfluenza casesTuberculosis Immunoreactivity Surveillance in Malawi (Timasamala)—A protocol for a cross-sectional Mycobacterium tuberculosis immunoreactivity survey in Blantyre, Malawi
Rickman H, Phiri M, Feasey H, Mbale H, Nliwasa M, Semphere R, Chagaluka G, Fielding K, Mwandumba H, Horton K, Nightingale E, Henrion M, Mbendera K, Mpunga J, Corbett E, MacPherson P. Tuberculosis Immunoreactivity Surveillance in Malawi (Timasamala)—A protocol for a cross-sectional Mycobacterium tuberculosis immunoreactivity survey in Blantyre, Malawi. PLOS ONE 2024, 19: e0291215. PMID: 38787869, PMCID: PMC11125513, DOI: 10.1371/journal.pone.0291215.Peer-Reviewed Original ResearchConceptsAnnual risk of TB infectionDisease prevalence surveyArea-level risk factorsHIV prevalence citiesPrevalence surveyCase notificationPublic health programmesCross-sectional surveyRisk of TB infectionEpidemiological dataAccurate epidemiological dataHealth programmesTB goalsTargeted interventionsTB infectionTB programmeHigh-risk groupDisease notificationTB surveillanceInterferon-gamma release assayRisk factorsAnnual riskBlantyreMalawiSurvey