2023
Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study
Morton S, Hehnly C, Burgoine K, Ssentongo P, Ericson J, Kumar M, Hagmann C, Fronterre C, Smith J, Movassagh M, Streck N, Bebell L, Bazira J, Kumbakumba E, Bajunirwe F, Mulondo R, Mbabazi-Kabachelor E, Nsubuga B, Natukwatsa D, Nalule E, Magombe J, Erickson T, Ngonzi J, Ochora M, Olupot-Olupot P, Onen J, Ssenyonga P, Mugamba J, Warf B, Kulkarni A, Lane J, Whalen A, Zhang L, Sheldon K, Meier F, Kiwanuka J, Broach J, Paulson J, Schiff S. Paenibacillus spp infection among infants with postinfectious hydrocephalus in Uganda: an observational case-control study. The Lancet Microbe 2023, 4: e601-e611. PMID: 37348522, PMCID: PMC10529524, DOI: 10.1016/s2666-5247(23)00106-4.Peer-Reviewed Original ResearchConceptsMother-newborn pairsPostinfectious hydrocephalusCerebrospinal fluidNeonatal sepsisSpp infectionUgandan infantsMaternal bloodObservational case-control studyHospital OfficeInfant's cerebrospinal fluidBurden of morbidityCase-control studyRoute of infectionSubset of participantsMaternal feverCranial ultrasoundNeonatal infectionSepsis cohortOptimise treatmentTransplacental transmissionCord bloodObservational studyPlacental samplesSepsisHydrocephalusInfection diagnosis in hydrocephalus CT images: a domain enriched attention learning approach
Yu M, Peterson M, Cherukuri V, Hehnly C, Mbabazi-Kabachelor E, Mulondo R, Kaaya B, Broach J, Schiff S, Monga V. Infection diagnosis in hydrocephalus CT images: a domain enriched attention learning approach. Journal Of Neural Engineering 2023, 20: 10.1088/1741-2552/acd9ee. PMID: 37253355, PMCID: PMC11099590, DOI: 10.1088/1741-2552/acd9ee.Peer-Reviewed Original Research
2022
Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus
Hehnly C, Ssentongo P, Bebell L, Burgoine K, Bazira J, Fronterre C, Kumbakumba E, Mulondo R, Mbabazi-Kabachelor E, Morton S, Ngonzi J, Ochora M, Olupot-Olupot P, Mugamba J, Onen J, Roberts D, Sheldon K, Sinnar S, Smith J, Ssenyonga P, Kiwanuka J, Paulson J, Meier F, Ericson J, Broach J, Schiff S. Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus. International Journal Of Infectious Diseases 2022, 118: 24-33. PMID: 35150915, PMCID: PMC9058984, DOI: 10.1016/j.ijid.2022.02.005.Peer-Reviewed Original ResearchConceptsNewborn-mother pairsCMV prevalenceClinical sepsisCytomegalovirus infectionCerebrospinal fluidPrevalence of CMVQuantitative PCRCMV positivityPostinfectious hydrocephalusVaginal sheddingCMV infectionHIV seropositivityNeonatal ageMaternal ageMaternal vaginalRisk factorsMedical CenterLong-term consequencesMother pairsSepsisNeonatesInfantsPrevalenceHydrocephalusCMVImproving Infant Hydrocephalus Outcomes in Uganda: A Longitudinal Prospective Study Protocol for Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure after ETV/CPC
Vadset T, Rajaram A, Hsiao C, Katungi M, Magombe J, Seruwu M, Nsubuga B, Vyas R, Tatz J, Playter K, Nalule E, Natukwatsa D, Wabukoma M, Perez L, Mulondo R, Queally J, Fenster A, Kulkarni A, Schiff S, Grant P, Kabachelor E, Warf B, Sutin J, Lin P. Improving Infant Hydrocephalus Outcomes in Uganda: A Longitudinal Prospective Study Protocol for Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure after ETV/CPC. Metabolites 2022, 12: 78. PMID: 35050201, PMCID: PMC8781620, DOI: 10.3390/metabo12010078.Peer-Reviewed Original ResearchCerebral blood flowTreatment failureETV/CPCEarly treatment failureProspective study protocolCerebral tissue oxygenationProgression of hydrocephalusVentriculoperitoneal shunt placementLong-term outcomesEvidence-based guidelinesPost-operative careEndoscopic third ventriculostomyCerebral metabolic rateMulti-center trialChoroid plexus cauterizationGlobal health burdenCURE Children's HospitalYears of agePost-operative measurementsHydrocephalus outcomesNeurodevelopmental outcomesSurgical treatmentNeurodevelopmental assessmentShunt placementChildren's HospitalProceedings of the 13th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical.
Balashova E, Beaulieu O, Benhmida I, Birca A, Boylan G, Carkeek K, Chowdhury R, Cilio MR, Consoli A, Cote Corriveau G, Cuddyer D, Degtyarev D, Dehaes M, Dempsey E, Dereymaeker A, Desnous B, El-Dib M, Elsayed E, Feldman HA, Finn D, Franceschini MA, Freeman S, Gagnon MM, Gagnon M, Garvey A, Ghosh A, Golubtsova Y, Grant PE, Hay SC, Hermans T, Herzberg E, Hsiao CH, Iennaco M, Inder T, Ionov O, Kaya K, Keister F, Kemigisha M, Kirtbaya A, Lee S, Leijser L, Liao S, Lin PY, Lippman R, Livingstone V, Luu TM, Magombe J, Mahdi Z, Marandyuk B, Martin A, Mathieson S, Mbabazi E, Mohammad K, Moore M, Mulondo R, Munster C, Murray D, Nalule E, Natukwatsa D, Naulaers G, Noroozi M, Nsubuga B, O'Toole J, Pavel A, Peterson M, Pinchefsky E, Playter K, Queally J, Rajaram A, Ryndin A, Schiff S, Seruwu M, Sharafutdinova D, Sheldon Y, Simard MN, Sims J, Steele T, Stritzke A, Sunwoo J, Sutin J, Tatz J, Vadset T, Vesoulis Z, Vyas R, Wabukoma M, Walsh B, Wandukwa J, Warf B, Whitehead H, Woglom M, Yen FY, Zampolli L, Zavriyev AI, Zein H, Zimmermann B, Zubkov V. Proceedings of the 13th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical. J Neonatal Perinatal Med 2022, 15: 453-465. PMID: 35431188, DOI: 10.3233/NPM-229005.Peer-Reviewed Original Research
2021
Vaginal microbiome topic modeling of laboring Ugandan women with and without fever
Movassagh M, Bebell L, Burgoine K, Hehnly C, Zhang L, Moran K, Sheldon K, Sinnar S, Mbabazi-Kabachelor E, Kumbakumba E, Bazira J, Ochora M, Mulondo R, Nsubuga B, Weeks A, Gladstone M, Olupot-Olupot P, Ngonzi J, Roberts D, Meier F, Irizarry R, Broach J, Schiff S, Paulson J. Vaginal microbiome topic modeling of laboring Ugandan women with and without fever. Npj Biofilms And Microbiomes 2021, 7: 75. PMID: 34508087, PMCID: PMC8433417, DOI: 10.1038/s41522-021-00244-1.Peer-Reviewed Original ResearchConceptsIntrapartum feverClinical variablesHigh prevalenceVaginal microbiomeUgandan womenLonger labour durationMaternal clinical featuresYoung maternal ageDuration of pregnancyOnset of laborMicrobial communitiesVaginal microbial communitiesAfebrile mothersFebrile mothersPeripartum courseMaternal feverNeonatal outcomesLabor durationClinical featuresMaternal ageVaginal microbesFeverOutcome riskVeillonella genusMicrobiome influencesImmune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection
Isaacs A, Morton S, Movassagh M, Zhang Q, Hehnly C, Zhang L, Morales D, Sinnar S, Ericson J, Mbabazi-Kabachelor E, Ssenyonga P, Onen J, Mulondo R, Hornig M, Warf B, Broach J, Townsend R, Limbrick D, Paulson J, Schiff S. Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection. IScience 2021, 24: 102351. PMID: 33912816, PMCID: PMC8065213, DOI: 10.1016/j.isci.2021.102351.Peer-Reviewed Original ResearchNeonatal sepsisBrain infectionImmune activationInnate immune system responseRisk of hydrocephalusDominant bacterial pathogenHost immune responsePlatelet-activating factorImmune system responseOxidative stress reactionSecondary sequelaeAdjunctive treatmentImmune response networkNeutrophil activityIL-12Hydrocephalic infantsAfrican infantsIL-13IL-4JAK/STAT pathwayAntigen-presenting complexImmune responseHydrocephalusPotential targetNeuroinflammation
2020
Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants
Paulson J, Williams B, Hehnly C, Mishra N, Sinnar S, Zhang L, Ssentongo P, Mbabazi-Kabachelor E, Wijetunge D, von Bredow B, Mulondo R, Kiwanuka J, Bajunirwe F, Bazira J, Bebell L, Burgoine K, Couto-Rodriguez M, Ericson J, Erickson T, Ferrari M, Gladstone M, Guo C, Haran M, Hornig M, Isaacs A, Kaaya B, Kangere S, Kulkarni A, Kumbakumba E, Li X, Limbrick D, Magombe J, Morton S, Mugamba J, Ng J, Olupot-Olupot P, Onen J, Peterson M, Roy F, Sheldon K, Townsend R, Weeks A, Whalen A, Quackenbush J, Ssenyonga P, Galperin M, Almeida M, Atkins H, Warf B, Lipkin W, Broach J, Schiff S. Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants. Science Translational Medicine 2020, 12 PMID: 32998967, PMCID: PMC7774825, DOI: 10.1126/scitranslmed.aba0565.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusCSF samplesPIH casesPotential causative organismsCerebrospinal fluid accumulationCytomegalovirus coinfectionUgandan infantsNeonatal sepsisSurgical palliationNeonatal infectionInfant casesOptimal treatmentInfant cohortCommon causeCausative organismPediatric hydrocephalusFluid accumulationHydrocephalusAnaerobic bacterial isolatesControl casesInfectionFacultative anaerobic bacterial isolatesInfantsParasitic DNADisease
2009
Neurocognitive outcome and ventricular volume in children with myelomeningocele treated for hydrocephalus in Uganda.
Warf B, Ondoma S, Kulkarni A, Donnelly R, Ampeire M, Akona J, Kabachelor CR, Mulondo R, Nsubuga BK. Neurocognitive outcome and ventricular volume in children with myelomeningocele treated for hydrocephalus in Uganda. J Neurosurg Pediatr 2009, 4: 564-70. PMID: 19951045, DOI: 10.3171/2009.7.PEDS09136.Peer-Reviewed Original Research