2023
Transfusion-transmitted Babesia spp.: a changing landscape of epidemiology, regulation, and risk mitigation
Drews S, Kjemtrup A, Krause P, Lambert G, Leiby D, Lewin A, O'Brien S, Renaud C, Tonnetti L, Bloch E. Transfusion-transmitted Babesia spp.: a changing landscape of epidemiology, regulation, and risk mitigation. Journal Of Clinical Microbiology 2023, 61: e01268-22. PMID: 37750699, PMCID: PMC10595070, DOI: 10.1128/jcm.01268-22.Peer-Reviewed Original ResearchConceptsBlood productsWhole blood-derived platelet concentratesNon-endemic areasNon-endemic regionsTTB casesMost patientsRed blood cellsClinical presentationSevere illnessBlood donorsDead-end hostsTick-borne parasitesHuman transmissionEndemic regionsClinical settingEpidemiologyBlood cellsCase numbersPlatelet concentratesTransfusionRiskThe impact of ABO and RhD blood types on Babesia microti infection
Jajosky R, O’Bryan J, Spichler-Moffarah A, Jajosky P, Krause P, Tonnetti L. The impact of ABO and RhD blood types on Babesia microti infection. PLOS Neglected Tropical Diseases 2023, 17: e0011060. PMID: 36696414, PMCID: PMC9901808, DOI: 10.1371/journal.pntd.0011060.Peer-Reviewed Original ResearchConceptsB. microti infectionABO blood typeBabesia microti infectionMicroti infectionBlood donorsBlood typeDisease severityPlasmodium falciparum malaria patientsFalciparum malaria patientsHigher peak parasitemiaRed blood cell antigensType BImpact of ABOBlood cell antigensBlood type BMalaria patientsTransfusion strategyInfected donorsRhD blood typeSevere diseasePeak parasitemiaB antigensCell antigensPossible associationRhD antigen
2020
Borrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors
Brummitt SI, Kjemtrup AM, Harvey DJ, Petersen JM, Sexton C, Replogle A, Packham AE, Bloch EM, Barbour AG, Krause PJ, Green V, Smith WA. Borrelia burgdorferi and Borrelia miyamotoi seroprevalence in California blood donors. PLOS ONE 2020, 15: e0243950. PMID: 33370341, PMCID: PMC7769429, DOI: 10.1371/journal.pone.0243950.Peer-Reviewed Original ResearchConceptsLyme diseaseBlood donorsB. miyamotoiB. burgdorferiEndemic countiesWestern blotBorrelia miyamotoiB. burgdorferi antibodiesAdult blood donorsBorrelia burgdorferiIgG Western blotBlood donor seraRisk of infectionELISA test systemBurgdorferi antibodiesDonor seraC6 ELISAClinical casesEquivocal samplesHuman casesDiseaseAntibodiesI. pacificus ticksMiyamotoiBurgdorferi
2018
Superior real‐time polymerase chain reaction detection of Babesia microti parasites in whole blood utilizing high‐copy BMN antigens as amplification targets
Grabias B, Clement J, Krause PJ, Lepore T, Kumar S. Superior real‐time polymerase chain reaction detection of Babesia microti parasites in whole blood utilizing high‐copy BMN antigens as amplification targets. Transfusion 2018, 58: 1924-1932. PMID: 29664114, DOI: 10.1111/trf.14642.Peer-Reviewed Original ResearchMeSH KeywordsAntigensBabesia microtiBlood DonorsHumansReal-Time Polymerase Chain ReactionTransfusion ReactionConceptsParasites/mLBlood donorsBlood samplesSeroreactive antigensBabesia microti parasitesWhole bloodTransfusion-transmitted infectionsParasite nucleic acidsReal-time polymerase chain reactionWhole blood samplesPolymerase chain reaction detectionPolymerase chain reactionSensitive molecular assaysBlood productsClinical characterizationRT-PCR detectionReal-time polymerase chain reaction detectionLaboratory diagnosisBabesia microtiStudy designInfected ticksDilution panelsAntigenZoonotic diseaseBlood
2016
Transfusion-transmitted babesiosis
Levin AE, Krause PJ. Transfusion-transmitted babesiosis. Current Opinion In Hematology 2016, 23: 573-580. PMID: 27537475, PMCID: PMC5241272, DOI: 10.1097/moh.0000000000000287.Peer-Reviewed Original ResearchConceptsTransfusion-transmitted babesiosisBlood donorsB. microti antibodiesInfectious blood donorsAssociated mortality rateOptimal screening strategyTransfusion-transmitted pathogensSignificant health burdenAvailable screening toolsUnited States populationPathogen inactivation methodsMicroti antibodiesSevere illnessHealth burdenMortality rateUS FoodDrug AdministrationBabesia microtiScreening toolLaboratory screeningScreening strategyBabesiosisInactivation methodPCR assaysRecent studies
2012
Preventing transfusion‐transmitted babesiosis: preliminary experience of the first laboratory‐based blood donor screening program
Young C, Chawla A, Berardi V, Padbury J, Skowron G, Krause PJ, Group T. Preventing transfusion‐transmitted babesiosis: preliminary experience of the first laboratory‐based blood donor screening program. Transfusion 2012, 52: 1523-1529. PMID: 22452654, DOI: 10.1111/j.1537-2995.2012.03612.x.Peer-Reviewed Original ResearchConceptsTransfusion-transmitted babesiosisCases of TTBPolymerase chain reactionBlood donorsThalassemia patientsCommon transfusion-transmitted infectionSickle cellsIndeterminate PCR resultsPositive IFA resultsTransfusion-transmitted infectionsInvestigational new drug applicationReal-time polymerase chain reactionUnscreened bloodDonor screeningPatientsIFA resultsDrug AdministrationNew drug applicationsPreliminary experienceIndirect immunofluorescenceBabesia microtiStudy designDrug applicationChain reactionPCR results
1992
Cytomegalovirus antibody detection in blood donors and mothers of very low birth weight neonates by using three serologic methods
Eisenfeld L, McLaughlin J, Mayo D, Klevjer-Anderson P, Silver H, Krause P, Anderson J, Herson V, Savidakis J, Lazar A, Rosenkrantz T, DeSilva H, Ryan R, group C, LeConche D, Donovan T, Ellis K, Buchanan D, Raye J, Pisciotto P, Rowe D, Knox I, Philipps A, Whiteley D, Apollonio J, Schick J, Conlon M. Cytomegalovirus antibody detection in blood donors and mothers of very low birth weight neonates by using three serologic methods. Diagnostic Microbiology And Infectious Disease 1992, 15: 125-128. PMID: 1315230, DOI: 10.1016/0732-8893(92)90035-r.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, ViralBlood DonorsCytomegalovirusCytomegalovirus InfectionsEnzyme-Linked Immunosorbent AssayFemaleFluorescent Antibody TechniqueHumansInfant, Low Birth WeightInfant, NewbornLatex Fixation TestsMaternal-Fetal ExchangePregnancyPregnancy Complications, InfectiousSensitivity and SpecificityConceptsEnzyme-linked immunosorbent assayLow birth weight neonatesBirth weight neonatesBlood donorsLatex agglutinationWeight neonatesAntibody detectionSerologic methodsCMV seroprevalence ratesHealthy blood donorsCMV screeningCMV serologyPremature infantsSeroprevalence ratesAntibody seroprevalenceImmunofluorescent antibodyIFA assayBlood populationsBorderline valuesImmunosorbent assayMaternal populationMothersNeonatesSerumDonors