2024
Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG)
Kostka J, Maharjan A, Kumar S, Hackenyos D, Krause P, Dieckhaus K. Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). PLOS Neglected Tropical Diseases 2024, 18: e0012035. PMID: 38484010, PMCID: PMC10965045, DOI: 10.1371/journal.pntd.0012035.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ProtozoanBabesia microtiBabesiosisEnzyme-Linked Immunosorbent AssayHumansImmunoglobulins, IntravenousConceptsIntravenous immunoglobulinB. microti antibodiesBabesiosis patientsSpectrum of disease severityCommercial intravenous immunoglobulinEffective treatment strategiesSevere organ damageHost antibody responseImmunocompromised patientsAdjunctive therapyOrgan damageTreatment strategiesAcute andClinical trialsMicroti antibodiesAsymptomatic infectionAntibody responseTherapeutic benefitTherapeutic effectPatientsDisease severityAntibodiesImmunofluorescence assayProtozoan infectionsCommercial samples
2020
Antigen Discovery, Bioinformatics and Biological Characterization of Novel Immunodominant Babesia microti Antigens
Verma N, Puri A, Essuman E, Skelton R, Anantharaman V, Zheng H, White S, Gunalan K, Takeda K, Bajpai S, Lepore TJ, Krause PJ, Aravind L, Kumar S. Antigen Discovery, Bioinformatics and Biological Characterization of Novel Immunodominant Babesia microti Antigens. Scientific Reports 2020, 10: 9598. PMID: 32533024, PMCID: PMC7293334, DOI: 10.1038/s41598-020-66273-6.Peer-Reviewed Original ResearchConceptsPotential biological functionsBiological functionsCellular localization studiesB. microtiEvolutionary relationshipsDomain architectureBioinformatics analysisRecombinant proteinsExtracellular domainLocalization studiesPrimary causative agentUnrelated groupsE. coliBiological characterizationNovel assayIntraerythrocytic parasitesBabesia microtiDistinct classesProteinCausative agentAntigen discoveryGlobal public health impactB. microti antibodiesB. microti antigenTransfusion of blood
2003
Increasing health burden of human babesiosis in endemic sites.
KRAUSE PJ, McKay K, Gadbaw J, Christianson D, Closter L, Lepore T, TELFORD SR, Sikand V, Ryan R, Persing D, RADOLF JD, Spielman A, _ _. Increasing health burden of human babesiosis in endemic sites. American Journal Of Tropical Medicine And Hygiene 2003, 68: 431-6. PMID: 12875292, DOI: 10.4269/ajtmh.2003.68.431.Peer-Reviewed Original ResearchConceptsYears of ageEndemic sitesCommunity-based serosurveysClinical spectrumHealth burdenPeople 20Borrelial infectionHuman infectionsBabesial infectionMore older adultsBabesia microtiBabesial antigensOlder adultsHuman babesiosisYoung adultsInfectionBorrelia burgdorferiIncidenceThree-fourthsAdultsAgePrudence IslandSeroprevalenceSerosurveyHospital
2001
Diagnosis of Babesiosis Using an Immunoblot Serologic Test
Ryan R, Krause P, Radolf J, Freeman K, Spielman A, Lenz R, Levin A. Diagnosis of Babesiosis Using an Immunoblot Serologic Test. MSphere 2001, 8: 1177-1180. PMID: 11687460, PMCID: PMC96246, DOI: 10.1128/cdli.8.6.1177-1180.2001.Peer-Reviewed Original ResearchConceptsB. microti antigenAntibody testHuman babesiosisB. microtiReactivity of seraDiagnostic antibody testsHuman granulocytic ehrlichiosisDiagnosis of babesiosisImmunoblot stripsRoutine clinical diagnosisSerologic testsAcute babesiosisIFA testLaboratory evidenceClinical diagnosisImmunoblot assayGranulocytic ehrlichiosisLyme diseaseAntigenSerumGI strainsInterpretive criteriaReactive bandsTest sensitivityHuman subjects
1995
Infection with a Babesia-Like Organism in Northern California
Persing D, Herwaldt B, Glaser C, Lane R, Thomford J, Mathiesen D, Krause P, Phillip D, Conrad P. Infection with a Babesia-Like Organism in Northern California. New England Journal Of Medicine 1995, 332: 298-303. PMID: 7816065, DOI: 10.1056/nejm199502023320504.Peer-Reviewed Original ResearchConceptsB. microti antigenIndirect immunofluorescent antibody testingImmunofluorescent antibody testingInfluenza-like illnessHodgkin's diseaseSerologic testingAsymptomatic infectionClinical spectrumSeroprevalence ratesPolymerase chain reactionPatientsFatal diseaseProtozoal parasitesInfectionBabesia microtiHuman babesiosisBabesia antigensDiseaseGenetic sequence analysisChain reactionCanine pathogensAntigenB. divergensGenus Babesia